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Showing 1 to 12 of 73 entries
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Serum glutathione transferase does not respond to indole-3-carbinol: A pilot study.

Therapeutics and clinical risk management

McGrath DR, Frydoonfar H, Hunt JJ, Dunkley CJ, Spigelman AD.
PMID: 20526440
Ther Clin Risk Manag. 2010 May 25;6:225-31. doi: 10.2147/tcrm.s9568.

BACKGROUND: Despite the well recognized protective effect of cruciferous vegetables against various cancers, including human colorectal cancers, little is known about how this effect is conferred. It is thought that some phytochemicals found only in these vegetables confer the...

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McGrath DR, Frydoonfar H, Hunt JJ, et al. Serum glutathione transferase does not respond to indole-3-carbinol: A pilot study. Ther Clin Risk Manag. 2010;6:225-31doi: 10.2147/tcrm.s9568.
McGrath, D. R., Frydoonfar, H., Hunt, J. J., Dunkley, C. J., & Spigelman, A. D. (2010). Serum glutathione transferase does not respond to indole-3-carbinol: A pilot study. Therapeutics and clinical risk management, 6225-31. https://doi.org/10.2147/tcrm.s9568
McGrath, Daniel R, et al. "Serum glutathione transferase does not respond to indole-3-carbinol: A pilot study." Therapeutics and clinical risk management vol. 6 (2010): 225-31. doi: https://doi.org/10.2147/tcrm.s9568
McGrath DR, Frydoonfar H, Hunt JJ, Dunkley CJ, Spigelman AD. Serum glutathione transferase does not respond to indole-3-carbinol: A pilot study. Ther Clin Risk Manag. 2010 May 25;6:225-31. doi: 10.2147/tcrm.s9568. PMID: 20526440; PMCID: PMC2878956.
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Detoxification of isothiocyanate allelochemicals by glutathione transferase in three lepidopterous species.

Journal of chemical ecology

Wadleigh RW, Yu SJ.
PMID: 24276210
J Chem Ecol. 1988 Apr;14(4):1279-88. doi: 10.1007/BF01019352.

Glutathione transferase activity towards various plant isothiocyanates was studied in larvae of the two generalists, fall armyworm [Spodoptera frugiperda (J.E. Smith)], and cabbage looper [Trichoplusia ni (Hübner)], and the specialist, velvetbean caterpillar (Anticarsia gemmatalis Hübner) using the midgut soluble...

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Wadleigh RW, Yu SJ. Detoxification of isothiocyanate allelochemicals by glutathione transferase in three lepidopterous species. J Chem Ecol. 1988;14(4):1279-88doi: 10.1007/BF01019352.
Wadleigh, R. W., & Yu, S. J. (1988). Detoxification of isothiocyanate allelochemicals by glutathione transferase in three lepidopterous species. Journal of chemical ecology, 14(4), 1279-88. https://doi.org/10.1007/BF01019352
Wadleigh, R W, and Yu, S J. "Detoxification of isothiocyanate allelochemicals by glutathione transferase in three lepidopterous species." Journal of chemical ecology vol. 14,4 (1988): 1279-88. doi: https://doi.org/10.1007/BF01019352
Wadleigh RW, Yu SJ. Detoxification of isothiocyanate allelochemicals by glutathione transferase in three lepidopterous species. J Chem Ecol. 1988 Apr;14(4):1279-88. doi: 10.1007/BF01019352. PMID: 24276210.
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A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer.

American journal of translational research

Heath EI, Heilbrun LK, Li J, Vaishampayan U, Harper F, Pemberton P, Sarkar FH.
PMID: 20733950
Am J Transl Res. 2010 Jul 23;2(4):402-11.

UNLABELLED: 3, 3'-diindolylmethane (DIM) modulates estrogen metabolism and acts as an anti-androgen which down-regulates the androgen receptor and prostate specific antigen (PSA). We conducted a dose-escalation, phase I study of BioResponse (BR)-DIM with objectives to determine the maximum tolerated...

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Heath EI, Heilbrun LK, Li J, et al. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am J Transl Res. 2010;2(4):402-11
Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., & Sarkar, F. H. (2010). A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. American journal of translational research, 2(4), 402-11.
Heath, Elisabeth I, et al. "A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer." American journal of translational research vol. 2,4 (2010): 402-11.
Heath EI, Heilbrun LK, Li J, Vaishampayan U, Harper F, Pemberton P, Sarkar FH. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am J Transl Res. 2010 Jul 23;2(4):402-11. PMID: 20733950; PMCID: PMC2923864.
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Hydroxyl Radical Scavenging of Indole-3-Carbinol: A Mechanistic and Kinetic Study.

