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Showing 1 to 12 of 60 entries
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Blockade of autophagy aggravates endoplasmic reticulum stress and improves Paclitaxel cytotoxicity in human cervical cancer cells.

Cancer research and treatment

Xu L, Liu JH, Zhang J, Zhang N, Wang ZH.
PMID: 25578058
Cancer Res Treat. 2015 Apr;47(2):313-21. doi: 10.4143/crt.2013.222. Epub 2014 Sep 11.

PURPOSE: Autophagy is one of the ways to degrade unfolded proteins after endoplasmic reticulum (ER) stress. The purpose of this study is to determine whether a blockade of autophagy leads to aggravated endoplasmic reticulum stress, which then induces cells...

Apelin-13 induces autophagy in hepatoma HepG2 cells through ERK1/2 signaling pathway-dependent upregulation of Beclin1.

Oncology letters

Huang Q, Liu X, Cao C, Lei J, Han D, Chen G, Yu J, Chen L, Lv D, Li Z.
PMID: 26893689
Oncol Lett. 2016 Feb;11(2):1051-1056. doi: 10.3892/ol.2015.3991. Epub 2015 Dec 03.

The aim of the present study was to investigate the effect of Apelin-13 on autophagy in hepatocellular carcinoma HepG2 cells and the underlying mechanism of the effect. The HepG2 cells were treated with Apelin-13 at a final concentration of...

Identification of the Large Subunit of Ribulose 1,5-Bisphosphate Carboxylase/Oxygenase as a Substrate for Transglutaminase in Medicago sativa L. (Alfalfa).

Plant physiology

Margosiak SA, Dharma A, Bruce-Carver MR, Gonzales AP, Louie D, Kuehn GD.
PMID: 16667270
Plant Physiol. 1990 Jan;92(1):88-96. doi: 10.1104/pp.92.1.88.

Extracts prepared from floral meristematic tissue of alfalfa (Medicago sativa L.) were investigated for expression of the enzyme transglutaminase in order to identify the major protein substrate for transglutaminase-directed modifications among plant proteins. The large polymorphic subunits of ribulose...

Curcumin induced autophagy anticancer effects on human lung adenocarcinoma cell line A549.

Oncology letters

Liu F, Gao S, Yang Y, Zhao X, Fan Y, Ma W, Yang D, Yang A, Yu Y.
PMID: 28928819
Oncol Lett. 2017 Sep;14(3):2775-2782. doi: 10.3892/ol.2017.6565. Epub 2017 Jul 08.

To investigate the anticancer effects of curcumin-induced autophagy and its effects on the human lung adenocarcinoma A549 cell line, inverted phase contrast microscopy was used to observe alterations to the cytomorphology of cells. An MTT assay was used to...

Pseudolaric acid B activates autophagy in MCF-7 human breast cancer cells to prevent cell death.

Oncology letters

Yu J, Chen C, Xu T, Yan M, Xue B, Wang Y, Liu C, Zhong T, Wang Z, Meng X, Hu D, Yu X.
PMID: 26998069
Oncol Lett. 2016 Mar;11(3):1731-1737. doi: 10.3892/ol.2016.4103. Epub 2016 Jan 14.

Pseudolaric acid B (PAB) has been demonstrated to exert antitumor effects in MCF-7 human breast cancer cells. The present study aimed to investigate the mechanism of resistance to PAB-induced cell death. Following incubation with 4 µM of PAB for...

Perilaldehyde activates AMP-activated protein kinase to suppress the growth of gastric cancer via induction of autophagy.

Journal of cellular biochemistry

Zhang Y, Liu S, Feng Q, Huang X, Wang X, Peng Y, Zhao Z, Liu Z.
PMID: 30378150
J Cell Biochem. 2018 Oct 30; doi: 10.1002/jcb.27491. Epub 2018 Oct 30.

BACKGROUND AND AIM: Perillaldehyde (PAH), one of the major oil components in Perilla frutescens, is very critical to health maintenance, for a wide range of human chronic diseases, including cancers. AMP-activated protein kinase (AMPK) has been implicated in the...

