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Suxiao jiuxin pill induces potent relaxation and inhibition on contraction in human artery and the mechanism.

Evidence-based complementary and alternative medicine : eCAM

Bai XY, Zhang P, Yang Q, Liu XC, Wang J, Tong YL, Xiong SJ, Liu LH, Wang L, He GW.
PMID: 24808920
Evid Based Complement Alternat Med. 2014;2014:956924. doi: 10.1155/2014/956924. Epub 2014 Apr 07.

Suxiao Jiuxin Pill, a compound Chinese traditional medicine with main components of tetramethylpyrazine and borneol, is widely used for antiangina treatment in China but its pharmacological effect on human blood vessels is unknown. We investigated the effect and possible...

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Bai XY, Zhang P, Yang Q, et al. Suxiao jiuxin pill induces potent relaxation and inhibition on contraction in human artery and the mechanism. Evid Based Complement Alternat Med. 2014;2014:956924doi: 10.1155/2014/956924.
Bai, X. Y., Zhang, P., Yang, Q., Liu, X. C., Wang, J., Tong, Y. L., Xiong, S. J., Liu, L. H., Wang, L., & He, G. W. (2014). Suxiao jiuxin pill induces potent relaxation and inhibition on contraction in human artery and the mechanism. Evidence-based complementary and alternative medicine : eCAM, 2014956924. https://doi.org/10.1155/2014/956924
Bai, Xiao-Yan, et al. "Suxiao jiuxin pill induces potent relaxation and inhibition on contraction in human artery and the mechanism." Evidence-based complementary and alternative medicine : eCAM vol. 2014 (2014): 956924. doi: https://doi.org/10.1155/2014/956924
Bai XY, Zhang P, Yang Q, Liu XC, Wang J, Tong YL, Xiong SJ, Liu LH, Wang L, He GW. Suxiao jiuxin pill induces potent relaxation and inhibition on contraction in human artery and the mechanism. Evid Based Complement Alternat Med. 2014;2014:956924. doi: 10.1155/2014/956924. Epub 2014 Apr 07. PMID: 24808920; PMCID: PMC3997901.
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Tetramethylpyrazine inhibits CTGF and Smad2/3 expression and proliferation of hepatic stellate cells.

Biotechnology, biotechnological equipment

Li J, Dong N, Cheng S, Li X, Wang W, Xiang Y.
PMID: 26019625
Biotechnol Biotechnol Equip. 2015 Jan 02;29(1):124-131. doi: 10.1080/13102818.2014.984382. Epub 2015 Jan 28.

To study the effects of tetramethylpyrazine (TMP) on the proliferation of hepatic stellate cells-T6 (HSC-T6), and the expression of connective tissue growth factor (CTGF) and Smad2/3 in these cells, HSC-T6 cells were cultured with TMP at different concentrations after...

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Li J, Dong N, Cheng S, et al. Tetramethylpyrazine inhibits CTGF and Smad2/3 expression and proliferation of hepatic stellate cells. Biotechnol Biotechnol Equip. 2015;29(1):124-131doi: 10.1080/13102818.2014.984382.
Li, J., Dong, N., Cheng, S., Li, X., Wang, W., & Xiang, Y. (2015). Tetramethylpyrazine inhibits CTGF and Smad2/3 expression and proliferation of hepatic stellate cells. Biotechnology, biotechnological equipment, 29(1), 124-131. https://doi.org/10.1080/13102818.2014.984382
Li, Jun, et al. "Tetramethylpyrazine inhibits CTGF and Smad2/3 expression and proliferation of hepatic stellate cells." Biotechnology, biotechnological equipment vol. 29,1 (2015): 124-131. doi: https://doi.org/10.1080/13102818.2014.984382
Li J, Dong N, Cheng S, Li X, Wang W, Xiang Y. Tetramethylpyrazine inhibits CTGF and Smad2/3 expression and proliferation of hepatic stellate cells. Biotechnol Biotechnol Equip. 2015 Jan 02;29(1):124-131. doi: 10.1080/13102818.2014.984382. Epub 2015 Jan 28. PMID: 26019625; PMCID: PMC4433940.
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Effect of Tetramethylpyrazine on Atherosclerosis and SCAP/SREBP-1c Signaling Pathway in ApoE.