ACS omega

Vo QV, Van Bay M, Nam PC, Mechler A.
PMID: 31763562
ACS Omega. 2019 Nov 08;4(21):19375-19381. doi: 10.1021/acsomega.9b02782. eCollection 2019 Nov 19.

Indole-3-carbinol (I3C) is the product of the enzymatic hydrolysis of glucobrassicin in the human body. I3C exhibits diverse bioactivities. It is used as a supplement to enhance the efficiency of some cancer therapies and is available as an over-the-counter...

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Vo QV, Van Bay M, Nam PC, et al. Hydroxyl Radical Scavenging of Indole-3-Carbinol: A Mechanistic and Kinetic Study. ACS Omega. 2019;4(21):19375-19381doi: 10.1021/acsomega.9b02782.
Vo, Q. V., Van Bay, M., Nam, P. C., & Mechler, A. (2019). Hydroxyl Radical Scavenging of Indole-3-Carbinol: A Mechanistic and Kinetic Study. ACS omega, 4(21), 19375-19381. https://doi.org/10.1021/acsomega.9b02782
Vo, Quan V, et al. "Hydroxyl Radical Scavenging of Indole-3-Carbinol: A Mechanistic and Kinetic Study." ACS omega vol. 4,21 (2019): 19375-19381. doi: https://doi.org/10.1021/acsomega.9b02782
Vo QV, Van Bay M, Nam PC, Mechler A. Hydroxyl Radical Scavenging of Indole-3-Carbinol: A Mechanistic and Kinetic Study. ACS Omega. 2019 Nov 08;4(21):19375-19381. doi: 10.1021/acsomega.9b02782. eCollection 2019 Nov 19. PMID: 31763562; PMCID: PMC6868896.
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Targeting cancer stem cells by nutraceuticals for cancer therapy.

Seminars in cancer biology

Chu M, Zheng C, Chen C, Song G, Hu X, Wang ZW.
PMID: 34273521
Semin Cancer Biol. 2021 Jul 14; doi: 10.1016/j.semcancer.2021.07.008. Epub 2021 Jul 14.

Accumulating evidence has demonstrated that cancer stem cells (CSCs) play an essential role in tumor progression and reoccurrence and drug resistance. Multiple signaling pathways have been revealed to be critically participated in CSC development and maintenance. Emerging evidence indicates...

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Chu M, Zheng C, Chen C, et al. Targeting cancer stem cells by nutraceuticals for cancer therapy. Semin Cancer Biol. 2021;doi: 10.1016/j.semcancer.2021.07.008.
Chu, M., Zheng, C., Chen, C., Song, G., Hu, X., & Wang, Z. W. (2021). Targeting cancer stem cells by nutraceuticals for cancer therapy. Seminars in cancer biology, . https://doi.org/10.1016/j.semcancer.2021.07.008
Chu, Man, et al. "Targeting cancer stem cells by nutraceuticals for cancer therapy." Seminars in cancer biology vol. (2021). doi: https://doi.org/10.1016/j.semcancer.2021.07.008
Chu M, Zheng C, Chen C, Song G, Hu X, Wang ZW. Targeting cancer stem cells by nutraceuticals for cancer therapy. Semin Cancer Biol. 2021 Jul 14; doi: 10.1016/j.semcancer.2021.07.008. Epub 2021 Jul 14. PMID: 34273521.
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Neuroprotective effects of indole-3-carbinol on the rotenone rat model of Parkinson's disease: Impact of the SIRT1-AMPK signaling pathway.

Toxicology and applied pharmacology

Mohamad KA, El-Naga RN, Wahdan SA.
PMID: 34973289
Toxicol Appl Pharmacol. 2021 Dec 29;115853. doi: 10.1016/j.taap.2021.115853. Epub 2021 Dec 29.

Parkinson's disease (PD) is the second most common progressive neurodegenerative disorder. Although mounting studies have been conducted, no effective therapy is available to halt its progression. Indole-3-carbinol (I3C) is a naturally occurring compound obtained by β-thioglucosidase-mediated autolysis of glucobrassicin...

