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Effects of C2-Ceramide and Oltipraz on Hepatocyte Nuclear Factor-1 and Glutathione S-Transferase A1 in Acetaminophen-Mediated Acute Mice Liver Injury.

Frontiers in pharmacology

Ma X, Chang Y, Zhang Y, Muhammad I, Shi C, Li R, Li C, Li Z, Lin Y, Han Q, Liu F.
PMID: 30254584
Front Pharmacol. 2018 Sep 11;9:1009. doi: 10.3389/fphar.2018.01009. eCollection 2018.

In this study, acetaminophen (APAP)-induced acute liver injury mice model was used to investigate the effects of C2-ceramide and oltipraz on hepatocyte nuclear factor 1 (HNF-1) and glutathione S-transferase A1 (GSTA1). Notably, C2-ceramide caused alteration in mice serum transaminases...

Cite
Ma X, Chang Y, Zhang Y, et al. Effects of C2-Ceramide and Oltipraz on Hepatocyte Nuclear Factor-1 and Glutathione S-Transferase A1 in Acetaminophen-Mediated Acute Mice Liver Injury. Front Pharmacol. 2018;9:1009doi: 10.3389/fphar.2018.01009.
Ma, X., Chang, Y., Zhang, Y., Muhammad, I., Shi, C., Li, R., Li, C., Li, Z., Lin, Y., Han, Q., & Liu, F. (2018). Effects of C2-Ceramide and Oltipraz on Hepatocyte Nuclear Factor-1 and Glutathione S-Transferase A1 in Acetaminophen-Mediated Acute Mice Liver Injury. Frontiers in pharmacology, 91009. https://doi.org/10.3389/fphar.2018.01009
Ma, Xin, et al. "Effects of C2-Ceramide and Oltipraz on Hepatocyte Nuclear Factor-1 and Glutathione S-Transferase A1 in Acetaminophen-Mediated Acute Mice Liver Injury." Frontiers in pharmacology vol. 9 (2018): 1009. doi: https://doi.org/10.3389/fphar.2018.01009
Ma X, Chang Y, Zhang Y, Muhammad I, Shi C, Li R, Li C, Li Z, Lin Y, Han Q, Liu F. Effects of C2-Ceramide and Oltipraz on Hepatocyte Nuclear Factor-1 and Glutathione S-Transferase A1 in Acetaminophen-Mediated Acute Mice Liver Injury. Front Pharmacol. 2018 Sep 11;9:1009. doi: 10.3389/fphar.2018.01009. eCollection 2018. PMID: 30254584; PMCID: PMC6141969.
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Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency.

Free radical biology & medicine

Yang R, Zhang J, Li J, Qin R, Chen J, Wang R, Goltzman D, Miao D.
PMID: 34890768
Free Radic Biol Med. 2022 Jan;178:246-261. doi: 10.1016/j.freeradbiomed.2021.12.010. Epub 2021 Dec 08.

Previous studies have shown that 1,25(OH)

Cite
Yang R, Zhang J, Li J, et al. Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency. Free Radic Biol Med. 2021;178:246-261doi: 10.1016/j.freeradbiomed.2021.12.010.
Yang, R., Zhang, J., Li, J., Qin, R., Chen, J., Wang, R., Goltzman, D., & Miao, D. (2022). Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency. Free radical biology & medicine, 178246-261. https://doi.org/10.1016/j.freeradbiomed.2021.12.010
Yang, Renlei, et al. "Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency." Free radical biology & medicine vol. 178 (2022): 246-261. doi: https://doi.org/10.1016/j.freeradbiomed.2021.12.010
Yang R, Zhang J, Li J, Qin R, Chen J, Wang R, Goltzman D, Miao D. Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency. Free Radic Biol Med. 2022 Jan;178:246-261. doi: 10.1016/j.freeradbiomed.2021.12.010. Epub 2021 Dec 08. PMID: 34890768.
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Drug-induced liver injury: Oltipraz and C2-ceramide intervene HNF-1α/GSTA1 expression via JNK signaling pathway.

Journal of applied toxicology : JAT

Zhang Y, Ma B, Hao S, Wang J, Zhang R, Ishfaq M, Shi C, Yuan L, Li R, Li C, Liu F.
PMID: 33959992
J Appl Toxicol. 2021 Dec;41(12):2011-2020. doi: 10.1002/jat.4181. Epub 2021 May 06.