Evidence-based complementary and alternative medicine : eCAM

Zhang Y, Ren P, Kang Q, Liu W, Li S, Li P, Liu H, Shang J, Zhang L, Gong Y, Zhou M.
PMID: 28491104
Evid Based Complement Alternat Med. 2017;2017:3121989. doi: 10.1155/2017/3121989. Epub 2017 Apr 12.

Lipid metabolism dysregulation plays a crucial role in the occurrence of atherosclerosis (As). SCAP/SREBP signaling is the main pathway for regulating lipid metabolism. Tetramethylpyrazine (TMP), a Traditional Chinese Medicine (TCM) for treating angina pectoris, has antiatherosclerotic effects and ameliorates...

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Zhang Y, Ren P, Kang Q, et al. Effect of Tetramethylpyrazine on Atherosclerosis and SCAP/SREBP-1c Signaling Pathway in ApoE. Evid Based Complement Alternat Med. 2017;2017:3121989doi: 10.1155/2017/3121989.
Zhang, Y., Ren, P., Kang, Q., Liu, W., Li, S., Li, P., Liu, H., Shang, J., Zhang, L., Gong, Y., & Zhou, M. (2017). Effect of Tetramethylpyrazine on Atherosclerosis and SCAP/SREBP-1c Signaling Pathway in ApoE. Evidence-based complementary and alternative medicine : eCAM, 20173121989. https://doi.org/10.1155/2017/3121989
Zhang, Ying, et al. "Effect of Tetramethylpyrazine on Atherosclerosis and SCAP/SREBP-1c Signaling Pathway in ApoE." Evidence-based complementary and alternative medicine : eCAM vol. 2017 (2017): 3121989. doi: https://doi.org/10.1155/2017/3121989
Zhang Y, Ren P, Kang Q, Liu W, Li S, Li P, Liu H, Shang J, Zhang L, Gong Y, Zhou M. Effect of Tetramethylpyrazine on Atherosclerosis and SCAP/SREBP-1c Signaling Pathway in ApoE. Evid Based Complement Alternat Med. 2017;2017:3121989. doi: 10.1155/2017/3121989. Epub 2017 Apr 12. PMID: 28491104; PMCID: PMC5405370.
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Effects of Tetramethylpyrazine on Functional Recovery and Neuronal Dendritic Plasticity after Experimental Stroke.

Evidence-based complementary and alternative medicine : eCAM

Lin JB, Zheng CJ, Zhang X, Chen J, Liao WJ, Wan Q.
PMID: 26379744
Evid Based Complement Alternat Med. 2015;2015:394926. doi: 10.1155/2015/394926. Epub 2015 Aug 26.

The 2,3,5,6-tetramethylpyrazine (TMP) has been widely used in the treatment of ischemic stroke by Chinese doctors. Here, we report the effects of TMP on functional recovery and dendritic plasticity after ischemic stroke. A classical model of middle cerebral artery...

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Lin JB, Zheng CJ, Zhang X, et al. Effects of Tetramethylpyrazine on Functional Recovery and Neuronal Dendritic Plasticity after Experimental Stroke. Evid Based Complement Alternat Med. 2015;2015:394926doi: 10.1155/2015/394926.
Lin, J. B., Zheng, C. J., Zhang, X., Chen, J., Liao, W. J., & Wan, Q. (2015). Effects of Tetramethylpyrazine on Functional Recovery and Neuronal Dendritic Plasticity after Experimental Stroke. Evidence-based complementary and alternative medicine : eCAM, 2015394926. https://doi.org/10.1155/2015/394926
Lin, Jun-Bin, et al. "Effects of Tetramethylpyrazine on Functional Recovery and Neuronal Dendritic Plasticity after Experimental Stroke." Evidence-based complementary and alternative medicine : eCAM vol. 2015 (2015): 394926. doi: https://doi.org/10.1155/2015/394926
Lin JB, Zheng CJ, Zhang X, Chen J, Liao WJ, Wan Q. Effects of Tetramethylpyrazine on Functional Recovery and Neuronal Dendritic Plasticity after Experimental Stroke. Evid Based Complement Alternat Med. 2015;2015:394926. doi: 10.1155/2015/394926. Epub 2015 Aug 26. PMID: 26379744; PMCID: PMC4563062.
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AgC(CN)3-based coordination polymers.