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Mohamad KA, El-Naga RN, Wahdan SA. Neuroprotective effects of indole-3-carbinol on the rotenone rat model of Parkinson's disease: Impact of the SIRT1-AMPK signaling pathway. Toxicol Appl Pharmacol. 2021;115853doi: 10.1016/j.taap.2021.115853.
Mohamad, K. A., El-Naga, R. N., & Wahdan, S. A. (2021). Neuroprotective effects of indole-3-carbinol on the rotenone rat model of Parkinson's disease: Impact of the SIRT1-AMPK signaling pathway. Toxicology and applied pharmacology, 115853. https://doi.org/10.1016/j.taap.2021.115853
Mohamad, Khalid A, et al. "Neuroprotective effects of indole-3-carbinol on the rotenone rat model of Parkinson's disease: Impact of the SIRT1-AMPK signaling pathway." Toxicology and applied pharmacology vol. (2021): 115853. doi: https://doi.org/10.1016/j.taap.2021.115853
Mohamad KA, El-Naga RN, Wahdan SA. Neuroprotective effects of indole-3-carbinol on the rotenone rat model of Parkinson's disease: Impact of the SIRT1-AMPK signaling pathway. Toxicol Appl Pharmacol. 2021 Dec 29;115853. doi: 10.1016/j.taap.2021.115853. Epub 2021 Dec 29. PMID: 34973289.
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Indole glucosinolates exhibit anti-inflammatory effects on Ehrlich ascites carcinoma cells through modulation of inflammatory markers and miRNAs.

Molecular biology reports

Salem AZ, Medhat D, Fathy SA, Mohamed MR, El-Khayat Z, El-Daly SM.
PMID: 34476740
Mol Biol Rep. 2021 Oct;48(10):6845-6855. doi: 10.1007/s11033-021-06683-5. Epub 2021 Sep 02.

BACKGROUND: Nuclear factor-κB (NF-κB) has been identified as the major link between inflammation and cancer. Natural agents that inhibit this pathway are essential in attenuating inflammation induced by cancer or chemotherapeutic drugs. High intake of Brassicaceae vegetables has been...

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Salem AZ, Medhat D, Fathy SA, et al. Indole glucosinolates exhibit anti-inflammatory effects on Ehrlich ascites carcinoma cells through modulation of inflammatory markers and miRNAs. Mol Biol Rep. 2021;48(10):6845-6855doi: 10.1007/s11033-021-06683-5.
Salem, A. Z., Medhat, D., Fathy, S. A., Mohamed, M. R., El-Khayat, Z., & El-Daly, S. M. (2021). Indole glucosinolates exhibit anti-inflammatory effects on Ehrlich ascites carcinoma cells through modulation of inflammatory markers and miRNAs. Molecular biology reports, 48(10), 6845-6855. https://doi.org/10.1007/s11033-021-06683-5
Salem, Ayah Z, et al. "Indole glucosinolates exhibit anti-inflammatory effects on Ehrlich ascites carcinoma cells through modulation of inflammatory markers and miRNAs." Molecular biology reports vol. 48,10 (2021): 6845-6855. doi: https://doi.org/10.1007/s11033-021-06683-5
Salem AZ, Medhat D, Fathy SA, Mohamed MR, El-Khayat Z, El-Daly SM. Indole glucosinolates exhibit anti-inflammatory effects on Ehrlich ascites carcinoma cells through modulation of inflammatory markers and miRNAs. Mol Biol Rep. 2021 Oct;48(10):6845-6855. doi: 10.1007/s11033-021-06683-5. Epub 2021 Sep 02. PMID: 34476740.
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Reaction of indoles with aromatic fluoromethyl ketones: an efficient synthesis of trifluoromethyl(indolyl)phenylmethanols using K.

Beilstein journal of organic chemistry

Pillaiyar T, Sedaghati M, Schnakenburg G.
PMID: 32395181
Beilstein J Org Chem. 2020 Apr 20;16:778-790. doi: 10.3762/bjoc.16.71. eCollection 2020.

A new, mild and efficient protocol for the synthesis of trifluoromethyl(indolyl)phenylmethanols by the reaction of indoles with a variety of aromatic fluoromethyl ketones in the presence of K

