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Showing 1 to 7 of 7 entries
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Simvastatin Solid Lipid Nanoparticles for Oral Delivery: Formulation Development and In vivo Evaluation.

Indian journal of pharmaceutical sciences

Padhye SG, Nagarsenker MS.
PMID: 24403661
Indian J Pharm Sci. 2013 Sep;75(5):591-8.

Solid lipid nanoparticles have been increasingly utilised for improving oral bioavailability of drugs. Simvastatin is biopharmaceutical class 2 drug with poor oral bioavailability of 5%. In the present study, simvastatin solid lipid nanoparticles were successfully prepared by hot melt...

In vitro controlled release of colon targeted mesalamine from compritol ATO 888 based matrix tablets using factorial design.

Research in pharmaceutical sciences

Patel JK, Patel NV, Shah SH.
PMID: 21589801
Res Pharm Sci. 2009 Jul;4(2):63-75.

A controlled release matrix formulation for mesalamine was designed and developed to achieve a 24 h release profile. Using compritol 888 ATO (glyceryl behenate) as an inert matrix-forming agent to control the release of mesalamine, formulation granules containing the...

The effect of alcohol on ionizing and non-ionizing drug release from hydrophilic, lipophilic and dual matrix tablets.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Lochař V, Komersová A, Matzick K, Slezáková B, Bartoš M, Mužíková J, Haddouchi S.
PMID: 32042257
Saudi Pharm J. 2020 Feb;28(2):187-195. doi: 10.1016/j.jsps.2019.11.020. Epub 2019 Dec 07.

The aim of this work was to investigate and quantitatively evaluate the effect of presence of alcohol on

Multilayer-Coated Tablet of Clopidogrel and Rosuvastatin: Preparation and In Vitro/In vivo Characterization.

Pharmaceutics

Seo KS, Han HK.
PMID: 31277408
Pharmaceutics. 2019 Jul 04;11(7). doi: 10.3390/pharmaceutics11070313.

The acid lability of rosuvastatin hinders the preparation of mixed combination formulations of rosuvastatin with acidic drugs such as clopidogrel. Therefore, the purpose of this study was to develop a multilayer-coated tablet that avoids physicochemical interactions between rosuvastatin and...

Oral Bioavailability Enhancement of Raloxifene with Nanostructured Lipid Carriers.

Nanomaterials (Basel, Switzerland)

Murthy A, Ravi PR, Kathuria H, Malekar S.
PMID: 32486508
Nanomaterials (Basel). 2020 May 31;10(6). doi: 10.3390/nano10061085.

Raloxifene hydrochloride (RLX) shows poor bioavailability (90%). The objective of this study was to develop nanostructured lipid carriers (NLCs) for RLX to enhance its bioavailability. The NLC formulations were produced with glyceryl tribehenate and oleic acid. The particle characteristics,...

Phase Behavior of Drug-Lipid-Surfactant Ternary Systems toward Understanding the Annealing-Induced Change.

Molecular pharmaceutics

Kushwah V, Gomes Lopes D, Saraf I, Koutsamanis I, Werner B, Zangger K, Roy MC, Bartlett JA, Frericks Schmidt H, Shamblin SL, Laggner P, Paudel A.
PMID: 34958588
Mol Pharm. 2021 Dec 27; doi: 10.1021/acs.molpharmaceut.1c00651. Epub 2021 Dec 27.

The present study systematically investigates the effect of annealing conditions and the Kolliphor P 407 content on the physicochemical and structural properties of Compritol (glyceryl behenate) and ternary systems prepared via melt cooling (Kolliphor P 407, Compritol, and a...

Formulation Development, Process Optimization, and In Vitro Characterization of Spray-Dried Lansoprazole Enteric Microparticles.

Scientia pharmaceutica

Vora C, Patadia R, Mittal K, Mashru R.
PMID: 27222612
Sci Pharm. 2016 Apr-Jun;84(2):393-408. doi: 10.3797/scipharm.1501-08. Epub 2015 Jul 29.

This research focuses on the development of enteric microparticles of lansoprazole in a single step by employing the spray drying technique and studies the effects of variegated formulation/process variables on entrapment efficiency and in vitro gastric resistance. Preliminary trials...

Showing 1 to 7 of 7 entries