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Showing 1 to 11 of 11 entries
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Research progress on signaling pathways in cirrhotic portal hypertension.

World journal of clinical cases

Xu W, Liu P, Mu YP.
PMID: 30283796
World J Clin Cases. 2018 Sep 26;6(10):335-343. doi: 10.12998/wjcc.v6.i10.335.

Portal hypertension (PHT) is an important consequence of liver cirrhosis, which can lead to complications that adversely affect a patient's quality of life and survival, such as upper gastrointestinal bleeding, ascites, and portosystemic encephalopathy. In recent years, advances in...

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Xu W, Liu P, Mu YP. Research progress on signaling pathways in cirrhotic portal hypertension. World J Clin Cases. 2018;6(10):335-343doi: 10.12998/wjcc.v6.i10.335.
Xu, W., Liu, P., & Mu, Y. P. (2018). Research progress on signaling pathways in cirrhotic portal hypertension. World journal of clinical cases, 6(10), 335-343. https://doi.org/10.12998/wjcc.v6.i10.335
Xu, Wen, et al. "Research progress on signaling pathways in cirrhotic portal hypertension." World journal of clinical cases vol. 6,10 (2018): 335-343. doi: https://doi.org/10.12998/wjcc.v6.i10.335
Xu W, Liu P, Mu YP. Research progress on signaling pathways in cirrhotic portal hypertension. World J Clin Cases. 2018 Sep 26;6(10):335-343. doi: 10.12998/wjcc.v6.i10.335. PMID: 30283796; PMCID: PMC6163134.
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RhoA/ROCK-1 Signaling Pathway and Oxidative Stress in Coronary Artery Disease Patients.

Brazilian journal of cardiovascular surgery

Dokumacioglu E, Duzcan I, Iskender H, Sahin A.
PMID: 34236817
Braz J Cardiovasc Surg. 2021 Jul 07; doi: 10.21470/1678-9741-2020-0525. Epub 2021 Jul 07.

INTRODUCTION: Coronary artery disease (CAD) is an ischemic condition that occurs as a result of partial or complete interruption of blood flow by narrowing or complete blockage of the vessels supplying the heart, which are called coronary arteries. Our...

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Dokumacioglu E, Duzcan I, Iskender H, et al. RhoA/ROCK-1 Signaling Pathway and Oxidative Stress in Coronary Artery Disease Patients. Braz J Cardiovasc Surg. 2021;doi: 10.21470/1678-9741-2020-0525.
Dokumacioglu, E., Duzcan, I., Iskender, H., & Sahin, A. (2021). RhoA/ROCK-1 Signaling Pathway and Oxidative Stress in Coronary Artery Disease Patients. Brazilian journal of cardiovascular surgery, . https://doi.org/10.21470/1678-9741-2020-0525
Dokumacioglu, Eda, et al. "RhoA/ROCK-1 Signaling Pathway and Oxidative Stress in Coronary Artery Disease Patients." Brazilian journal of cardiovascular surgery vol. (2021). doi: https://doi.org/10.21470/1678-9741-2020-0525
Dokumacioglu E, Duzcan I, Iskender H, Sahin A. RhoA/ROCK-1 Signaling Pathway and Oxidative Stress in Coronary Artery Disease Patients. Braz J Cardiovasc Surg. 2021 Jul 07; doi: 10.21470/1678-9741-2020-0525. Epub 2021 Jul 07. PMID: 34236817.
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Inhibition of Rho-Associated Kinase Suppresses Medulloblastoma Growth.

Cancers

Dyberg C, Andonova T, Olsen TK, Brodin B, Kool M, Kogner P, Johnsen JI, Wickström M.
PMID: 31888022
Cancers (Basel). 2019 Dec 26;12(1). doi: 10.3390/cancers12010073.

Medulloblastoma is one of the most common malignant brain tumor types in children, with an overall survival of 70%. Mortality is associated with metastatic relapsed tumors. Rho-associated kinases (ROCKs), important for epithelial-mesenchymal transition (EMT) and proper nervous system development,...

