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Parecoxib Provides Analgesic and Opioid-Sparing Effects Following Major Orthopedic Surgery: A Subset Analysis of a Randomized, Placebo-Controlled Clinical Trial.

Pain and therapy

Diaz-Borjon E, Torres-Gomez A, Essex MN, Salomon P, Li C, Cheung R, Parsons B.
PMID: 28255955
Pain Ther. 2017 Jun;6(1):61-72. doi: 10.1007/s40122-017-0066-5. Epub 2017 Mar 02.

INTRODUCTION: Orthopedic surgeries are among the most common and most painful surgeries performed. A multimodal analgesic approach is recommended to reduce opioid consumption, provide effective pain relief, and improve outcomes following surgery. This study examined the efficacy and opioid-sparing...

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Diaz-Borjon E, Torres-Gomez A, Essex MN, et al. Parecoxib Provides Analgesic and Opioid-Sparing Effects Following Major Orthopedic Surgery: A Subset Analysis of a Randomized, Placebo-Controlled Clinical Trial. Pain Ther. 2017;6(1):61-72doi: 10.1007/s40122-017-0066-5.
Diaz-Borjon, E., Torres-Gomez, A., Essex, M. N., Salomon, P., Li, C., Cheung, R., & Parsons, B. (2017). Parecoxib Provides Analgesic and Opioid-Sparing Effects Following Major Orthopedic Surgery: A Subset Analysis of a Randomized, Placebo-Controlled Clinical Trial. Pain and therapy, 6(1), 61-72. https://doi.org/10.1007/s40122-017-0066-5
Diaz-Borjon, Efrain, et al. "Parecoxib Provides Analgesic and Opioid-Sparing Effects Following Major Orthopedic Surgery: A Subset Analysis of a Randomized, Placebo-Controlled Clinical Trial." Pain and therapy vol. 6,1 (2017): 61-72. doi: https://doi.org/10.1007/s40122-017-0066-5
Diaz-Borjon E, Torres-Gomez A, Essex MN, Salomon P, Li C, Cheung R, Parsons B. Parecoxib Provides Analgesic and Opioid-Sparing Effects Following Major Orthopedic Surgery: A Subset Analysis of a Randomized, Placebo-Controlled Clinical Trial. Pain Ther. 2017 Jun;6(1):61-72. doi: 10.1007/s40122-017-0066-5. Epub 2017 Mar 02. PMID: 28255955; PMCID: PMC5447543.
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Continuous postoperative infusion of remifentanil inhibits the stress responses to tracheal extubation of patients under general anesthesia.

Journal of pain research

Zhao G, Yin X, Li Y, Shao J.
PMID: 28458576
J Pain Res. 2017 Apr 19;10:933-939. doi: 10.2147/JPR.S123423. eCollection 2017.

PURPOSE: The study aimed to assess the combined effects of parecoxib with three different doses of remifentanil and its effect on the stress and cough responses following tracheal extubation under general anesthesia.METHODS: A total of 120 patients with American...

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Zhao G, Yin X, Li Y, et al. Continuous postoperative infusion of remifentanil inhibits the stress responses to tracheal extubation of patients under general anesthesia. J Pain Res. 2017;10:933-939doi: 10.2147/JPR.S123423.
Zhao, G., Yin, X., Li, Y., & Shao, J. (2017). Continuous postoperative infusion of remifentanil inhibits the stress responses to tracheal extubation of patients under general anesthesia. Journal of pain research, 10933-939. https://doi.org/10.2147/JPR.S123423
Zhao, Guoliang, et al. "Continuous postoperative infusion of remifentanil inhibits the stress responses to tracheal extubation of patients under general anesthesia." Journal of pain research vol. 10 (2017): 933-939. doi: https://doi.org/10.2147/JPR.S123423
Zhao G, Yin X, Li Y, Shao J. Continuous postoperative infusion of remifentanil inhibits the stress responses to tracheal extubation of patients under general anesthesia. J Pain Res. 2017 Apr 19;10:933-939. doi: 10.2147/JPR.S123423. eCollection 2017. PMID: 28458576; PMCID: PMC5402994.
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Oral valdecoxib and injected parecoxib for acute postoperative pain: a quantitative systematic review.