Drug-induced liver injury (DILI) is a serious and frequently occurring issue in drug development. The c-Jun N-terminal kinase (JNK) signaling pathway plays an important role in many diseases; hepatocyte nuclear factor-1α (HNF-1α) and glutathione S-transferase A1 (GSTA1) are important...

Cite
Zhang Y, Ma B, Hao S, et al. Drug-induced liver injury: Oltipraz and C2-ceramide intervene HNF-1α/GSTA1 expression via JNK signaling pathway. J Appl Toxicol. 2021;41(12):2011-2020doi: 10.1002/jat.4181.
Zhang, Y., Ma, B., Hao, S., Wang, J., Zhang, R., Ishfaq, M., Shi, C., Yuan, L., Li, R., Li, C., & Liu, F. (2021). Drug-induced liver injury: Oltipraz and C2-ceramide intervene HNF-1α/GSTA1 expression via JNK signaling pathway. Journal of applied toxicology : JAT, 41(12), 2011-2020. https://doi.org/10.1002/jat.4181
Zhang, Yuanyuan, et al. "Drug-induced liver injury: Oltipraz and C2-ceramide intervene HNF-1α/GSTA1 expression via JNK signaling pathway." Journal of applied toxicology : JAT vol. 41,12 (2021): 2011-2020. doi: https://doi.org/10.1002/jat.4181
Zhang Y, Ma B, Hao S, Wang J, Zhang R, Ishfaq M, Shi C, Yuan L, Li R, Li C, Liu F. Drug-induced liver injury: Oltipraz and C2-ceramide intervene HNF-1α/GSTA1 expression via JNK signaling pathway. J Appl Toxicol. 2021 Dec;41(12):2011-2020. doi: 10.1002/jat.4181. Epub 2021 May 06. PMID: 33959992.
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Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency.

Free radical biology & medicine

Yang R, Zhang J, Li J, Qin R, Chen J, Wang R, Goltzman D, Miao D.
PMID: 34890768
Free Radic Biol Med. 2021 Dec 08;178:246-261. doi: 10.1016/j.freeradbiomed.2021.12.010. Epub 2021 Dec 08.

Previous studies have shown that 1,25(OH)

Cite
Yang R, Zhang J, Li J, et al. Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency. Free Radic Biol Med. 2021;178:246-261doi: 10.1016/j.freeradbiomed.2021.12.010.
Yang, R., Zhang, J., Li, J., Qin, R., Chen, J., Wang, R., Goltzman, D., & Miao, D. (2021). Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency. Free radical biology & medicine, 178246-261. https://doi.org/10.1016/j.freeradbiomed.2021.12.010
Yang, Renlei, et al. "Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency." Free radical biology & medicine vol. 178 (2021): 246-261. doi: https://doi.org/10.1016/j.freeradbiomed.2021.12.010
Yang R, Zhang J, Li J, Qin R, Chen J, Wang R, Goltzman D, Miao D. Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency. Free Radic Biol Med. 2021 Dec 08;178:246-261. doi: 10.1016/j.freeradbiomed.2021.12.010. Epub 2021 Dec 08. PMID: 34890768.
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Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency.

Free radical biology & medicine

Yang R, Zhang J, Li J, Qin R, Chen J, Wang R, Goltzman D, Miao D.
PMID: 34890768
Free Radic Biol Med. 2021 Dec 08;178:246-261. doi: 10.1016/j.freeradbiomed.2021.12.010. Epub 2021 Dec 08.

Previous studies have shown that 1,25(OH)

Cite
Yang R, Zhang J, Li J, et al. Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency. Free Radic Biol Med. 2021;178:246-261doi: 10.1016/j.freeradbiomed.2021.12.010.
Yang, R., Zhang, J., Li, J., Qin, R., Chen, J., Wang, R., Goltzman, D., & Miao, D. (2021). Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency. Free radical biology & medicine, 178246-261. https://doi.org/10.1016/j.freeradbiomed.2021.12.010
Yang, Renlei, et al. "Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency." Free radical biology & medicine vol. 178 (2021): 246-261. doi: https://doi.org/10.1016/j.freeradbiomed.2021.12.010
Yang R, Zhang J, Li J, Qin R, Chen J, Wang R, Goltzman D, Miao D. Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency. Free Radic Biol Med. 2021 Dec 08;178:246-261. doi: 10.1016/j.freeradbiomed.2021.12.010. Epub 2021 Dec 08. PMID: 34890768.
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Strategy and planning for chemopreventive drug development: clinical development plans. Chemoprevention Branch and Agent Development Committee. National Cancer Institute.