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Pillaiyar T, Sedaghati M, Schnakenburg G. Reaction of indoles with aromatic fluoromethyl ketones: an efficient synthesis of trifluoromethyl(indolyl)phenylmethanols using K. Beilstein J Org Chem. 2020;16:778-790doi: 10.3762/bjoc.16.71.
Pillaiyar, T., Sedaghati, M., & Schnakenburg, G. (2020). Reaction of indoles with aromatic fluoromethyl ketones: an efficient synthesis of trifluoromethyl(indolyl)phenylmethanols using K. Beilstein journal of organic chemistry, 16778-790. https://doi.org/10.3762/bjoc.16.71
Pillaiyar, Thanigaimalai, et al. "Reaction of indoles with aromatic fluoromethyl ketones: an efficient synthesis of trifluoromethyl(indolyl)phenylmethanols using K." Beilstein journal of organic chemistry vol. 16 (2020): 778-790. doi: https://doi.org/10.3762/bjoc.16.71
Pillaiyar T, Sedaghati M, Schnakenburg G. Reaction of indoles with aromatic fluoromethyl ketones: an efficient synthesis of trifluoromethyl(indolyl)phenylmethanols using K. Beilstein J Org Chem. 2020 Apr 20;16:778-790. doi: 10.3762/bjoc.16.71. eCollection 2020. PMID: 32395181; PMCID: PMC7189012.
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3,3'-Diindolylmethane Promotes BDNF and Antioxidant Enzyme Formation via TrkB/Akt Pathway Activation for Neuroprotection against Oxidative Stress-Induced Apoptosis in Hippocampal Neuronal Cells.

Antioxidants (Basel, Switzerland)

Lee BD, Yoo JM, Baek SY, Li FY, Sok DE, Kim MR.
PMID: 31861353
Antioxidants (Basel). 2019 Dec 18;9(1). doi: 10.3390/antiox9010003.

3,3'-Diindolylmethane (DIM), a metabolite of indole-3-carbinol present in Brassicaceae vegetables, possesses various health-promoting effects. Nonetheless, the effect of DIM on neurodegenerative diseases has not been elucidated clearly. In this study, we hypothesized DIM may protect neuronal cells against oxidative...

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Lee BD, Yoo JM, Baek SY, et al. 3,3'-Diindolylmethane Promotes BDNF and Antioxidant Enzyme Formation via TrkB/Akt Pathway Activation for Neuroprotection against Oxidative Stress-Induced Apoptosis in Hippocampal Neuronal Cells. Antioxidants (Basel). 2019;9(1)doi: 10.3390/antiox9010003.
Lee, B. D., Yoo, J. M., Baek, S. Y., Li, F. Y., Sok, D. E., & Kim, M. R. (2019). 3,3'-Diindolylmethane Promotes BDNF and Antioxidant Enzyme Formation via TrkB/Akt Pathway Activation for Neuroprotection against Oxidative Stress-Induced Apoptosis in Hippocampal Neuronal Cells. Antioxidants (Basel, Switzerland), 9(1), . https://doi.org/10.3390/antiox9010003
Lee, Bo Dam, et al. "3,3'-Diindolylmethane Promotes BDNF and Antioxidant Enzyme Formation via TrkB/Akt Pathway Activation for Neuroprotection against Oxidative Stress-Induced Apoptosis in Hippocampal Neuronal Cells." Antioxidants (Basel, Switzerland) vol. 9,1 (2019). doi: https://doi.org/10.3390/antiox9010003
Lee BD, Yoo JM, Baek SY, Li FY, Sok DE, Kim MR. 3,3'-Diindolylmethane Promotes BDNF and Antioxidant Enzyme Formation via TrkB/Akt Pathway Activation for Neuroprotection against Oxidative Stress-Induced Apoptosis in Hippocampal Neuronal Cells. Antioxidants (Basel). 2019 Dec 18;9(1). doi: 10.3390/antiox9010003. PMID: 31861353; PMCID: PMC7023184.
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A facile and sensitive HPLC-MS/MS method for quantification of 3,3'-diindolylmethane in plasma samples.

Biomedical chromatography : BMC

Lakeev AP, Yanovskaya EA, Tsuran DV, Bryushinina OS, Abdrashitova NY, Zyuz'kova YG, Udut VV, Kiselev VI, Kuznetsov IN.
PMID: 34875720
Biomed Chromatogr. 2021 Dec 07;e5296. doi: 10.1002/bmc.5296. Epub 2021 Dec 07.

Indole-3-carbinol is the subject of ongoing biomedical research owing to its potential antiatherogenic, anticarcinogenic and antioxidant effects. The antitumor properties are mainly associated with its major metabolite, i.e. 3,3'-diindolylmethane (DIM). Typically, the biological activity of the chemical compound is...

