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On clinically relevant differences and shifted null hypotheses.

Methods of information in medicine

Victor N.
PMID: 3670099
Methods Inf Med. 1987 Jul;26(3):109-16.

No abstract available.

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Victor N. On clinically relevant differences and shifted null hypotheses. Methods Inf Med. 1987;26(3):109-16
Victor, N. (1987). On clinically relevant differences and shifted null hypotheses. Methods of information in medicine, 26(3), 109-16.
Victor, N. "On clinically relevant differences and shifted null hypotheses." Methods of information in medicine vol. 26,3 (1987): 109-16.
Victor N. On clinically relevant differences and shifted null hypotheses. Methods Inf Med. 1987 Jul;26(3):109-16. PMID: 3670099.
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A simple method for the estimation of interaction bias in crossover studies.

Journal of clinical pharmacology

Cleophas TJ.
PMID: 2243151
J Clin Pharmacol. 1990 Nov;30(11):1036-40. doi: 10.1002/j.1552-4604.1990.tb03591.x.

The crossover trial is considered the most powerful means of determining the efficacy of new drugs. However this study design is frequently invalidated by treatment-by-period interaction. If, for example, the effect of the first treatment period carries on into...

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Cleophas TJ. A simple method for the estimation of interaction bias in crossover studies. J Clin Pharmacol. 1990;30(11):1036-40doi: 10.1002/j.1552-4604.1990.tb03591.x.
Cleophas, T. J. (1990). A simple method for the estimation of interaction bias in crossover studies. Journal of clinical pharmacology, 30(11), 1036-40. https://doi.org/10.1002/j.1552-4604.1990.tb03591.x
Cleophas, T J. "A simple method for the estimation of interaction bias in crossover studies." Journal of clinical pharmacology vol. 30,11 (1990): 1036-40. doi: https://doi.org/10.1002/j.1552-4604.1990.tb03591.x
Cleophas TJ. A simple method for the estimation of interaction bias in crossover studies. J Clin Pharmacol. 1990 Nov;30(11):1036-40. doi: 10.1002/j.1552-4604.1990.tb03591.x. PMID: 2243151.
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Surrogate endpoints: a basis for a rational approach.

European journal of clinical pharmacology

Boissel JP, Collet JP, Moleur P, Haugh M.
PMID: 1425885
Eur J Clin Pharmacol. 1992;43(3):235-44. doi: 10.1007/BF02333016.

In clinical trials, the clinical endpoint is often replaced by an intermediate endpoint, known in some instances as a "surrogate" endpoint. The reasons for the substitution are often both practical and financial. At present, no theoretical basis or practical...

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Boissel JP, Collet JP, Moleur P, et al. Surrogate endpoints: a basis for a rational approach. Eur J Clin Pharmacol. 1992;43(3):235-44doi: 10.1007/BF02333016.
Boissel, J. P., Collet, J. P., Moleur, P., & Haugh, M. (1992). Surrogate endpoints: a basis for a rational approach. European journal of clinical pharmacology, 43(3), 235-44. https://doi.org/10.1007/BF02333016
Boissel, J P, et al. "Surrogate endpoints: a basis for a rational approach." European journal of clinical pharmacology vol. 43,3 (1992): 235-44. doi: https://doi.org/10.1007/BF02333016
Boissel JP, Collet JP, Moleur P, Haugh M. Surrogate endpoints: a basis for a rational approach. Eur J Clin Pharmacol. 1992;43(3):235-44. doi: 10.1007/BF02333016. PMID: 1425885.
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[The pyramids of cardiology].

Giornale italiano di cardiologia

Masoni A.
PMID: 3732712
G Ital Cardiol. 1986 Mar;16(3):191-5.

No abstract available.

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Masoni A. Le piramidi della cardiologia. [The pyramids of cardiology]. G Ital Cardiol. 1986;16(3):191-5
Masoni, A. (1986). Le piramidi della cardiologia. [The pyramids of cardiology]. Giornale italiano di cardiologia, 16(3), 191-5.
Masoni, A. "Le piramidi della cardiologia." [The pyramids of cardiology]. Giornale italiano di cardiologia vol. 16,3 (1986): 191-5.
Masoni A. Le piramidi della cardiologia. [The pyramids of cardiology]. G Ital Cardiol. 1986 Mar;16(3):191-5. Italian. PMID: 3732712.
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Loss of power from an optimistic alternative hypothesis.

Statistics in medicine

Blumenson LE.
PMID: 3368672
Stat Med. 1988 Apr;7(4):457-66. doi: 10.1002/sim.4780070402.

In the planning of a clinical trial to compare the proportion of responses to two treatments one determines the sample size to yield the desired power of achieving a significant difference at a pre-selected type I error under the...

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Blumenson LE. Loss of power from an optimistic alternative hypothesis. Stat Med. 1988;7(4):457-66doi: 10.1002/sim.4780070402.
Blumenson, L. E. (1988). Loss of power from an optimistic alternative hypothesis. Statistics in medicine, 7(4), 457-66. https://doi.org/10.1002/sim.4780070402
Blumenson, L E. "Loss of power from an optimistic alternative hypothesis." Statistics in medicine vol. 7,4 (1988): 457-66. doi: https://doi.org/10.1002/sim.4780070402
Blumenson LE. Loss of power from an optimistic alternative hypothesis. Stat Med. 1988 Apr;7(4):457-66. doi: 10.1002/sim.4780070402. PMID: 3368672.
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The summarizing of clinical experiments by significance levels.