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Dyberg C, Andonova T, Olsen TK, et al. Inhibition of Rho-Associated Kinase Suppresses Medulloblastoma Growth. Cancers (Basel). 2019;12(1)doi: 10.3390/cancers12010073.
Dyberg, C., Andonova, T., Olsen, T. K., Brodin, B., Kool, M., Kogner, P., Johnsen, J. I., & Wickström, M. (2019). Inhibition of Rho-Associated Kinase Suppresses Medulloblastoma Growth. Cancers, 12(1), . https://doi.org/10.3390/cancers12010073
Dyberg, Cecilia, et al. "Inhibition of Rho-Associated Kinase Suppresses Medulloblastoma Growth." Cancers vol. 12,1 (2019). doi: https://doi.org/10.3390/cancers12010073
Dyberg C, Andonova T, Olsen TK, Brodin B, Kool M, Kogner P, Johnsen JI, Wickström M. Inhibition of Rho-Associated Kinase Suppresses Medulloblastoma Growth. Cancers (Basel). 2019 Dec 26;12(1). doi: 10.3390/cancers12010073. PMID: 31888022; PMCID: PMC7016943.
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Injectable Immunotherapeutic Thermogel for Enhanced Immunotherapy Post Tumor Radiofrequency Ablation.

Small (Weinheim an der Bergstrasse, Germany)

Chen M, Tan Y, Hu J, Jiang Y, Wang Z, Liu Z, Chen Q.
PMID: 34729889
Small. 2021 Dec;17(52):e2104773. doi: 10.1002/smll.202104773. Epub 2021 Nov 02.

Tumor radiofrequency ablation (RFA) is a local and minimally invasive application using high temperature to induce coagulative necrosis of tumor, which has been commonly used in clinic. Although the tumor fragments generated by RFA can activate the host's immune...

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Chen M, Tan Y, Hu J, et al. Injectable Immunotherapeutic Thermogel for Enhanced Immunotherapy Post Tumor Radiofrequency Ablation. Small. 2021;17(52):e2104773doi: 10.1002/smll.202104773.
Chen, M., Tan, Y., Hu, J., Jiang, Y., Wang, Z., Liu, Z., & Chen, Q. (2021). Injectable Immunotherapeutic Thermogel for Enhanced Immunotherapy Post Tumor Radiofrequency Ablation. Small (Weinheim an der Bergstrasse, Germany), 17(52), e2104773. https://doi.org/10.1002/smll.202104773
Chen, Muchao, et al. "Injectable Immunotherapeutic Thermogel for Enhanced Immunotherapy Post Tumor Radiofrequency Ablation." Small (Weinheim an der Bergstrasse, Germany) vol. 17,52 (2021): e2104773. doi: https://doi.org/10.1002/smll.202104773
Chen M, Tan Y, Hu J, Jiang Y, Wang Z, Liu Z, Chen Q. Injectable Immunotherapeutic Thermogel for Enhanced Immunotherapy Post Tumor Radiofrequency Ablation. Small. 2021 Dec;17(52):e2104773. doi: 10.1002/smll.202104773. Epub 2021 Nov 02. PMID: 34729889.
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The Design, Synthesis and Evaluation of Rho-kinase Inhibitory Activity of 4-aryl-thiazole-2-amines.

Iranian journal of pharmaceutical research : IJPR

Wang L, Ouyang B, Fan M, Qi J, Yao L.
PMID: 34903975
Iran J Pharm Res. 2021;20(3):121-131. doi: 10.22037/ijpr.2020.114468.14866.

Rho-associated kinases (ROCK) are a class of serine/threonine kinases that play important roles in various biological processes. ROCK are becoming attractive targets for drug designing. A novel scaffold was designed according to molecular hybridization strategy, then a series of...