Inorganic chemistry

Abrahams BF, Batten SR, Hoskins BF, Robson R.
PMID: 12691573
Inorg Chem. 2003 Apr 21;42(8):2654-64. doi: 10.1021/ic026189s.

Reaction of Ag(tcm), tcm = tricyanomethanide, C(CN)(3)(-), with a range of terminal and bridging ligands results in formation of a series of new coordination polymers. Recrystallization of Ag(tcm) from acetonitrile generates Ag(tcm)(MeCN), which is composed of corrugated (6,3) sheets...

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Abrahams BF, Batten SR, Hoskins BF, et al. AgC(CN)3-based coordination polymers. Inorg Chem. 2003;42(8):2654-64doi: 10.1021/ic026189s.
Abrahams, B. F., Batten, S. R., Hoskins, B. F., & Robson, R. (2003). AgC(CN)3-based coordination polymers. Inorganic chemistry, 42(8), 2654-64. https://doi.org/10.1021/ic026189s
Abrahams, Brendan F, et al. "AgC(CN)3-based coordination polymers." Inorganic chemistry vol. 42,8 (2003): 2654-64. doi: https://doi.org/10.1021/ic026189s
Abrahams BF, Batten SR, Hoskins BF, Robson R. AgC(CN)3-based coordination polymers. Inorg Chem. 2003 Apr 21;42(8):2654-64. doi: 10.1021/ic026189s. PMID: 12691573.
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Asymmetric epoxidation with a photoactivated [Ru(salen)] complex.

Chemistry (Weinheim an der Bergstrasse, Germany)

Nakata K, Takeda T, Mihara J, Hamada T, Irie R, Katsuki T.
PMID: 11575779
Chemistry. 2001 Sep 03;7(17):3776-82. doi: 10.1002/1521-3765(20010903)7:17<3776::aid-chem3776>3.0.co;2-m.

(Nitrosyl)(salen)ruthenium(II) complex 1 was found to serve as an efficient catalyst for the epoxidation of conjugated olefins under photoirradiation, with 2,6-dichloropyridine N-oxide (2) or tetramethylpyrazine N,N'-dioxide as a stoichiometric oxidant. High enantioselectivity was achieved irrespective of the substitution pattern...

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Nakata K, Takeda T, Mihara J, et al. Asymmetric epoxidation with a photoactivated [Ru(salen)] complex. Chemistry. 2001;7(17):3776-82doi: 10.1002/1521-3765(20010903)7:17<3776::aid-chem3776>3.0.co;2-m.
Nakata, K., Takeda, T., Mihara, J., Hamada, T., Irie, R., & Katsuki, T. (2001). Asymmetric epoxidation with a photoactivated [Ru(salen)] complex. Chemistry (Weinheim an der Bergstrasse, Germany), 7(17), 3776-82. https://doi.org/10.1002/1521-3765(20010903)7:17<3776::aid-chem3776>3.0.co;2-m
Nakata, K, et al. "Asymmetric epoxidation with a photoactivated [Ru(salen)] complex." Chemistry (Weinheim an der Bergstrasse, Germany) vol. 7,17 (2001): 3776-82. doi: https://doi.org/10.1002/1521-3765(20010903)7:17<3776::aid-chem3776>3.0.co;2-m
Nakata K, Takeda T, Mihara J, Hamada T, Irie R, Katsuki T. Asymmetric epoxidation with a photoactivated [Ru(salen)] complex. Chemistry. 2001 Sep 03;7(17):3776-82. doi: 10.1002/1521-3765(20010903)7:17<3776::aid-chem3776>3.0.co;2-m. PMID: 11575779.
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Syntheses, structures, and photoluminescence of a series of silver(I) sulfonates with pyrazine derivatives.

