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The effect of sodium thiopental as a GABA mimetic drug in neonatal period on expression of GAD65 and GAD67 genes in hippocampus of newborn and adult male rats.

Iranian journal of basic medical sciences

Naseri M, Parham A, Moghimi A.
PMID: 29085593
Iran J Basic Med Sci. 2017 Sep;20(9):996-1001. doi: 10.22038/IJBMS.2017.9264.

OBJECTIVES: Development of the nervous system in human and most animals is continued after the birth. Critical role of this period in generation and specialization of the neuronal circuits is confirmed in numerous studies. Any pharmacological intervention in this...

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Naseri M, Parham A, Moghimi A. The effect of sodium thiopental as a GABA mimetic drug in neonatal period on expression of GAD65 and GAD67 genes in hippocampus of newborn and adult male rats. Iran J Basic Med Sci. 2017;20(9):996-1001doi: 10.22038/IJBMS.2017.9264.
Naseri, M., Parham, A., & Moghimi, A. (2017). The effect of sodium thiopental as a GABA mimetic drug in neonatal period on expression of GAD65 and GAD67 genes in hippocampus of newborn and adult male rats. Iranian journal of basic medical sciences, 20(9), 996-1001. https://doi.org/10.22038/IJBMS.2017.9264
Naseri, Masoud, et al. "The effect of sodium thiopental as a GABA mimetic drug in neonatal period on expression of GAD65 and GAD67 genes in hippocampus of newborn and adult male rats." Iranian journal of basic medical sciences vol. 20,9 (2017): 996-1001. doi: https://doi.org/10.22038/IJBMS.2017.9264
Naseri M, Parham A, Moghimi A. The effect of sodium thiopental as a GABA mimetic drug in neonatal period on expression of GAD65 and GAD67 genes in hippocampus of newborn and adult male rats. Iran J Basic Med Sci. 2017 Sep;20(9):996-1001. doi: 10.22038/IJBMS.2017.9264. PMID: 29085593; PMCID: PMC5651466.
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Association of the -243A>G, +61450C>A Polymorphisms of the Glutamate Decarboxylase 2 (GAD2) Gene with Obesity and Insulin Level in North Indian Population.

Iranian journal of public health

Prakash J, Mittal B, Awasthi S, Srivastava N.
PMID: 27252915
Iran J Public Health. 2016 Apr;45(4):460-8.

BACKGROUND: Obesity associated with type 2 diabetes, and hypertension increased mortality and morbidity. Glutamate decarboxylase 2 (GAD2) gene is associated with obesity and it regulate food intake and insulin level. We investigated the association of GAD-2gene -243A>G (rs2236418) and...

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Prakash J, Mittal B, Awasthi S, et al. Association of the -243A>G, +61450C>A Polymorphisms of the Glutamate Decarboxylase 2 (GAD2) Gene with Obesity and Insulin Level in North Indian Population. Iran J Public Health. 2016;45(4):460-8
Prakash, J., Mittal, B., Awasthi, S., & Srivastava, N. (2016). Association of the -243A>G, +61450C>A Polymorphisms of the Glutamate Decarboxylase 2 (GAD2) Gene with Obesity and Insulin Level in North Indian Population. Iranian journal of public health, 45(4), 460-8.
Prakash, Jai, et al. "Association of the -243A>G, +61450C>A Polymorphisms of the Glutamate Decarboxylase 2 (GAD2) Gene with Obesity and Insulin Level in North Indian Population." Iranian journal of public health vol. 45,4 (2016): 460-8.
Prakash J, Mittal B, Awasthi S, Srivastava N. Association of the -243A>G, +61450C>A Polymorphisms of the Glutamate Decarboxylase 2 (GAD2) Gene with Obesity and Insulin Level in North Indian Population. Iran J Public Health. 2016 Apr;45(4):460-8. PMID: 27252915; PMCID: PMC4888173.
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Persistent proteomic changes in glutamatergic and GABAergic signaling in the amygdala of adolescent rats exposed to chlorpyrifos as juveniles.