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Wang L, Ouyang B, Fan M, et al. The Design, Synthesis and Evaluation of Rho-kinase Inhibitory Activity of 4-aryl-thiazole-2-amines. Iran J Pharm Res. 2021;20(3):121-131doi: 10.22037/ijpr.2020.114468.14866.
Wang, L., Ouyang, B., Fan, M., Qi, J., & Yao, L. (2021). The Design, Synthesis and Evaluation of Rho-kinase Inhibitory Activity of 4-aryl-thiazole-2-amines. Iranian journal of pharmaceutical research : IJPR, 20(3), 121-131. https://doi.org/10.22037/ijpr.2020.114468.14866
Wang, Linan, et al. "The Design, Synthesis and Evaluation of Rho-kinase Inhibitory Activity of 4-aryl-thiazole-2-amines." Iranian journal of pharmaceutical research : IJPR vol. 20,3 (2021): 121-131. doi: https://doi.org/10.22037/ijpr.2020.114468.14866
Wang L, Ouyang B, Fan M, Qi J, Yao L. The Design, Synthesis and Evaluation of Rho-kinase Inhibitory Activity of 4-aryl-thiazole-2-amines. Iran J Pharm Res. 2021;20(3):121-131. doi: 10.22037/ijpr.2020.114468.14866. PMID: 34903975; PMCID: PMC8653655.
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Rho-associated kinases contribute to the regulation of tau phosphorylation and amyloid metabolism during neuronal plasticity.

Pharmacological reports : PR

Saray H, Süer C, Koşar B, Tan B, Dursun N.
PMID: 34060063
Pharmacol Rep. 2021 Oct;73(5):1303-1314. doi: 10.1007/s43440-021-00279-3. Epub 2021 Jun 01.

BACKGROUND: Neural plasticity under physiological condition develops together with normal tau phosphorylation and amyloid precursor protein (APP) processing. Since restoration of PI3-kinase signaling has therapeutic potential in Alzheimer's disease, we investigated plasticity-related changes in tau and APP metabolism by...

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Saray H, Süer C, Koşar B, et al. Rho-associated kinases contribute to the regulation of tau phosphorylation and amyloid metabolism during neuronal plasticity. Pharmacol Rep. 2021;73(5):1303-1314doi: 10.1007/s43440-021-00279-3.
Saray, H., Süer, C., Koşar, B., Tan, B., & Dursun, N. (2021). Rho-associated kinases contribute to the regulation of tau phosphorylation and amyloid metabolism during neuronal plasticity. Pharmacological reports : PR, 73(5), 1303-1314. https://doi.org/10.1007/s43440-021-00279-3
Saray, Hatice, et al. "Rho-associated kinases contribute to the regulation of tau phosphorylation and amyloid metabolism during neuronal plasticity." Pharmacological reports : PR vol. 73,5 (2021): 1303-1314. doi: https://doi.org/10.1007/s43440-021-00279-3
Saray H, Süer C, Koşar B, Tan B, Dursun N. Rho-associated kinases contribute to the regulation of tau phosphorylation and amyloid metabolism during neuronal plasticity. Pharmacol Rep. 2021 Oct;73(5):1303-1314. doi: 10.1007/s43440-021-00279-3. Epub 2021 Jun 01. PMID: 34060063.
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Status of Rho kinase inhibitors in glaucoma therapeutics-an overview.

International ophthalmology

Saha BC, Kumari R, Kushumesh R, Ambasta A, Sinha BP.
PMID: 34453229
Int Ophthalmol. 2021 Aug 27; doi: 10.1007/s10792-021-02002-w. Epub 2021 Aug 27.

Medical management remains the cornerstone of glaucoma management despite advances in the surgical or laser procedures. After a leap of almost two decades of the advent of prostaglandin analogues, recently a new class of drug, Rho kinase (ROCK) inhibitors,...