Dalton transactions (Cambridge, England : 2003)

Liu HY, Wu H, Ma JF, Yang J, Liu YY.
PMID: 19771358
Dalton Trans. 2009 Oct 14;(38):7957-68. doi: 10.1039/b905483a. Epub 2009 Aug 06.

In this paper, ten novel silver(I) sulfonates containing pyrazine derivatives, [Ag(L1)(Pyr)(H2O)] (1), [Ag(L1)(2,3-Pyr)] (2), [Ag(L1)(2,5-Pyr)] x H2O (3), [Ag(L1)(2,3,5-Pyr)] (4), [Ag(L1)(2,3,5,6-Pyr)] (5), [Ag(L2)(Pyr)] (6), [Ag(L2)(2,3-Pyr)] (7), [Ag(L2)(2,6-Pyr)] (8), [Ag(L2)(2-Pyr)] (9), and [Ag(L2)(2,5-Pyr)] x H2O (10) (L1 = 3-amino-4-methylbenzenesulfonate anion;...

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Liu HY, Wu H, Ma JF, et al. Syntheses, structures, and photoluminescence of a series of silver(I) sulfonates with pyrazine derivatives. Dalton Trans. 2009;(38):7957-68doi: 10.1039/b905483a.
Liu, H. Y., Wu, H., Ma, J. F., Yang, J., & Liu, Y. Y. (2009). Syntheses, structures, and photoluminescence of a series of silver(I) sulfonates with pyrazine derivatives. Dalton transactions (Cambridge, England : 2003), (38), 7957-68. https://doi.org/10.1039/b905483a
Liu, Hai-Yan, et al. "Syntheses, structures, and photoluminescence of a series of silver(I) sulfonates with pyrazine derivatives." Dalton transactions (Cambridge, England : 2003) vol. ,38 (2009): 7957-68. doi: https://doi.org/10.1039/b905483a
Liu HY, Wu H, Ma JF, Yang J, Liu YY. Syntheses, structures, and photoluminescence of a series of silver(I) sulfonates with pyrazine derivatives. Dalton Trans. 2009 Oct 14;(38):7957-68. doi: 10.1039/b905483a. Epub 2009 Aug 06. PMID: 19771358.
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Assessment of robustness on analysis using headspace solid-phase microextraction and comprehensive two-dimensional gas chromatography through experimental designs.

Talanta

Oliveira LF, Braga SC, Filgueiras PR, Augusto F, Poppi RJ.
PMID: 25127599
Talanta. 2014 Nov;129:303-8. doi: 10.1016/j.talanta.2014.05.038. Epub 2014 May 28.

Plackett-Burman experimental design was applied for the robustness assessment of GC×GC-qMS (Comprehensive Two-Dimensional Gas Chromatography with Fast Quadrupolar Mass Spectrometric Detection) in quantitative and qualitative analysis of volatiles compounds from chocolate samples isolated by headspace solid-phase microextraction (HS-SPME). The...

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Oliveira LF, Braga SC, Filgueiras PR, et al. Assessment of robustness on analysis using headspace solid-phase microextraction and comprehensive two-dimensional gas chromatography through experimental designs. Talanta. 2014;129:303-8doi: 10.1016/j.talanta.2014.05.038.
Oliveira, L. F., Braga, S. C., Filgueiras, P. R., Augusto, F., & Poppi, R. J. (2014). Assessment of robustness on analysis using headspace solid-phase microextraction and comprehensive two-dimensional gas chromatography through experimental designs. Talanta, 129303-8. https://doi.org/10.1016/j.talanta.2014.05.038
Oliveira, Luciana F, et al. "Assessment of robustness on analysis using headspace solid-phase microextraction and comprehensive two-dimensional gas chromatography through experimental designs." Talanta vol. 129 (2014): 303-8. doi: https://doi.org/10.1016/j.talanta.2014.05.038
Oliveira LF, Braga SC, Filgueiras PR, Augusto F, Poppi RJ. Assessment of robustness on analysis using headspace solid-phase microextraction and comprehensive two-dimensional gas chromatography through experimental designs. Talanta. 2014 Nov;129:303-8. doi: 10.1016/j.talanta.2014.05.038. Epub 2014 May 28. PMID: 25127599.
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Tetramethylpyrazine reverses anxiety-like behaviors in a rat model of post-traumatic stress disorder.

