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Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins.

Computational and structural biotechnology journal

Wang Y, Ji D, Lei C, Chen Y, Qiu Y, Li X, Li M, Ni D, Pu J, Zhang J, Fu Q, Liu Y, Lu S.
PMID: 33680360
Comput Struct Biotechnol J. 2021 Feb 09;19:1184-1199. doi: 10.1016/j.csbj.2021.01.044. eCollection 2021.

Ras undergoes interconversion between the active GTP-bound state and the inactive GDP-bound state. This GTPase cycle, which controls the activities of Ras, is accelerated by Ras GTPase-activating proteins (GAPs) and guanine nucleotide exchange factors (SOS). Oncogenic Ras mutations could...

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Wang Y, Ji D, Lei C, et al. Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins. Comput Struct Biotechnol J. 2021;19:1184-1199doi: 10.1016/j.csbj.2021.01.044.
Wang, Y., Ji, D., Lei, C., Chen, Y., Qiu, Y., Li, X., Li, M., Ni, D., Pu, J., Zhang, J., Fu, Q., Liu, Y., & Lu, S. (2021). Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins. Computational and structural biotechnology journal, 191184-1199. https://doi.org/10.1016/j.csbj.2021.01.044
Wang, Yuanhao, et al. "Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins." Computational and structural biotechnology journal vol. 19 (2021): 1184-1199. doi: https://doi.org/10.1016/j.csbj.2021.01.044
Wang Y, Ji D, Lei C, Chen Y, Qiu Y, Li X, Li M, Ni D, Pu J, Zhang J, Fu Q, Liu Y, Lu S. Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins. Comput Struct Biotechnol J. 2021 Feb 09;19:1184-1199. doi: 10.1016/j.csbj.2021.01.044. eCollection 2021. PMID: 33680360; PMCID: PMC7902900.
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RASAL3 Is a Putative RasGAP Modulating Inflammatory Response by Neutrophils.

Frontiers in immunology

Saito S, Cao DY, Victor AR, Peng Z, Wu HY, Okwan-Duodu D.
PMID: 34777356
Front Immunol. 2021 Oct 27;12:744300. doi: 10.3389/fimmu.2021.744300. eCollection 2021.

As first responder cells in host defense, neutrophils must be carefully regulated to prevent collateral tissue injury. However, the intracellular events that titrate the neutrophil's response to inflammatory stimuli remain poorly understood. As a molecular switch, Ras activity is...

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Saito S, Cao DY, Victor AR, et al. RASAL3 Is a Putative RasGAP Modulating Inflammatory Response by Neutrophils. Front Immunol. 2021;12:744300doi: 10.3389/fimmu.2021.744300.
Saito, S., Cao, D. Y., Victor, A. R., Peng, Z., Wu, H. Y., & Okwan-Duodu, D. (2021). RASAL3 Is a Putative RasGAP Modulating Inflammatory Response by Neutrophils. Frontiers in immunology, 12744300. https://doi.org/10.3389/fimmu.2021.744300
Saito, Suguru, et al. "RASAL3 Is a Putative RasGAP Modulating Inflammatory Response by Neutrophils." Frontiers in immunology vol. 12 (2021): 744300. doi: https://doi.org/10.3389/fimmu.2021.744300
Saito S, Cao DY, Victor AR, Peng Z, Wu HY, Okwan-Duodu D. RASAL3 Is a Putative RasGAP Modulating Inflammatory Response by Neutrophils. Front Immunol. 2021 Oct 27;12:744300. doi: 10.3389/fimmu.2021.744300. eCollection 2021. PMID: 34777356; PMCID: PMC8579101.
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Pathogenetics of the RASopathies.

Human molecular genetics

Tidyman WE, Rauen KA.
PMID: 27412009
Hum Mol Genet. 2016 Oct 01;25:R123-R132. doi: 10.1093/hmg/ddw191. Epub 2016 Jul 12.

The RASopathies are defined as a group of medical genetics syndromes that are caused by germ-line mutations in genes that encode components or regulators of the Ras/mitogen-activated protein kinase (MAPK) pathway. Taken together, the RASopathies represent one of the...

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Tidyman WE, Rauen KA. Pathogenetics of the RASopathies. Hum Mol Genet. 2016;25:R123-R132doi: 10.1093/hmg/ddw191.
Tidyman, W. E., & Rauen, K. A. (2016). Pathogenetics of the RASopathies. Human molecular genetics, 25R123-R132. https://doi.org/10.1093/hmg/ddw191
Tidyman, William E, and Rauen, Katherine A. "Pathogenetics of the RASopathies." Human molecular genetics vol. 25 (2016): R123-R132. doi: https://doi.org/10.1093/hmg/ddw191
Tidyman WE, Rauen KA. Pathogenetics of the RASopathies. Hum Mol Genet. 2016 Oct 01;25:R123-R132. doi: 10.1093/hmg/ddw191. Epub 2016 Jul 12. PMID: 27412009; PMCID: PMC6283265.
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Concepts in Ras-directed therapy.

Expert opinion on investigational drugs

Kloog Y, Cox AD, Sinensky M.
PMID: 11139843
Expert Opin Investig Drugs. 1999 Dec;8(12):2121-2140. doi: 10.1517/13543784.8.12.2121.

Ras proteins are key transducers of growth signals regulated by cell surface receptors. They are anchored to the inner surface of the cell membrane where receptor-mediated signalling induces Ras activation (GDP/GTP exchange) and inactivation (stimulation of Ras GTPase activity)....

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Kloog Y, Cox AD, Sinensky M. Concepts in Ras-directed therapy. Expert Opin Investig Drugs. 1999;8(12):2121-2140doi: 10.1517/13543784.8.12.2121.
Kloog, Y., Cox, A. D., & Sinensky, M. (1999). Concepts in Ras-directed therapy. Expert opinion on investigational drugs, 8(12), 2121-2140. https://doi.org/10.1517/13543784.8.12.2121
Kloog, et al. "Concepts in Ras-directed therapy." Expert opinion on investigational drugs vol. 8,12 (1999): 2121-2140. doi: https://doi.org/10.1517/13543784.8.12.2121
Kloog Y, Cox AD, Sinensky M. Concepts in Ras-directed therapy. Expert Opin Investig Drugs. 1999 Dec;8(12):2121-2140. doi: 10.1517/13543784.8.12.2121. PMID: 11139843.
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Showing 1 to 4 of 4 entries