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Rapid and powerful detection of subtle allelic imbalance from exome sequencing data with hapLOHseq.

Bioinformatics (Oxford, England)

San Lucas FA, Sivakumar S, Vattathil S, Fowler J, Vilar E, Scheet P.
PMID: 27288500
Bioinformatics. 2016 Oct 01;32(19):3015-7. doi: 10.1093/bioinformatics/btw340. Epub 2016 Jun 10.

MOTIVATION: The detection of subtle genomic allelic imbalance events has many potential applications. For example, identifying cancer-associated allelic imbalanced regions in low tumor-cellularity samples or in low-proportion tumor subclones can be used for early cancer detection, prognostic assessment and...

Showing 1 to 1 of 1 entries