Protective effects of naringin on glucocorticoid-induced osteoporosis through regulating the PI3K/Akt/mTOR signaling pathway.

American journal of translational research

Ge X, Zhou G.
PMID: 34306372
Am J Transl Res. 2021 Jun 15;13(6):6330-6341. eCollection 2021.

OBJECTIVE: To investigate the protective effects of Naringin on glucocorticoid-induced osteoporosis (GIOP) through the PI3K/AKT/mTOR signaling pathway in vivo and in vitro.METHODS: Osteoblasts were cultured from the differentiated bone marrow mesenchymal stem cells (BM-MSCs) and were grouped as follows:...

Overexpression of long non-coding RNA WT1-AS or silencing of PIK3AP1 are inhibitory to cervical cancer progression.

Cell cycle (Georgetown, Tex.)

Tong W, Zhang H.
PMID: 34839795
Cell Cycle. 2021 Dec;20(24):2583-2596. doi: 10.1080/15384101.2021.1991106. Epub 2021 Nov 28.

Accumulating evidence demonstrate that long non-coding RNAs (lncRNAs) play an important role in regulating the biological function of cervical cancer cells. However, the regulatory role of lncRNA Wilms tumor 1 homolog antisense RNA (WT1-AS) in cervical cancer cells remains...

Muyin extract inhibits non-small-cell lung cancer growth by inducing autophagy and apoptosis in vitro and in vivo.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Kan Y, Song M, Cui X, Yang Q, Zang Y, Li Q, Li Y, Cai W, Chen Y, Weng X, Wang Y, Zhu X.
PMID: 34952294
Phytomedicine. 2021 Oct 31;96:153834. doi: 10.1016/j.phymed.2021.153834. Epub 2021 Oct 31.

BACKGROUND: Non-small cell lung cancer (NSCLC) is a major subtype of lung cancer with a higher mortality rate. Both apoptosis and autophagy are crucial processes in the pathophysiology of NSCLC. Muyin extract (MSE) is a combination of Momordica cochinchinensis...

Downregulation of microRNA-96-5p protects TM3 cells against zearalenone toxicity via targeting ATG9A.

Experimental and therapeutic medicine

Xu X, Xu X, Zheng Y, Xu L.
PMID: 34584554
Exp Ther Med. 2021 Nov;22(5):1209. doi: 10.3892/etm.2021.10643. Epub 2021 Aug 24.

Male infertility factor accounts for ~50% of all infertility cases, and traditional treatments for male infertility are limited. The association between the dysfunction of Leydig cells and hypospermatogenesis is essential for developing novel treatment methods for male infertility. It...

Artesunate induces apoptosis, autophagy and ferroptosis in diffuse large B cell lymphoma cells by impairing STAT3 signaling.

Cellular signalling

Chen Y, Wang F, Wu P, Gong S, Gao J, Tao H, Shen Q, Wang S, Zhou Z, Jia Y.
PMID: 34628002
Cell Signal. 2021 Dec;88:110167. doi: 10.1016/j.cellsig.2021.110167. Epub 2021 Oct 07.

Artesunate (ART), a water-soluble derivative of artemisinin, has been reported to exert antineoplastic effects via diverse mechanisms in various types of cancer. Therefore, understanding the underlying mechanism of action of ART in distinct cancer types is indispensable to optimizing...

The exogenous autophagy inducement alleviated the sea cucumber (Stichopus japonicus) autolysis with exposure to stress stimuli of ultraviolet light.

Journal of the science of food and agriculture

Sun J, Zheng J, Wang Y, Yang S, Yang J.
PMID: 34825382
J Sci Food Agric. 2021 Nov 26; doi: 10.1002/jsfa.11689. Epub 2021 Nov 26.

BACKGROUND: Autolysis is the most important restrictive factor for the live sea cucumber trade and commercial transportation. Thus, it is essential to investigate the mechanism of autolysis activation or deactivation in the sea cucumber. In this study, monodansylcadaverine staining...

Showing 1 to 12 of 60 entries