Neurotoxicology

Alugubelly N, Mohammed AN, Carr RL.
PMID: 34058248
Neurotoxicology. 2021 Jul;85:234-244. doi: 10.1016/j.neuro.2021.05.012. Epub 2021 May 28.

Chlorpyrifos (CPF) remains one of the most widely used organophosphorus insecticides (OPs) despite the concerns about its developmental neurotoxicity. Developmental exposure to CPF has long-lasting negative impacts, including abnormal emotional behaviors. These negative impacts are observed at exposure levels...

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Alugubelly N, Mohammed AN, Carr RL. Persistent proteomic changes in glutamatergic and GABAergic signaling in the amygdala of adolescent rats exposed to chlorpyrifos as juveniles. Neurotoxicology. 2021;85:234-244doi: 10.1016/j.neuro.2021.05.012.
Alugubelly, N., Mohammed, A. N., & Carr, R. L. (2021). Persistent proteomic changes in glutamatergic and GABAergic signaling in the amygdala of adolescent rats exposed to chlorpyrifos as juveniles. Neurotoxicology, 85234-244. https://doi.org/10.1016/j.neuro.2021.05.012
Alugubelly, Navatha, et al. "Persistent proteomic changes in glutamatergic and GABAergic signaling in the amygdala of adolescent rats exposed to chlorpyrifos as juveniles." Neurotoxicology vol. 85 (2021): 234-244. doi: https://doi.org/10.1016/j.neuro.2021.05.012
Alugubelly N, Mohammed AN, Carr RL. Persistent proteomic changes in glutamatergic and GABAergic signaling in the amygdala of adolescent rats exposed to chlorpyrifos as juveniles. Neurotoxicology. 2021 Jul;85:234-244. doi: 10.1016/j.neuro.2021.05.012. Epub 2021 May 28. PMID: 34058248; PMCID: PMC8276847.
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GAD67-mediated GABA Synthesis and Signaling Impinges on Directing Basket Cell Axonal Projections Toward Purkinje Cells in the Cerebellum.

Cerebellum (London, England)

Miwa H, Kobayashi K, Hirai S, Yamada M, Watanabe M, Okado H, Yanagawa Y.
PMID: 34676525
Cerebellum. 2021 Oct 21; doi: 10.1007/s12311-021-01334-8. Epub 2021 Oct 21.

Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the central nervous system, synthesized by two isoforms of glutamate decarboxylase (GAD): GAD65 and GAD67. GABA may act as a trophic factor during brain development, but its contribution to the...

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Miwa H, Kobayashi K, Hirai S, et al. GAD67-mediated GABA Synthesis and Signaling Impinges on Directing Basket Cell Axonal Projections Toward Purkinje Cells in the Cerebellum. Cerebellum. 2021;doi: 10.1007/s12311-021-01334-8.
Miwa, H., Kobayashi, K., Hirai, S., Yamada, M., Watanabe, M., Okado, H., & Yanagawa, Y. (2021). GAD67-mediated GABA Synthesis and Signaling Impinges on Directing Basket Cell Axonal Projections Toward Purkinje Cells in the Cerebellum. Cerebellum (London, England), . https://doi.org/10.1007/s12311-021-01334-8
Miwa, Hideki, et al. "GAD67-mediated GABA Synthesis and Signaling Impinges on Directing Basket Cell Axonal Projections Toward Purkinje Cells in the Cerebellum." Cerebellum (London, England) vol. (2021). doi: https://doi.org/10.1007/s12311-021-01334-8
Miwa H, Kobayashi K, Hirai S, Yamada M, Watanabe M, Okado H, Yanagawa Y. GAD67-mediated GABA Synthesis and Signaling Impinges on Directing Basket Cell Axonal Projections Toward Purkinje Cells in the Cerebellum. Cerebellum. 2021 Oct 21; doi: 10.1007/s12311-021-01334-8. Epub 2021 Oct 21. PMID: 34676525.
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