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Lakeev AP, Yanovskaya EA, Tsuran DV, et al. A facile and sensitive HPLC-MS/MS method for quantification of 3,3'-diindolylmethane in plasma samples. Biomed Chromatogr. 2021;e5296doi: 10.1002/bmc.5296.
Lakeev, A. P., Yanovskaya, E. A., Tsuran, D. V., Bryushinina, O. S., Abdrashitova, N. Y., Zyuz'kova, Y. G., Udut, V. V., Kiselev, V. I., & Kuznetsov, I. N. (2021). A facile and sensitive HPLC-MS/MS method for quantification of 3,3'-diindolylmethane in plasma samples. Biomedical chromatography : BMC, e5296. https://doi.org/10.1002/bmc.5296
Lakeev, Alexander P, et al. "A facile and sensitive HPLC-MS/MS method for quantification of 3,3'-diindolylmethane in plasma samples." Biomedical chromatography : BMC vol. (2021): e5296. doi: https://doi.org/10.1002/bmc.5296
Lakeev AP, Yanovskaya EA, Tsuran DV, Bryushinina OS, Abdrashitova NY, Zyuz'kova YG, Udut VV, Kiselev VI, Kuznetsov IN. A facile and sensitive HPLC-MS/MS method for quantification of 3,3'-diindolylmethane in plasma samples. Biomed Chromatogr. 2021 Dec 07;e5296. doi: 10.1002/bmc.5296. Epub 2021 Dec 07. PMID: 34875720.
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A comprehensive overview of the complex relationship between epigenetics, bioactive components, cancer, and aging.

Critical reviews in food science and nutrition

Kocabas Ş, Sanlier N.
PMID: 34623201
Crit Rev Food Sci Nutr. 2021 Oct 08;1-13. doi: 10.1080/10408398.2021.1986803. Epub 2021 Oct 08.

Among age-related diseases, the incidence of cancer increases significantly due to the overlap of some molecular pathways between cancer and aging. While the genetic influence on the human lifespan is estimated to be about 20-25%, epigenetic changes play an...

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Kocabas Ş, Sanlier N. A comprehensive overview of the complex relationship between epigenetics, bioactive components, cancer, and aging. Crit Rev Food Sci Nutr. 2021;1-13doi: 10.1080/10408398.2021.1986803.
Kocabas, �. �., & Sanlier, N. (2021). A comprehensive overview of the complex relationship between epigenetics, bioactive components, cancer, and aging. Critical reviews in food science and nutrition, 1-13. https://doi.org/10.1080/10408398.2021.1986803
Kocabas, Şule, and Sanlier, Nevin. "A comprehensive overview of the complex relationship between epigenetics, bioactive components, cancer, and aging." Critical reviews in food science and nutrition vol. (2021): 1-13. doi: https://doi.org/10.1080/10408398.2021.1986803
Kocabas Ş, Sanlier N. A comprehensive overview of the complex relationship between epigenetics, bioactive components, cancer, and aging. Crit Rev Food Sci Nutr. 2021 Oct 08;1-13. doi: 10.1080/10408398.2021.1986803. Epub 2021 Oct 08. PMID: 34623201.
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A systems pharmacology approach based on oncogenic signalling pathways to determine the mechanisms of action of natural products in breast cancer from transcriptome data.

BMC complementary medicine and therapies

Odongo R, Demiroglu-Zergeroglu A, Çakır T.
PMID: 34193143
BMC Complement Med Ther. 2021 Jun 30;21(1):181. doi: 10.1186/s12906-021-03340-z.

BACKGROUND: Narrow spectrum of action through limited molecular targets and unforeseen drug-related toxicities have been the main reasons for drug failures at the phase I clinical trials in complex diseases. Most plant-derived compounds with medicinal values possess poly-pharmacologic properties...

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Odongo R, Demiroglu-Zergeroglu A, Çakır T. A systems pharmacology approach based on oncogenic signalling pathways to determine the mechanisms of action of natural products in breast cancer from transcriptome data. BMC Complement Med Ther. 2021;21(1):181doi: 10.1186/s12906-021-03340-z.
Odongo, R., Demiroglu-Zergeroglu, A., & Çakır, T. (2021). A systems pharmacology approach based on oncogenic signalling pathways to determine the mechanisms of action of natural products in breast cancer from transcriptome data. BMC complementary medicine and therapies, 21(1), 181. https://doi.org/10.1186/s12906-021-03340-z
Odongo, Regan, et al. "A systems pharmacology approach based on oncogenic signalling pathways to determine the mechanisms of action of natural products in breast cancer from transcriptome data." BMC complementary medicine and therapies vol. 21,1 (2021): 181. doi: https://doi.org/10.1186/s12906-021-03340-z
Odongo R, Demiroglu-Zergeroglu A, Çakır T. A systems pharmacology approach based on oncogenic signalling pathways to determine the mechanisms of action of natural products in breast cancer from transcriptome data. BMC Complement Med Ther. 2021 Jun 30;21(1):181. doi: 10.1186/s12906-021-03340-z. PMID: 34193143; PMCID: PMC8244196.
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Showing 1 to 12 of 73 entries