BMC anesthesiology

Barden J, Edwards JE, McQuay HJ, Moore RA.
PMID: 12854974
BMC Anesthesiol. 2003 Jul 10;3(1):1. doi: 10.1186/1471-2253-3-1.

BACKGROUND: Clinical trials suggest that cyclo-oxygenase-2 specific inhibitors (coxibs) are an effective treatment for acute postoperative pain. The aims of this systematic review were to examine the evidence for oral valdecoxib and injected parecoxib, and quantify efficacy and adverse...

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Barden J, Edwards JE, McQuay HJ, et al. Oral valdecoxib and injected parecoxib for acute postoperative pain: a quantitative systematic review. BMC Anesthesiol. 2003;3(1):1doi: 10.1186/1471-2253-3-1.
Barden, J., Edwards, J. E., McQuay, H. J., & Moore, R. A. (2003). Oral valdecoxib and injected parecoxib for acute postoperative pain: a quantitative systematic review. BMC anesthesiology, 3(1), 1. https://doi.org/10.1186/1471-2253-3-1
Barden, Jodie, et al. "Oral valdecoxib and injected parecoxib for acute postoperative pain: a quantitative systematic review." BMC anesthesiology vol. 3,1 (2003): 1. doi: https://doi.org/10.1186/1471-2253-3-1
Barden J, Edwards JE, McQuay HJ, Moore RA. Oral valdecoxib and injected parecoxib for acute postoperative pain: a quantitative systematic review. BMC Anesthesiol. 2003 Jul 10;3(1):1. doi: 10.1186/1471-2253-3-1. PMID: 12854974; PMCID: PMC169173.
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[Functional rehabilitation and analgesia with botulinum toxin A in upper limb complex regional pain syndrome type I: case reports.].

Revista brasileira de anestesiologia

Lauretti GR, Veloso Fdos S, Mattos AL.
PMID: 19471824
Rev Bras Anestesiol. 2005 Apr;55(2):207-11. doi: 10.1590/s0034-70942005000200007.

BACKGROUND AND OBJECTIVES: Functional inability of the affected limb is often added to alodynia and hyperalgesia in Complex Regional Pain Syndrome (CRPS) type I. Two CRPS cases are reported in which botulinum toxin A as coadjuvant drug has contributed...

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Lauretti GR, Veloso Fdos S, Mattos AL. Reabilitação funcional e analgesia com uso de toxina botulínica A na síndrome dolorosa regional complexa tipo I do membro superior: relato de casos. [Functional rehabilitation and analgesia with botulinum toxin A in upper limb complex regional pain syndrome type I: case reports.]. Rev Bras Anestesiol. 2005;55(2):207-11doi: 10.1590/s0034-70942005000200007.
Lauretti, G. R., Veloso, F. d. o. s. . S., & Mattos, A. L. (2005). Reabilitação funcional e analgesia com uso de toxina botulínica A na síndrome dolorosa regional complexa tipo I do membro superior: relato de casos. [Functional rehabilitation and analgesia with botulinum toxin A in upper limb complex regional pain syndrome type I: case reports.]. Revista brasileira de anestesiologia, 55(2), 207-11. https://doi.org/10.1590/s0034-70942005000200007
Lauretti, Gabriela Rocha, et al. "Reabilitação funcional e analgesia com uso de toxina botulínica A na síndrome dolorosa regional complexa tipo I do membro superior: relato de casos." [Functional rehabilitation and analgesia with botulinum toxin A in upper limb complex regional pain syndrome type I: case reports.]. Revista brasileira de anestesiologia vol. 55,2 (2005): 207-11. doi: https://doi.org/10.1590/s0034-70942005000200007
Lauretti GR, Veloso Fdos S, Mattos AL. Reabilitação funcional e analgesia com uso de toxina botulínica A na síndrome dolorosa regional complexa tipo I do membro superior: relato de casos. [Functional rehabilitation and analgesia with botulinum toxin A in upper limb complex regional pain syndrome type I: case reports.]. Rev Bras Anestesiol. 2005 Apr;55(2):207-11. doi: 10.1590/s0034-70942005000200007. Portuguese. PMID: 19471824.
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Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology

Bayes M, Rabasseda X, Prous JR.
PMID: 16082427
Methods Find Exp Clin Pharmacol. 2005 May;27(4):265-84.

Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the following tables have been retrieved from the Clinical Trials Knowledge Area of Prous Science Integrity, the drug...