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

Lee B, Shim I, Lee H, Hahm DH.
PMID: 30181699
Korean J Physiol Pharmacol. 2018 Sep;22(5):525-538. doi: 10.4196/kjpp.2018.22.5.525. Epub 2018 Aug 27.

Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, and anxiety that may involve the release of monoamines in the fear circuit. The reported pharmacological properties of tetramethylpyrazine (TMP) include anti-cancer, anti-diabetic, anti-atherosclerotic,...

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Lee B, Shim I, Lee H, et al. Tetramethylpyrazine reverses anxiety-like behaviors in a rat model of post-traumatic stress disorder. Korean J Physiol Pharmacol. 2018;22(5):525-538doi: 10.4196/kjpp.2018.22.5.525.
Lee, B., Shim, I., Lee, H., & Hahm, D. H. (2018). Tetramethylpyrazine reverses anxiety-like behaviors in a rat model of post-traumatic stress disorder. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 22(5), 525-538. https://doi.org/10.4196/kjpp.2018.22.5.525
Lee, Bombi, et al. "Tetramethylpyrazine reverses anxiety-like behaviors in a rat model of post-traumatic stress disorder." The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology vol. 22,5 (2018): 525-538. doi: https://doi.org/10.4196/kjpp.2018.22.5.525
Lee B, Shim I, Lee H, Hahm DH. Tetramethylpyrazine reverses anxiety-like behaviors in a rat model of post-traumatic stress disorder. Korean J Physiol Pharmacol. 2018 Sep;22(5):525-538. doi: 10.4196/kjpp.2018.22.5.525. Epub 2018 Aug 27. PMID: 30181699; PMCID: PMC6115350.
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Tetramethylpyrazine phosphate and borneol combination therapy synergistically attenuated ischemia-reperfusion injury of the hypothalamus and striatum via regulation of apoptosis and autophagy in a rat model.

American journal of translational research

Yu B, Ruan M, Liang T, Huang SW, Liu SJ, Cheng HB, Shen XC.
PMID: 29218081
Am J Transl Res. 2017 Nov 15;9(11):4807-4820. eCollection 2017.

The combination of tetramethylpyrazine (TMP) and borneol (BO) has shown promise for treatment of cerebral ischemia in clinical and experimental studies. However, the mechanism for the synergistic effect of these compounds is unclear. In this study, global cerebral ischemia-reperfusion...

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Yu B, Ruan M, Liang T, et al. Tetramethylpyrazine phosphate and borneol combination therapy synergistically attenuated ischemia-reperfusion injury of the hypothalamus and striatum via regulation of apoptosis and autophagy in a rat model. Am J Transl Res. 2017;9(11):4807-4820
Yu, B., Ruan, M., Liang, T., Huang, S. W., Liu, S. J., Cheng, H. B., & Shen, X. C. (2017). Tetramethylpyrazine phosphate and borneol combination therapy synergistically attenuated ischemia-reperfusion injury of the hypothalamus and striatum via regulation of apoptosis and autophagy in a rat model. American journal of translational research, 9(11), 4807-4820.
Yu, Bin, et al. "Tetramethylpyrazine phosphate and borneol combination therapy synergistically attenuated ischemia-reperfusion injury of the hypothalamus and striatum via regulation of apoptosis and autophagy in a rat model." American journal of translational research vol. 9,11 (2017): 4807-4820.
Yu B, Ruan M, Liang T, Huang SW, Liu SJ, Cheng HB, Shen XC. Tetramethylpyrazine phosphate and borneol combination therapy synergistically attenuated ischemia-reperfusion injury of the hypothalamus and striatum via regulation of apoptosis and autophagy in a rat model. Am J Transl Res. 2017 Nov 15;9(11):4807-4820. eCollection 2017. PMID: 29218081; PMCID: PMC5714767.
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Comparative pharmacokinetics of tetramethylpyrazine phosphate in rat plasma and extracellular fluid of brain after intranasal, intragastric and intravenous administration.