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Saha BC, Kumari R, Kushumesh R, et al. Status of Rho kinase inhibitors in glaucoma therapeutics-an overview. Int Ophthalmol. 2021;doi: 10.1007/s10792-021-02002-w.
Saha, B. C., Kumari, R., Kushumesh, R., Ambasta, A., & Sinha, B. P. (2021). Status of Rho kinase inhibitors in glaucoma therapeutics-an overview. International ophthalmology, . https://doi.org/10.1007/s10792-021-02002-w
Saha, Bhawesh Chandra, et al. "Status of Rho kinase inhibitors in glaucoma therapeutics-an overview." International ophthalmology vol. (2021). doi: https://doi.org/10.1007/s10792-021-02002-w
Saha BC, Kumari R, Kushumesh R, Ambasta A, Sinha BP. Status of Rho kinase inhibitors in glaucoma therapeutics-an overview. Int Ophthalmol. 2021 Aug 27; doi: 10.1007/s10792-021-02002-w. Epub 2021 Aug 27. PMID: 34453229.
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The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease.

Frontiers in pharmacology

Hartmann S, Ridley AJ, Lutz S.
PMID: 26635606
Front Pharmacol. 2015 Nov 20;6:276. doi: 10.3389/fphar.2015.00276. eCollection 2015.

Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in diverse cellular activities including actin cytoskeleton organization, cell adhesion and motility, proliferation and apoptosis, remodeling...

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Hartmann S, Ridley AJ, Lutz S. The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease. Front Pharmacol. 2015;6:276doi: 10.3389/fphar.2015.00276.
Hartmann, S., Ridley, A. J., & Lutz, S. (2015). The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease. Frontiers in pharmacology, 6276. https://doi.org/10.3389/fphar.2015.00276
Hartmann, Svenja, et al. "The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease." Frontiers in pharmacology vol. 6 (2015): 276. doi: https://doi.org/10.3389/fphar.2015.00276
Hartmann S, Ridley AJ, Lutz S. The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease. Front Pharmacol. 2015 Nov 20;6:276. doi: 10.3389/fphar.2015.00276. eCollection 2015. PMID: 26635606; PMCID: PMC4653301.
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Injectable Immunotherapeutic Thermogel for Enhanced Immunotherapy Post Tumor Radiofrequency Ablation.

Small (Weinheim an der Bergstrasse, Germany)

Chen M, Tan Y, Hu J, Jiang Y, Wang Z, Liu Z, Chen Q.
PMID: 34729889
Small. 2021 Nov 02;e2104773. doi: 10.1002/smll.202104773. Epub 2021 Nov 02.

Tumor radiofrequency ablation (RFA) is a local and minimally invasive application using high temperature to induce coagulative necrosis of tumor, which has been commonly used in clinic. Although the tumor fragments generated by RFA can activate the host's immune...

Cite
Chen M, Tan Y, Hu J, et al. Injectable Immunotherapeutic Thermogel for Enhanced Immunotherapy Post Tumor Radiofrequency Ablation. Small. 2021;e2104773doi: 10.1002/smll.202104773.
Chen, M., Tan, Y., Hu, J., Jiang, Y., Wang, Z., Liu, Z., & Chen, Q. (2021). Injectable Immunotherapeutic Thermogel for Enhanced Immunotherapy Post Tumor Radiofrequency Ablation. Small (Weinheim an der Bergstrasse, Germany), e2104773. https://doi.org/10.1002/smll.202104773
Chen, Muchao, et al. "Injectable Immunotherapeutic Thermogel for Enhanced Immunotherapy Post Tumor Radiofrequency Ablation." Small (Weinheim an der Bergstrasse, Germany) vol. (2021): e2104773. doi: https://doi.org/10.1002/smll.202104773
Chen M, Tan Y, Hu J, Jiang Y, Wang Z, Liu Z, Chen Q. Injectable Immunotherapeutic Thermogel for Enhanced Immunotherapy Post Tumor Radiofrequency Ablation. Small. 2021 Nov 02;e2104773. doi: 10.1002/smll.202104773. Epub 2021 Nov 02. PMID: 34729889.
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Injectable Immunotherapeutic Thermogel for Enhanced Immunotherapy Post Tumor Radiofrequency Ablation.

