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Showing 1 to 11 of 11 entries
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Designer Benzodiazepines: A Review of Toxicology and Public Health Risks.

Pharmaceuticals (Basel, Switzerland)

Brunetti P, Giorgetti R, Tagliabracci A, Huestis MA, Busardò FP.
PMID: 34208284
Pharmaceuticals (Basel). 2021 Jun 11;14(6). doi: 10.3390/ph14060560.

The rising use of designer benzodiazepines (DBZD) is a cat-and-mouse game between organized crime and law enforcement. Non-prohibited benzodiazepines are introduced onto the global drug market and scheduled as rapidly as possible by international authorities. In response, DBZD are...

β-Polymorph of phenazepam: a powder study.

Acta crystallographica. Section E, Structure reports online

Sergeev GB, Sergeev BM, Morosov YN, Chernyshev VV.
PMID: 21587597
Acta Crystallogr Sect E Struct Rep Online. 2010 Sep 25;66:o2623. doi: 10.1107/S1600536810037402.

THE TITLE COMPOUND [SYSTEMATIC NAME: 7-bromo-5-(2-chloro-phen-yl)-1H-1,4-benzodiazepin-2(3H)-one] (β-polymorph), C(15)H(10)BrClN(2)O, has been obtained via cryomodification of the known α-polymorph of phenazepam [Karapetyan et al. (1979 ▶). Bioorg. Khim.5, 1684-1690]. In both polymorphs, the mol-ecules, which differ only in the dihedral angles...

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.

Frontiers in pharmacology

Volkova A, Shadrina M, Kolomin T, Andreeva L, Limborska S, Myasoedov N, Slominsky P.
PMID: 26924987
Front Pharmacol. 2016 Feb 18;7:31. doi: 10.3389/fphar.2016.00031. eCollection 2016.

Clinical studies have shown the similarity of the spectrum of physiological effects of Selank and classical benzodiazepines, such as diazepam and phenazepam. These data suggest that there is a similar basis of their mechanism of action. To test this...

An update on the anxiolytic and neuroprotective properties of etifoxine: from brain GABA modulation to a whole-body mode of action.

Neuropsychiatric disease and treatment

Nuss P, Ferreri F, Bourin M.
PMID: 31308671
Neuropsychiatr Dis Treat. 2019 Jul 03;15:1781-1795. doi: 10.2147/NDT.S200568. eCollection 2019.

Treating the signs and symptoms of anxiety is an everyday challenge in clinical practice. When choosing between treatment options, anxiety needs to be understood in the situational, psychiatric, and biological context in which it arises. Etifoxine, a non-benzodiazepine anxiolytic...

Influence of Plasma Concentration of Hsa-Mir-370-3p and Cyp2d6*4 On Equilibrium Concentration of Phenazepam in Patients with Recurrent Depressive Disorder.

Psychopharmacology bulletin

Zastrozhin MS, Efimova AV, Skryabin V, Smirnov VV, Petukhov AE, Pankratenko EP, Pozdniakov SA, Kaverina EV, Klepikov DA, Grishina EA, Ryzhikova KA, Bure IV, Bryun EA, Sychev DA.
PMID: 34887601
Psychopharmacol Bull. 2021 Nov 03;51(4):87-104.

INTRODUCTION: Phenazepam is commonly administered to patients diagnosed with major depressive disorder. Some proportion of such patients do not show adequate response to treatment regimen containing phenazepam, whereas many of them experience type A adverse drug reactions. Previous studies...

Influence of Plasma Concentration of Hsa-Mir-370-3p and Cyp2d6*4 On Equilibrium Concentration of Phenazepam in Patients with Recurrent Depressive Disorder.

Psychopharmacology bulletin

Zastrozhin MS, Efimova AV, Skryabin V, Smirnov VV, Petukhov AE, Pankratenko EP, Pozdniakov SA, Kaverina EV, Klepikov DA, Grishina EA, Ryzhikova KA, Bure IV, Bryun EA, Sychev DA.
PMID: 34887601
Psychopharmacol Bull. 2021 Nov 03;51(4):87-104.

INTRODUCTION: Phenazepam is commonly administered to patients diagnosed with major depressive disorder. Some proportion of such patients do not show adequate response to treatment regimen containing phenazepam, whereas many of them experience type A adverse drug reactions. Previous studies...

Adaptation of Piglets Using Different Methods of Stress Prevention.

Animals : an open access journal from MDPI

Bekenev V, Garcia A, Hasnulin V.
PMID: 26479239
Animals (Basel). 2015 May 13;5(2):349-60. doi: 10.3390/ani5020349.

The purpose of this study was to evaluate the viability and growth rate of piglets after weaning, the content of lipids in the blood and liver, antioxidant activity (AOA) and lipid peroxidation (LPO) when various additives are used in...

Evidence of Designer Benzodiazepine Use in Routine Healthcare Urine Drug Specimens.

Journal of addiction medicine

Garland JM, Hull JD, Bender CL, Marshall L, Holt AC.
PMID: 34172626
J Addict Med. 2021 Jun 23; doi: 10.1097/ADM.0000000000000884. Epub 2021 Jun 23.

OBJECTIVES: The illicit drug market continuously evolves, with new substances introduced to mimic prescription or other illicit drugs while evading detection by routine drug testing. The objective was to determine if designer benzodiazepines would be present in urine samples...

New uncontrolled benzodiazepine, phenazepam, emerging drug of abuse.

Innovations in clinical neuroscience

Oyemade A.
PMID: 23074694
Innov Clin Neurosci. 2012 Sep;9(9):10.

No abstract available.

Formation of Synthetically Versatile 2-Aminobenzophenones from Readily Accessed Acyl Hydrazides.

ACS omega

Ahmed N, Shamsabadi A, Chudasama V.
PMID: 31909344
ACS Omega. 2019 Dec 17;4(27):22601-22612. doi: 10.1021/acsomega.9b03417. eCollection 2019 Dec 31.

Herein, we report the transformation of readily accessed acyl hydrazides into protected 2-aminobenzophenones via a two-step process involving an aryne-based molecular rearrangement followed by a one-pot addition-elimination procedure. The assembly of the scaffold is tolerant of a wide variety...

Determination of Cross-Reactivity of Novel Psychoactive Substances with Drug Screen Immunoassays Kits in Whole Blood.

Journal of analytical toxicology

Mastrovito R, Trail C, Lino M, Cervantes A, Chan-Hosokawa A, Strathmann F, Logan B.
PMID: 34791285
J Anal Toxicol. 2021 Nov 16; doi: 10.1093/jat/bkab110. Epub 2021 Nov 16.

The purpose of this study was to examine the impact of 59 novel psychoactive compounds on common enzyme-linked immunosorbent assay (ELISA) testing kits. Concentrations above and below the individual kit reporting limits in each class were measured. Compounds that...

Showing 1 to 11 of 11 entries