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Bayes M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2005;27(4):265-84
Bayes, M., Rabasseda, X., & Prous, J. R. (2005). Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology, 27(4), 265-84.
Bayes, M, et al. "Gateways to clinical trials." Methods and findings in experimental and clinical pharmacology vol. 27,4 (2005): 265-84.
Bayes M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2005 May;27(4):265-84. PMID: 16082427.
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Parecoxib reduces systemic inflammation and acute lung injury in burned animals with delayed fluid resuscitation.

International journal of inflammation

Chong SJ, Wong YC, Wu J, Tan MH, Lu J, Moochhala SM.
PMID: 24579056
Int J Inflam. 2014;2014:972645. doi: 10.1155/2014/972645. Epub 2014 Jan 21.

Burn injuries result in the release of proinflammatory mediators causing both local and systemic inflammation. Multiple organ dysfunctions secondary to systemic inflammation after severe burn contribute to adverse outcome, with the lungs being the first organ to fail. In...

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Chong SJ, Wong YC, Wu J, et al. Parecoxib reduces systemic inflammation and acute lung injury in burned animals with delayed fluid resuscitation. Int J Inflam. 2014;2014:972645doi: 10.1155/2014/972645.
Chong, S. J., Wong, Y. C., Wu, J., Tan, M. H., Lu, J., & Moochhala, S. M. (2014). Parecoxib reduces systemic inflammation and acute lung injury in burned animals with delayed fluid resuscitation. International journal of inflammation, 2014972645. https://doi.org/10.1155/2014/972645
Chong, Si Jack, et al. "Parecoxib reduces systemic inflammation and acute lung injury in burned animals with delayed fluid resuscitation." International journal of inflammation vol. 2014 (2014): 972645. doi: https://doi.org/10.1155/2014/972645
Chong SJ, Wong YC, Wu J, Tan MH, Lu J, Moochhala SM. Parecoxib reduces systemic inflammation and acute lung injury in burned animals with delayed fluid resuscitation. Int J Inflam. 2014;2014:972645. doi: 10.1155/2014/972645. Epub 2014 Jan 21. PMID: 24579056; PMCID: PMC3918702.
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A randomized controlled trial of preprocedure administration of parecoxib for therapeutic endoscopic retrograde cholangiopancreatography.

Journal of pain research

Amornyotin S, Chalayonnawin W, Kongphlay S.
PMID: 23049274
J Pain Res. 2012;5:251-6. doi: 10.2147/JPR.S33546. Epub 2012 Aug 02.

INTRODUCTION: Parecoxib is occasionally used for analgesia in postprocedural patients. The clinical efficacy of parecoxib used for endoscopic retrograde cholangiopancreatography (ERCP) is controversial. The aim of the study was to determine the clinical efficacy of preprocedure administration of parecoxib...

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Amornyotin S, Chalayonnawin W, Kongphlay S. A randomized controlled trial of preprocedure administration of parecoxib for therapeutic endoscopic retrograde cholangiopancreatography. J Pain Res. 2012;5:251-6doi: 10.2147/JPR.S33546.
Amornyotin, S., Chalayonnawin, W., & Kongphlay, S. (2012). A randomized controlled trial of preprocedure administration of parecoxib for therapeutic endoscopic retrograde cholangiopancreatography. Journal of pain research, 5251-6. https://doi.org/10.2147/JPR.S33546
Amornyotin, Somchai, et al. "A randomized controlled trial of preprocedure administration of parecoxib for therapeutic endoscopic retrograde cholangiopancreatography." Journal of pain research vol. 5 (2012): 251-6. doi: https://doi.org/10.2147/JPR.S33546
Amornyotin S, Chalayonnawin W, Kongphlay S. A randomized controlled trial of preprocedure administration of parecoxib for therapeutic endoscopic retrograde cholangiopancreatography. J Pain Res. 2012;5:251-6. doi: 10.2147/JPR.S33546. Epub 2012 Aug 02. PMID: 23049274; PMCID: PMC3442739.
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A cost-consequence analysis of parecoxib and opioids vs opioids alone for postoperative pain: Chinese perspective.

ClinicoEconomics and outcomes research : CEOR

Barra M, Remák E, Liu DD, Xie L, Abraham L, Sadosky AB.
PMID: 30863130
Clinicoecon Outcomes Res. 2019 Feb 22;11:169-177. doi: 10.2147/CEOR.S183404. eCollection 2019.