Small (Weinheim an der Bergstrasse, Germany)

Chen M, Tan Y, Hu J, Jiang Y, Wang Z, Liu Z, Chen Q.
PMID: 34729889
Small. 2021 Dec;17(52):e2104773. doi: 10.1002/smll.202104773. Epub 2021 Nov 02.

Tumor radiofrequency ablation (RFA) is a local and minimally invasive application using high temperature to induce coagulative necrosis of tumor, which has been commonly used in clinic. Although the tumor fragments generated by RFA can activate the host's immune...

Cite
Chen M, Tan Y, Hu J, et al. Injectable Immunotherapeutic Thermogel for Enhanced Immunotherapy Post Tumor Radiofrequency Ablation. Small. 2021;17(52):e2104773doi: 10.1002/smll.202104773.
Chen, M., Tan, Y., Hu, J., Jiang, Y., Wang, Z., Liu, Z., & Chen, Q. (2021). Injectable Immunotherapeutic Thermogel for Enhanced Immunotherapy Post Tumor Radiofrequency Ablation. Small (Weinheim an der Bergstrasse, Germany), 17(52), e2104773. https://doi.org/10.1002/smll.202104773
Chen, Muchao, et al. "Injectable Immunotherapeutic Thermogel for Enhanced Immunotherapy Post Tumor Radiofrequency Ablation." Small (Weinheim an der Bergstrasse, Germany) vol. 17,52 (2021): e2104773. doi: https://doi.org/10.1002/smll.202104773
Chen M, Tan Y, Hu J, Jiang Y, Wang Z, Liu Z, Chen Q. Injectable Immunotherapeutic Thermogel for Enhanced Immunotherapy Post Tumor Radiofrequency Ablation. Small. 2021 Dec;17(52):e2104773. doi: 10.1002/smll.202104773. Epub 2021 Nov 02. PMID: 34729889.
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The Design, Synthesis and Evaluation of Rho-kinase Inhibitory Activity of 4-aryl-thiazole-2-amines.

Iranian journal of pharmaceutical research : IJPR

Wang L, Ouyang B, Fan M, Qi J, Yao L.
PMID: 34903975
Iran J Pharm Res. 2021;20(3):121-131. doi: 10.22037/ijpr.2020.114468.14866.

Rho-associated kinases (ROCK) are a class of serine/threonine kinases that play important roles in various biological processes. ROCK are becoming attractive targets for drug designing. A novel scaffold was designed according to molecular hybridization strategy, then a series of...

Cite
Wang L, Ouyang B, Fan M, et al. The Design, Synthesis and Evaluation of Rho-kinase Inhibitory Activity of 4-aryl-thiazole-2-amines. Iran J Pharm Res. 2021;20(3):121-131doi: 10.22037/ijpr.2020.114468.14866.
Wang, L., Ouyang, B., Fan, M., Qi, J., & Yao, L. (2021). The Design, Synthesis and Evaluation of Rho-kinase Inhibitory Activity of 4-aryl-thiazole-2-amines. Iranian journal of pharmaceutical research : IJPR, 20(3), 121-131. https://doi.org/10.22037/ijpr.2020.114468.14866
Wang, Linan, et al. "The Design, Synthesis and Evaluation of Rho-kinase Inhibitory Activity of 4-aryl-thiazole-2-amines." Iranian journal of pharmaceutical research : IJPR vol. 20,3 (2021): 121-131. doi: https://doi.org/10.22037/ijpr.2020.114468.14866
Wang L, Ouyang B, Fan M, Qi J, Yao L. The Design, Synthesis and Evaluation of Rho-kinase Inhibitory Activity of 4-aryl-thiazole-2-amines. Iran J Pharm Res. 2021;20(3):121-131. doi: 10.22037/ijpr.2020.114468.14866. PMID: 34903975; PMCID: PMC8653655.
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Showing 1 to 11 of 11 entries