Journal of cellular biochemistry. Supplement

Kelloff GJ, Crowell JA, Boone CW, Steele VE, Lubet RA, Greenwald P, Alberts DS, Covey JM, Doody LA, Knapp GG.
PMID: 7616753
J Cell Biochem Suppl. 1994;20:55-62. doi: 10.1002/jcb.240560906.

At the National Cancer Institute, Division of Cancer Prevention and Control, the Chemoprevention Branch and Agent Development Committee develop strategies for efficiently identifying, procuring, and advancing the most promising drugs into clinical trials. Scientific expertise is applied at each...

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Kelloff GJ, Crowell JA, Boone CW, et al. Strategy and planning for chemopreventive drug development: clinical development plans. Chemoprevention Branch and Agent Development Committee. National Cancer Institute. J Cell Biochem Suppl. 1994;20:55-62doi: 10.1002/jcb.240560906.
Kelloff, G. J., Crowell, J. A., Boone, C. W., Steele, V. E., Lubet, R. A., Greenwald, P., Alberts, D. S., Covey, J. M., Doody, L. A., & Knapp, G. G. (1994). Strategy and planning for chemopreventive drug development: clinical development plans. Chemoprevention Branch and Agent Development Committee. National Cancer Institute. Journal of cellular biochemistry. Supplement, 2055-62. https://doi.org/10.1002/jcb.240560906
Kelloff, G J, et al. "Strategy and planning for chemopreventive drug development: clinical development plans. Chemoprevention Branch and Agent Development Committee. National Cancer Institute." Journal of cellular biochemistry. Supplement vol. 20 (1994): 55-62. doi: https://doi.org/10.1002/jcb.240560906
Kelloff GJ, Crowell JA, Boone CW, Steele VE, Lubet RA, Greenwald P, Alberts DS, Covey JM, Doody LA, Knapp GG. Strategy and planning for chemopreventive drug development: clinical development plans. Chemoprevention Branch and Agent Development Committee. National Cancer Institute. J Cell Biochem Suppl. 1994;20:55-62. doi: 10.1002/jcb.240560906. PMID: 7616753.
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Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency.

Free radical biology & medicine

Yang R, Zhang J, Li J, Qin R, Chen J, Wang R, Goltzman D, Miao D.
PMID: 34890768
Free Radic Biol Med. 2021 Dec 08;178:246-261. doi: 10.1016/j.freeradbiomed.2021.12.010. Epub 2021 Dec 08.

Previous studies have shown that 1,25(OH)

Cite
Yang R, Zhang J, Li J, et al. Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency. Free Radic Biol Med. 2021;178:246-261doi: 10.1016/j.freeradbiomed.2021.12.010.
Yang, R., Zhang, J., Li, J., Qin, R., Chen, J., Wang, R., Goltzman, D., & Miao, D. (2021). Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency. Free radical biology & medicine, 178246-261. https://doi.org/10.1016/j.freeradbiomed.2021.12.010
Yang, Renlei, et al. "Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency." Free radical biology & medicine vol. 178 (2021): 246-261. doi: https://doi.org/10.1016/j.freeradbiomed.2021.12.010
Yang R, Zhang J, Li J, Qin R, Chen J, Wang R, Goltzman D, Miao D. Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency. Free Radic Biol Med. 2021 Dec 08;178:246-261. doi: 10.1016/j.freeradbiomed.2021.12.010. Epub 2021 Dec 08. PMID: 34890768.
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G.

Oncology letters

Lin J, Zhang L, Wang Z, Guan Q, Bao K, Wu L.
PMID: 34671429
Oncol Lett. 2021 Dec;22(6):815. doi: 10.3892/ol.2021.13076. Epub 2021 Sep 28.