PURPOSE: The use of parecoxib plus opioids for postoperative analgesia in noncardiac surgical patients seems to be cost-saving in Europe due to a reduction in opioid use and opioid-related adverse events. Given the lack of information on postoperative analgesic...

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Barra M, Remák E, Liu DD, et al. A cost-consequence analysis of parecoxib and opioids vs opioids alone for postoperative pain: Chinese perspective. Clinicoecon Outcomes Res. 2019;11:169-177doi: 10.2147/CEOR.S183404.
Barra, M., Remák, E., Liu, D. D., Xie, L., Abraham, L., & Sadosky, A. B. (2019). A cost-consequence analysis of parecoxib and opioids vs opioids alone for postoperative pain: Chinese perspective. ClinicoEconomics and outcomes research : CEOR, 11169-177. https://doi.org/10.2147/CEOR.S183404
Barra, Magdolna, et al. "A cost-consequence analysis of parecoxib and opioids vs opioids alone for postoperative pain: Chinese perspective." ClinicoEconomics and outcomes research : CEOR vol. 11 (2019): 169-177. doi: https://doi.org/10.2147/CEOR.S183404
Barra M, Remák E, Liu DD, Xie L, Abraham L, Sadosky AB. A cost-consequence analysis of parecoxib and opioids vs opioids alone for postoperative pain: Chinese perspective. Clinicoecon Outcomes Res. 2019 Feb 22;11:169-177. doi: 10.2147/CEOR.S183404. eCollection 2019. PMID: 30863130; PMCID: PMC6390864.
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Effects of a Single Dose of Parecoxib on Inflammatory Response and Ischemic Tubular Injury Caused by Hemorrhagic Shock in Rats.

Pain research and treatment

Takaku M, da Silva AC, Iritsu NI, Vianna PTG, Castiglia YMM.
PMID: 29535870
Pain Res Treat. 2018 Feb 04;2018:8375746. doi: 10.1155/2018/8375746. eCollection 2018.

Parecoxib, a selective COX-2 inhibitor, is used to improve analgesia in postoperative procedures. Here we evaluated whether pretreatment with a single dose of parecoxib affects the function, cell injury, and inflammatory response of the kidney of rats subjected to...

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Takaku M, da Silva AC, Iritsu NI, et al. Effects of a Single Dose of Parecoxib on Inflammatory Response and Ischemic Tubular Injury Caused by Hemorrhagic Shock in Rats. Pain Res Treat. 2018;2018:8375746doi: 10.1155/2018/8375746.
Takaku, M., da Silva, A. C., Iritsu, N. I., Vianna, P. T. G., & Castiglia, Y. M. M. (2018). Effects of a Single Dose of Parecoxib on Inflammatory Response and Ischemic Tubular Injury Caused by Hemorrhagic Shock in Rats. Pain research and treatment, 20188375746. https://doi.org/10.1155/2018/8375746
Takaku, Mariana, et al. "Effects of a Single Dose of Parecoxib on Inflammatory Response and Ischemic Tubular Injury Caused by Hemorrhagic Shock in Rats." Pain research and treatment vol. 2018 (2018): 8375746. doi: https://doi.org/10.1155/2018/8375746
Takaku M, da Silva AC, Iritsu NI, Vianna PTG, Castiglia YMM. Effects of a Single Dose of Parecoxib on Inflammatory Response and Ischemic Tubular Injury Caused by Hemorrhagic Shock in Rats. Pain Res Treat. 2018 Feb 04;2018:8375746. doi: 10.1155/2018/8375746. eCollection 2018. PMID: 29535870; PMCID: PMC5817310.
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Parecoxib protects against myocardial ischemia/reperfusion via targeting PKA-CREB signaling pathway.

Panminerva medica

Gao J, Zhao G, Wang P, Li S, Wang X, Zhao H.
PMID: 31961110
Panminerva Med. 2020 Jan 20; doi: 10.23736/S0031-0808.19.03775-3. Epub 2020 Jan 20.

No abstract available.

