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Synthesis, .

Acta pharmaceutica Sinica. B

Pang L, Liu CY, Gong GH, Quan ZS.
PMID: 32322467
Acta Pharm Sin B. 2020 Apr;10(4):628-645. doi: 10.1016/j.apsb.2019.09.002. Epub 2019 Sep 13.

Lappaconitine (LA), a natural compound with a novel C18-diterpenoid alkaloid skeleton, displayed extensive biological profile. Recent research on LA is focused mainly on its anti-tumor and analgesic effects, and therefore we aimed to investigate its anti-inflammatory potential. A series...

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Pang L, Liu CY, Gong GH, et al. Synthesis, . Acta Pharm Sin B. 2019;10(4):628-645doi: 10.1016/j.apsb.2019.09.002.
Pang, L., Liu, C. Y., Gong, G. H., & Quan, Z. S. (2020). Synthesis, . Acta pharmaceutica Sinica. B, 10(4), 628-645. https://doi.org/10.1016/j.apsb.2019.09.002
Pang, Lei, et al. "Synthesis, ." Acta pharmaceutica Sinica. B vol. 10,4 (2020): 628-645. doi: https://doi.org/10.1016/j.apsb.2019.09.002
Pang L, Liu CY, Gong GH, Quan ZS. Synthesis, . Acta Pharm Sin B. 2020 Apr;10(4):628-645. doi: 10.1016/j.apsb.2019.09.002. Epub 2019 Sep 13. PMID: 32322467; PMCID: PMC7161710.
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A photochemical approach for evaluating the reactivity of substituted lappaconitines.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

Ageeva AA, Khramtsova EA, Plyusnin VF, Stepanov AA, Leshina TV.
PMID: 29255820
Photochem Photobiol Sci. 2018 Feb 14;17(2):192-199. doi: 10.1039/c7pp00366h.

Lappaconitine (LC) is a natural diterpenoid alkaloid (DTA), acting as a human heart sodium channel blocker and possessing a wide range of biological activities, the cellular and molecular mechanisms of which are widely studied. This interest is due to...

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Ageeva AA, Khramtsova EA, Plyusnin VF, et al. A photochemical approach for evaluating the reactivity of substituted lappaconitines. Photochem Photobiol Sci. 2018;17(2):192-199doi: 10.1039/c7pp00366h.
Ageeva, A. A., Khramtsova, E. A., Plyusnin, V. F., Stepanov, A. A., & Leshina, T. V. (2018). A photochemical approach for evaluating the reactivity of substituted lappaconitines. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 17(2), 192-199. https://doi.org/10.1039/c7pp00366h
Ageeva, Aleksandra A, et al. "A photochemical approach for evaluating the reactivity of substituted lappaconitines." Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology vol. 17,2 (2018): 192-199. doi: https://doi.org/10.1039/c7pp00366h
Ageeva AA, Khramtsova EA, Plyusnin VF, Stepanov AA, Leshina TV. A photochemical approach for evaluating the reactivity of substituted lappaconitines. Photochem Photobiol Sci. 2018 Feb 14;17(2):192-199. doi: 10.1039/c7pp00366h. PMID: 29255820.
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Analgesic effects of lappaconitine in leukemia bone pain in a mouse model.

PeerJ

Zhu XC, Ge CT, Wang P, Zhang JL, Yu YY, Fu CY.
PMID: 26019998
PeerJ. 2015 May 07;3:e936. doi: 10.7717/peerj.936. eCollection 2015.

Bone pain is a common and severe symptom in cancer patients. The present study employed a mouse model of leukemia bone pain by injection K562 cells into tibia of mouse to evaluate the analgesic effects of lappacontine. Our results...

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Zhu XC, Ge CT, Wang P, et al. Analgesic effects of lappaconitine in leukemia bone pain in a mouse model. PeerJ. 2015;3:e936doi: 10.7717/peerj.936.
Zhu, X. C., Ge, C. T., Wang, P., Zhang, J. L., Yu, Y. Y., & Fu, C. Y. (2015). Analgesic effects of lappaconitine in leukemia bone pain in a mouse model. PeerJ, 3e936. https://doi.org/10.7717/peerj.936
Zhu, Xiao-Cui, et al. "Analgesic effects of lappaconitine in leukemia bone pain in a mouse model." PeerJ vol. 3 (2015): e936. doi: https://doi.org/10.7717/peerj.936
Zhu XC, Ge CT, Wang P, Zhang JL, Yu YY, Fu CY. Analgesic effects of lappaconitine in leukemia bone pain in a mouse model. PeerJ. 2015 May 07;3:e936. doi: 10.7717/peerj.936. eCollection 2015. PMID: 26019998; PMCID: PMC4435501.
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Hydrophobic lappaconitine loaded into iota-carrageenan by one step self-assembly.

Carbohydrate polymers

Sun W, Saldaña MDA, Zhao Y, Wu L, Dong T, Jin Y, Zhang J.
PMID: 26686125
Carbohydr Polym. 2016 Feb 10;137:231-238. doi: 10.1016/j.carbpol.2015.10.060. Epub 2015 Oct 17.