The combretastatin A-4/oltipraz hybrid (COH), 5-(3-amino-4-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-3

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Lin J, Zhang L, Wang Z, et al. G. Oncol Lett. 2021;22(6):815doi: 10.3892/ol.2021.13076.
Lin, J., Zhang, L., Wang, Z., Guan, Q., Bao, K., & Wu, L. (2021). G. Oncology letters, 22(6), 815. https://doi.org/10.3892/ol.2021.13076
Lin, Jihong, et al. "G." Oncology letters vol. 22,6 (2021): 815. doi: https://doi.org/10.3892/ol.2021.13076
Lin J, Zhang L, Wang Z, Guan Q, Bao K, Wu L. G. Oncol Lett. 2021 Dec;22(6):815. doi: 10.3892/ol.2021.13076. Epub 2021 Sep 28. PMID: 34671429; PMCID: PMC8503807.
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CoCrMo-Nanoparticles induced peri-implant osteolysis by promoting osteoblast ferroptosis via regulating Nrf2-ARE signalling pathway.

Cell proliferation

Xu Y, Sang W, Zhong Y, Xue S, Yang M, Wang C, Lu H, Huan R, Mao X, Zhu L, He C, Ma J.
PMID: 34632658
Cell Prolif. 2021 Oct 11;e13142. doi: 10.1111/cpr.13142. Epub 2021 Oct 11.

OBJECTIVES: Aseptic loosening (AL) is the most common reason of total hip arthroplasty (THA) failure and revision surgery. Osteolysis, caused by wear particles released from implant surfaces, has a vital role in AL. Although previous studies suggest that wear...

Cite
Xu Y, Sang W, Zhong Y, et al. CoCrMo-Nanoparticles induced peri-implant osteolysis by promoting osteoblast ferroptosis via regulating Nrf2-ARE signalling pathway. Cell Prolif. 2021;e13142doi: 10.1111/cpr.13142.
Xu, Y., Sang, W., Zhong, Y., Xue, S., Yang, M., Wang, C., Lu, H., Huan, R., Mao, X., Zhu, L., He, C., & Ma, J. (2021). CoCrMo-Nanoparticles induced peri-implant osteolysis by promoting osteoblast ferroptosis via regulating Nrf2-ARE signalling pathway. Cell proliferation, e13142. https://doi.org/10.1111/cpr.13142
Xu, Yiming, et al. "CoCrMo-Nanoparticles induced peri-implant osteolysis by promoting osteoblast ferroptosis via regulating Nrf2-ARE signalling pathway." Cell proliferation vol. (2021): e13142. doi: https://doi.org/10.1111/cpr.13142
Xu Y, Sang W, Zhong Y, Xue S, Yang M, Wang C, Lu H, Huan R, Mao X, Zhu L, He C, Ma J. CoCrMo-Nanoparticles induced peri-implant osteolysis by promoting osteoblast ferroptosis via regulating Nrf2-ARE signalling pathway. Cell Prolif. 2021 Oct 11;e13142. doi: 10.1111/cpr.13142. Epub 2021 Oct 11. PMID: 34632658.
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Drug-induced liver injury: Oltipraz and C2-ceramide intervene HNF-1α/GSTA1 expression via JNK signaling pathway.

Journal of applied toxicology : JAT

Zhang Y, Ma B, Hao S, Wang J, Zhang R, Ishfaq M, Shi C, Yuan L, Li R, Li C, Liu F.
PMID: 33959992
J Appl Toxicol. 2021 Dec;41(12):2011-2020. doi: 10.1002/jat.4181. Epub 2021 May 06.

Drug-induced liver injury (DILI) is a serious and frequently occurring issue in drug development. The c-Jun N-terminal kinase (JNK) signaling pathway plays an important role in many diseases; hepatocyte nuclear factor-1α (HNF-1α) and glutathione S-transferase A1 (GSTA1) are important...