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Gao J, Zhao G, Wang P, et al. Parecoxib protects against myocardial ischemia/reperfusion via targeting PKA-CREB signaling pathway. Panminerva Med. 2020;doi: 10.23736/S0031-0808.19.03775-3.
Gao, J., Zhao, G., Wang, P., Li, S., Wang, X., & Zhao, H. (2020). Parecoxib protects against myocardial ischemia/reperfusion via targeting PKA-CREB signaling pathway. Panminerva medica, . https://doi.org/10.23736/S0031-0808.19.03775-3
Gao, Jiandong, et al. "Parecoxib protects against myocardial ischemia/reperfusion via targeting PKA-CREB signaling pathway." Panminerva medica vol. (2020). doi: https://doi.org/10.23736/S0031-0808.19.03775-3
Gao J, Zhao G, Wang P, Li S, Wang X, Zhao H. Parecoxib protects against myocardial ischemia/reperfusion via targeting PKA-CREB signaling pathway. Panminerva Med. 2020 Jan 20; doi: 10.23736/S0031-0808.19.03775-3. Epub 2020 Jan 20. PMID: 31961110.
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Efficacy of intravenous perioperative parecoxib administration in the surgical fixation of unstable ankle fracture: a prospective, double-blinded, randomized, placebo-controlled trial.

European review for medical and pharmacological sciences

Angthong C, Manuwong S, Singh V, Rajbhandari P, Veljkovic A.
PMID: 34337726
Eur Rev Med Pharmacol Sci. 2021 Jul;25(14):4779-4784. doi: 10.26355/eurrev_202107_26390.

OBJECTIVE: Little is known about the efficacy of perioperative intravenous (IV) non-opioid medication administration in patients undergoing orthopedic surgery. The objective of this study was to determine the efficacy of perioperative parecoxib in patients with unstable ankle fractures who...

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Angthong C, Manuwong S, Singh V, et al. Efficacy of intravenous perioperative parecoxib administration in the surgical fixation of unstable ankle fracture: a prospective, double-blinded, randomized, placebo-controlled trial. Eur Rev Med Pharmacol Sci. 2021;25(14):4779-4784doi: 10.26355/eurrev_202107_26390.
Angthong, C., Manuwong, S., Singh, V., Rajbhandari, P., & Veljkovic, A. (2021). Efficacy of intravenous perioperative parecoxib administration in the surgical fixation of unstable ankle fracture: a prospective, double-blinded, randomized, placebo-controlled trial. European review for medical and pharmacological sciences, 25(14), 4779-4784. https://doi.org/10.26355/eurrev_202107_26390
Angthong, C, et al. "Efficacy of intravenous perioperative parecoxib administration in the surgical fixation of unstable ankle fracture: a prospective, double-blinded, randomized, placebo-controlled trial." European review for medical and pharmacological sciences vol. 25,14 (2021): 4779-4784. doi: https://doi.org/10.26355/eurrev_202107_26390
Angthong C, Manuwong S, Singh V, Rajbhandari P, Veljkovic A. Efficacy of intravenous perioperative parecoxib administration in the surgical fixation of unstable ankle fracture: a prospective, double-blinded, randomized, placebo-controlled trial. Eur Rev Med Pharmacol Sci. 2021 Jul;25(14):4779-4784. doi: 10.26355/eurrev_202107_26390. PMID: 34337726.
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Withdrawn: Parecoxib inhibits inflammatory responses in a mouse model of sepsis.

FEBS open bio

[No authors listed]
PMID: 32243083
FEBS Open Bio. 2022 Jan;12(1):332. doi: 10.1002/2211-5463.12856. Epub 2021 Nov 29.

No abstract available.

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Withdrawn: Parecoxib inhibits inflammatory responses in a mouse model of sepsis. FEBS Open Bio. 2021;12(1):332doi: 10.1002/2211-5463.12856.
(2022). Withdrawn: Parecoxib inhibits inflammatory responses in a mouse model of sepsis. FEBS open bio, 12(1), 332. https://doi.org/10.1002/2211-5463.12856
"Withdrawn: Parecoxib inhibits inflammatory responses in a mouse model of sepsis." FEBS open bio vol. 12,1 (2022): 332. doi: https://doi.org/10.1002/2211-5463.12856
Withdrawn: Parecoxib inhibits inflammatory responses in a mouse model of sepsis. FEBS Open Bio. 2022 Jan;12(1):332. doi: 10.1002/2211-5463.12856. Epub 2021 Nov 29. PMID: 32243083.
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Showing 1 to 12 of 97 entries