Acta pharmaceutica Sinica. B

Meng D, Lu H, Huang S, Wei M, Ding P, Xiao X, Xu Y, Wu C.
PMID: 26579367
Acta Pharm Sin B. 2014 Feb;4(1):74-8. doi: 10.1016/j.apsb.2013.12.009. Epub 2014 Jan 24.

The purpose of this study was to compare the pharmacokinetic profiles of tetramethylpyrazine phosphate (TMPP) in plasma and extracellular fluid of the cerebral cortex of rats via three delivery routes: intranasal (i.n.), intragastric (i.g.) and intravenous (i.v.) administration. After...

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Meng D, Lu H, Huang S, et al. Comparative pharmacokinetics of tetramethylpyrazine phosphate in rat plasma and extracellular fluid of brain after intranasal, intragastric and intravenous administration. Acta Pharm Sin B. 2014;4(1):74-8doi: 10.1016/j.apsb.2013.12.009.
Meng, D., Lu, H., Huang, S., Wei, M., Ding, P., Xiao, X., Xu, Y., & Wu, C. (2014). Comparative pharmacokinetics of tetramethylpyrazine phosphate in rat plasma and extracellular fluid of brain after intranasal, intragastric and intravenous administration. Acta pharmaceutica Sinica. B, 4(1), 74-8. https://doi.org/10.1016/j.apsb.2013.12.009
Meng, Dongmei, et al. "Comparative pharmacokinetics of tetramethylpyrazine phosphate in rat plasma and extracellular fluid of brain after intranasal, intragastric and intravenous administration." Acta pharmaceutica Sinica. B vol. 4,1 (2014): 74-8. doi: https://doi.org/10.1016/j.apsb.2013.12.009
Meng D, Lu H, Huang S, Wei M, Ding P, Xiao X, Xu Y, Wu C. Comparative pharmacokinetics of tetramethylpyrazine phosphate in rat plasma and extracellular fluid of brain after intranasal, intragastric and intravenous administration. Acta Pharm Sin B. 2014 Feb;4(1):74-8. doi: 10.1016/j.apsb.2013.12.009. Epub 2014 Jan 24. PMID: 26579367; PMCID: PMC4590719.
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Role and mechanism of nursing cooperation and tetramethylpyrazine application in post-operative pain in patients undergoing total knee arthroplasty.

Experimental and therapeutic medicine

Liu C, Liu R, Tang M, Yang X, Gong X.
PMID: 30867722
Exp Ther Med. 2019 Mar;17(3):2366-2372. doi: 10.3892/etm.2019.7203. Epub 2019 Jan 25.

The aim of the present study was to investigate the effect of nursing cooperation on the post-operative complication of pain following total knee arthroplasty (TKA) and to explore the effects of tetramethylpyrazine (TMP) application on post-TKA pain. A total...

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Liu C, Liu R, Tang M, et al. Role and mechanism of nursing cooperation and tetramethylpyrazine application in post-operative pain in patients undergoing total knee arthroplasty. Exp Ther Med. 2019;17(3):2366-2372doi: 10.3892/etm.2019.7203.
Liu, C., Liu, R., Tang, M., Yang, X., & Gong, X. (2019). Role and mechanism of nursing cooperation and tetramethylpyrazine application in post-operative pain in patients undergoing total knee arthroplasty. Experimental and therapeutic medicine, 17(3), 2366-2372. https://doi.org/10.3892/etm.2019.7203
Liu, Chang, et al. "Role and mechanism of nursing cooperation and tetramethylpyrazine application in post-operative pain in patients undergoing total knee arthroplasty." Experimental and therapeutic medicine vol. 17,3 (2019): 2366-2372. doi: https://doi.org/10.3892/etm.2019.7203
Liu C, Liu R, Tang M, Yang X, Gong X. Role and mechanism of nursing cooperation and tetramethylpyrazine application in post-operative pain in patients undergoing total knee arthroplasty. Exp Ther Med. 2019 Mar;17(3):2366-2372. doi: 10.3892/etm.2019.7203. Epub 2019 Jan 25. PMID: 30867722; PMCID: PMC6395958.
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