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Showing 1 to 7 of 7 entries
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The impact of miRNA target sites in coding sequences and in 3'UTRs.

PloS one

Fang Z, Rajewsky N.
PMID: 21445367
PLoS One. 2011 Mar 22;6(3):e18067. doi: 10.1371/journal.pone.0018067.

Animal miRNAs are a large class of small regulatory RNAs that are known to directly and negatively regulate the expression of a large fraction of all protein encoding genes. The identification and characterization of miRNA targets is thus a...

dbMTS: A comprehensive database of putative human microRNA target site SNVs and their functional predictions.

Human mutation

Li C, Mou C, Swartz MD, Yu B, Bai Y, Tu Y, Liu X.
PMID: 32227657
Hum Mutat. 2020 Jun;41(6):1123-1130. doi: 10.1002/humu.24020. Epub 2020 Apr 06.

MicroRNAs (miRNA) are short noncoding RNAs that can repress the expression of protein-coding messenger RNAs (mRNAs) by binding to the 3'-untranslated region (UTR) of the target. Genetic mutations such as single nucleotide variants (SNVs) in the 3'-UTR of the...

Distinct expression of select and transcriptome-wide isolated 3'UTRs suggests critical roles in development and transition states.

PloS one

Ji S, Yang Z, Gozali L, Kenney T, Kocabas A, Jinsook Park C, Hynes M.
PMID: 33951080
PLoS One. 2021 May 05;16(5):e0250669. doi: 10.1371/journal.pone.0250669. eCollection 2021.

Mature mRNA molecules are expected to be comprised of a 5'UTR, a 3'UTR and a coding region (CDS). Unexpectedly, however, there have been multiple recent reports of widespread differential expression of mRNA 3'UTRs and their cognate coding regions (CDS),...

Internet resources for the functional analysis of 5' and 3' untranslated regions of eukaryotic mRNAs.

Trends in genetics : TIG

Pesole G, Liuni S.
PMID: 10461207
Trends Genet. 1999 Sep;15(9):378. doi: 10.1016/s0168-9525(99)01795-3.

No abstract available.

Homo sapiens exhibit a distinct pattern of CNV genes regulation: an important role of miRNAs and SNPs in expression plasticity.

Scientific reports

Dweep H, Kubikova N, Gretz N, Voskarides K, Felekkis K.
PMID: 26178010
Sci Rep. 2015 Jul 16;5:12163. doi: 10.1038/srep12163.

Gene expression regulation is a complex and highly organized process involving a variety of genomic factors. It is widely accepted that differences in gene expression can contribute to the phenotypic variability between species, and that their interpretation can aid...

The emerging roles of 3' untranslated regions in cancer.

Cancer letters

Li J, Lu X.
PMID: 23726838
Cancer Lett. 2013 Aug 28;337(1):22-5. doi: 10.1016/j.canlet.2013.05.034. Epub 2013 May 29.

Accumulating evidence suggests that 3' untranlated regions (3' UTRs) are critical for spatial and temporal gene expression in both physiological and pathological conditions. The reprogramming of 3' UTRs by various means is a common phenomenon in cancer; disturbances of...

Detecting alternative polyadenylation from microarray data.

Methods in molecular biology (Clifton, N.J.)

Lembo A, Provero P.
PMID: 24590786
Methods Mol Biol. 2014;1125:141-4. doi: 10.1007/978-1-62703-971-0_12.

Gene regulation at the posttranscriptional level is often mediated by trans-acting factors binding the 3' untranslated region (3' UTR) of messenger RNAs (mRNAs). Alternative mRNA isoforms differing only in their 3' UTR can thus be differentially regulated, and it...

Showing 1 to 7 of 7 entries