New data on the loading of pH-sensitive lappaconitine loaded into iota-carrageenan (LA-ICG) is provided. This LA-ICG ionic biopolymer was prepared by one step self-assembly. The LA-ICG was characterized in terms of the loading capacity, lappaconitine (LA) releasing behavior, pH-sensitivity,...

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Sun W, Saldaña MDA, Zhao Y, et al. Hydrophobic lappaconitine loaded into iota-carrageenan by one step self-assembly. Carbohydr Polym. 2015;137:231-238doi: 10.1016/j.carbpol.2015.10.060.
Sun, W., Saldaña, M. D. A., Zhao, Y., Wu, L., Dong, T., Jin, Y., & Zhang, J. (2016). Hydrophobic lappaconitine loaded into iota-carrageenan by one step self-assembly. Carbohydrate polymers, 137231-238. https://doi.org/10.1016/j.carbpol.2015.10.060
Sun, Wenxiu, et al. "Hydrophobic lappaconitine loaded into iota-carrageenan by one step self-assembly." Carbohydrate polymers vol. 137 (2016): 231-238. doi: https://doi.org/10.1016/j.carbpol.2015.10.060
Sun W, Saldaña MDA, Zhao Y, Wu L, Dong T, Jin Y, Zhang J. Hydrophobic lappaconitine loaded into iota-carrageenan by one step self-assembly. Carbohydr Polym. 2016 Feb 10;137:231-238. doi: 10.1016/j.carbpol.2015.10.060. Epub 2015 Oct 17. PMID: 26686125.
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Lappaconitine hydrochloride inhibits proliferation and induces apoptosis in human colon cancer HCT-116 cells via mitochondrial and MAPK pathway.

Acta histochemica

Song N, Ma J, Hu W, Guo Y, Hui L, Aamer M, Ma J.
PMID: 34058516
Acta Histochem. 2021 Jul;123(5):151736. doi: 10.1016/j.acthis.2021.151736. Epub 2021 May 29.

Lappaconitine hydrochloride (LH), as a new synthetic alkaloid, exhibits antitumor activity, whereas its antitumor effect on colorectal cancer (CRC) has not been investigated. In this study, the effect of LH on HCT-116 cell proliferation and apoptosis in vivo and...

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Song N, Ma J, Hu W, et al. Lappaconitine hydrochloride inhibits proliferation and induces apoptosis in human colon cancer HCT-116 cells via mitochondrial and MAPK pathway. Acta Histochem. 2021;123(5):151736doi: 10.1016/j.acthis.2021.151736.
Song, N., Ma, J., Hu, W., Guo, Y., Hui, L., Aamer, M., & Ma, J. (2021). Lappaconitine hydrochloride inhibits proliferation and induces apoptosis in human colon cancer HCT-116 cells via mitochondrial and MAPK pathway. Acta histochemica, 123(5), 151736. https://doi.org/10.1016/j.acthis.2021.151736
Song, Na, et al. "Lappaconitine hydrochloride inhibits proliferation and induces apoptosis in human colon cancer HCT-116 cells via mitochondrial and MAPK pathway." Acta histochemica vol. 123,5 (2021): 151736. doi: https://doi.org/10.1016/j.acthis.2021.151736
Song N, Ma J, Hu W, Guo Y, Hui L, Aamer M, Ma J. Lappaconitine hydrochloride inhibits proliferation and induces apoptosis in human colon cancer HCT-116 cells via mitochondrial and MAPK pathway. Acta Histochem. 2021 Jul;123(5):151736. doi: 10.1016/j.acthis.2021.151736. Epub 2021 May 29. PMID: 34058516.
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Alkaloids of Aconitum barbatum.

Planta medica

De-Quan Y, Das BC.
PMID: 17405023
Planta Med. 1983 Oct;49(10):85-9. doi: 10.1055/s-2007-969821.

Nine diterpenoid alkaloids were isolated from the roots of ACONITUM BARBATUM VAR. PUBERULUM. Five of them are known: ranaconitine ( 1) [1], lappaconitine ( 2) [2], septentriodine ( 3) [3], septentrionine ( 4) [3], and lycaconitine ( 5) [4]....

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De-Quan Y, Das BC. Alkaloids of Aconitum barbatum. Planta Med. 1983;49(10):85-9doi: 10.1055/s-2007-969821.
De-Quan, Y., & Das, B. C. (1983). Alkaloids of Aconitum barbatum. Planta medica, 49(10), 85-9. https://doi.org/10.1055/s-2007-969821
De-Quan, Y, and Das, B C. "Alkaloids of Aconitum barbatum." Planta medica vol. 49,10 (1983): 85-9. doi: https://doi.org/10.1055/s-2007-969821
De-Quan Y, Das BC. Alkaloids of Aconitum barbatum. Planta Med. 1983 Oct;49(10):85-9. doi: 10.1055/s-2007-969821. PMID: 17405023.
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Showing 1 to 6 of 6 entries