Cite
Zhang Y, Ma B, Hao S, et al. Drug-induced liver injury: Oltipraz and C2-ceramide intervene HNF-1α/GSTA1 expression via JNK signaling pathway. J Appl Toxicol. 2021;41(12):2011-2020doi: 10.1002/jat.4181.
Zhang, Y., Ma, B., Hao, S., Wang, J., Zhang, R., Ishfaq, M., Shi, C., Yuan, L., Li, R., Li, C., & Liu, F. (2021). Drug-induced liver injury: Oltipraz and C2-ceramide intervene HNF-1α/GSTA1 expression via JNK signaling pathway. Journal of applied toxicology : JAT, 41(12), 2011-2020. https://doi.org/10.1002/jat.4181
Zhang, Yuanyuan, et al. "Drug-induced liver injury: Oltipraz and C2-ceramide intervene HNF-1α/GSTA1 expression via JNK signaling pathway." Journal of applied toxicology : JAT vol. 41,12 (2021): 2011-2020. doi: https://doi.org/10.1002/jat.4181
Zhang Y, Ma B, Hao S, Wang J, Zhang R, Ishfaq M, Shi C, Yuan L, Li R, Li C, Liu F. Drug-induced liver injury: Oltipraz and C2-ceramide intervene HNF-1α/GSTA1 expression via JNK signaling pathway. J Appl Toxicol. 2021 Dec;41(12):2011-2020. doi: 10.1002/jat.4181. Epub 2021 May 06. PMID: 33959992.
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Protective effect of oltipraz in testicular ischaemia/reperfusion injury: An experimental study.

Andrologia

Can O, Canat L, Eraldemir FC, Acar E, Yildirim F, Sonmez K, Otunctemur A, Altunrende F.
PMID: 34514606
Andrologia. 2022 Feb;54(1):e14245. doi: 10.1111/and.14245. Epub 2021 Sep 12.

Testicular torsion is an emergency urological disease, and the treatment is immediate surgery. Despite emergency surgery, testicular damage may occur due to reperfusion. Therefore, a medical treatment to prevent this damage may be a rational idea. We aimed to...

Cite
Can O, Canat L, Eraldemir FC, et al. Protective effect of oltipraz in testicular ischaemia/reperfusion injury: An experimental study. Andrologia. 2021;54(1):e14245doi: 10.1111/and.14245.
Can, O., Canat, L., Eraldemir, F. C., Acar, E., Yildirim, F., Sonmez, K., Otunctemur, A., & Altunrende, F. (2022). Protective effect of oltipraz in testicular ischaemia/reperfusion injury: An experimental study. Andrologia, 54(1), e14245. https://doi.org/10.1111/and.14245
Can, Osman, et al. "Protective effect of oltipraz in testicular ischaemia/reperfusion injury: An experimental study." Andrologia vol. 54,1 (2022): e14245. doi: https://doi.org/10.1111/and.14245
Can O, Canat L, Eraldemir FC, Acar E, Yildirim F, Sonmez K, Otunctemur A, Altunrende F. Protective effect of oltipraz in testicular ischaemia/reperfusion injury: An experimental study. Andrologia. 2022 Feb;54(1):e14245. doi: 10.1111/and.14245. Epub 2021 Sep 12. PMID: 34514606.
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Anticancer activity and chemoprevention of xenobiotic organosulfurs in preclinical model systems.

Oncology discovery

Click RE.
PMID: 25383193
Oncol Discov. 2013;1(4). doi: 10.7243/2052-6199-1-4.

There seems to be little doubt that xenobiotic and plant derived organosulfur compounds have enormous benefits for in vitro cellular functions and for a multitude of diseases, including cancer. Since there are numerous reviews on anticancer activities of plant...

Cite
Click RE. Anticancer activity and chemoprevention of xenobiotic organosulfurs in preclinical model systems. Oncol Discov. 2013;1(4)doi: 10.7243/2052-6199-1-4.
Click, R. E. (2013). Anticancer activity and chemoprevention of xenobiotic organosulfurs in preclinical model systems. Oncology discovery, 1(4), . https://doi.org/10.7243/2052-6199-1-4
Click, Robert E. "Anticancer activity and chemoprevention of xenobiotic organosulfurs in preclinical model systems." Oncology discovery vol. 1,4 (2013). doi: https://doi.org/10.7243/2052-6199-1-4
Click RE. Anticancer activity and chemoprevention of xenobiotic organosulfurs in preclinical model systems. Oncol Discov. 2013;1(4). doi: 10.7243/2052-6199-1-4. PMID: 25383193; PMCID: PMC4222532.
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Showing 1 to 12 of 33 entries