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Multifaceted Mechanisms of WY-14643 to Stabilize the Blood-Brain Barrier in a Model of Traumatic Brain Injury.

Frontiers in molecular neuroscience

Neuhaus W, Krämer T, Neuhoff A, Gölz C, Thal SC, Förster CY.
PMID: 28603485
Front Mol Neurosci. 2017 May 26;10:149. doi: 10.3389/fnmol.2017.00149. eCollection 2017.

The blood-brain barrier (BBB) is damaged during ischemic insults such as traumatic brain injury or stroke. This contributes to vasogenic edema formation and deteriorate disease outcomes. Enormous efforts are pursued to understand underlying mechanisms of ischemic insults and develop...

The Effect of Unsaturated Fatty Acids on Molecular Markers of Cholesterol Homeostasis in THP-1 Macrophages.

Iranian Red Crescent medical journal

Zavar Reza J, Nahangi H, Mansouri R, Dehghani A, Mojarrad M, Fathi M, Nikzamir A, Yekaninejad MS.
PMID: 24396573
Iran Red Crescent Med J. 2013 Jul;15(7):554-9. doi: 10.5812/ircmj.11780. Epub 2013 Jul 05.

BACKGROUND: Macrophages derived foam cells are key factors in the maladaptive immune and inflammatory response.OBJECTIVES: The study of the cholesterol homeostasis and the molecular factor involved in these cells is very important in understanding the process of atherosclerosis and...

Comparison of Glaucoma-Relevant Transcriptomic Datasets Identifies Novel Drug Targets for Retinal Ganglion Cell Neuroprotection.

Journal of clinical medicine

Enz TJ, Tribble JR, Williams PA.
PMID: 34501387
J Clin Med. 2021 Aug 31;10(17). doi: 10.3390/jcm10173938.

Glaucoma is a leading cause of blindness and is characterized by the progressive dysfunction and irreversible death of retinal ganglion cells. We aimed to identify shared differentially expressed genes (DE genes) between different glaucoma relevant models of retinal ganglion...

Showing 1 to 3 of 3 entries