Statistics in medicine

Anscombe FJ.
PMID: 2218173
Stat Med. 1990 Jun;9(6):703-8. doi: 10.1002/sim.4780090617.

For a controlled clinical experiment in which two alternative treatments are compared, the statistical report often culminates in a significance test of the null hypothesis of no difference between the treatments, and significance at the 5 per cent level...

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Anscombe FJ. The summarizing of clinical experiments by significance levels. Stat Med. 1990;9(6):703-8doi: 10.1002/sim.4780090617.
Anscombe, F. J. (1990). The summarizing of clinical experiments by significance levels. Statistics in medicine, 9(6), 703-8. https://doi.org/10.1002/sim.4780090617
Anscombe, F J. "The summarizing of clinical experiments by significance levels." Statistics in medicine vol. 9,6 (1990): 703-8. doi: https://doi.org/10.1002/sim.4780090617
Anscombe FJ. The summarizing of clinical experiments by significance levels. Stat Med. 1990 Jun;9(6):703-8. doi: 10.1002/sim.4780090617. PMID: 2218173.
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[Clinical trials in general practice. The telematics solution].

Therapie

Boissel JP, Alamercery Y, Collet JP, Luciani J, Leizorovicz A.
PMID: 2080485
Therapie. 1990 Nov-Dec;45(6):471-4.

Clinical trials with private practitioners pose a series of specific problems. Among them, the large number of investigators, the scarcity of time that each investigator can allocate to the study, may be eased by using computerized network. The telematic...

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Boissel JP, Alamercery Y, Collet JP, et al. Essais cliniques en médecine praticienne. La solution télématique. [Clinical trials in general practice. The telematics solution]. Therapie. 1990;45(6):471-4
Boissel, J. P., Alamercery, Y., Collet, J. P., Luciani, J., & Leizorovicz, A. (1990). Essais cliniques en médecine praticienne. La solution télématique. [Clinical trials in general practice. The telematics solution]. Therapie, 45(6), 471-4.
Boissel, J P, et al. "Essais cliniques en médecine praticienne. La solution télématique." [Clinical trials in general practice. The telematics solution]. Therapie vol. 45,6 (1990): 471-4.
Boissel JP, Alamercery Y, Collet JP, Luciani J, Leizorovicz A. Essais cliniques en médecine praticienne. La solution télématique. [Clinical trials in general practice. The telematics solution]. Therapie. 1990 Nov-Dec;45(6):471-4. French. PMID: 2080485.
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[Assessment of group composition in clinical studies with reference to ethical aspects].

Zeitschrift fur arztliche Fortbildung

Hiller E.
PMID: 2378113
Z Arztl Fortbild (Jena). 1990;84(7):343-5.

No abstract available.

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Hiller E. Uber die Schätzung von Gruppenumfängen bei klinischen Studien unter Beachtung ethischer Gesichtspunkte. [Assessment of group composition in clinical studies with reference to ethical aspects]. Z Arztl Fortbild (Jena). 1990;84(7):343-5
Hiller, E. (1990). Uber die Schätzung von Gruppenumfängen bei klinischen Studien unter Beachtung ethischer Gesichtspunkte. [Assessment of group composition in clinical studies with reference to ethical aspects]. Zeitschrift fur arztliche Fortbildung, 84(7), 343-5.
Hiller, E. "Uber die Schätzung von Gruppenumfängen bei klinischen Studien unter Beachtung ethischer Gesichtspunkte." [Assessment of group composition in clinical studies with reference to ethical aspects]. Zeitschrift fur arztliche Fortbildung vol. 84,7 (1990): 343-5.
Hiller E. Uber die Schätzung von Gruppenumfängen bei klinischen Studien unter Beachtung ethischer Gesichtspunkte. [Assessment of group composition in clinical studies with reference to ethical aspects]. Z Arztl Fortbild (Jena). 1990;84(7):343-5. German. PMID: 2378113.
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How many raters? Toward the most reliable diagnostic consensus.

Statistics in medicine

Kraemer HC.
PMID: 1609173
Stat Med. 1992 Feb 15;11(3):317-31. doi: 10.1002/sim.4780110305.

When faced with a decision whether or not to treat a patient, to enter or to withdraw a patient from a clinical trial, or any other such binary decision, based on diagnosis with unsatisfactory reliability, can a consensus diagnosis...

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Kraemer HC. How many raters? Toward the most reliable diagnostic consensus. Stat Med. 1992;11(3):317-31doi: 10.1002/sim.4780110305.
Kraemer, H. C. (1992). How many raters? Toward the most reliable diagnostic consensus. Statistics in medicine, 11(3), 317-31. https://doi.org/10.1002/sim.4780110305
Kraemer, H C. "How many raters? Toward the most reliable diagnostic consensus." Statistics in medicine vol. 11,3 (1992): 317-31. doi: https://doi.org/10.1002/sim.4780110305
Kraemer HC. How many raters? Toward the most reliable diagnostic consensus. Stat Med. 1992 Feb 15;11(3):317-31. doi: 10.1002/sim.4780110305. PMID: 1609173.
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[Experimental studies].

Atencion primaria

Salleras Sanmartí L.
PMID: 2518902
Aten Primaria. 1989 Dec;6(10):745-50.

No abstract available.

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Salleras Sanmartí L. Estudios experimentales. [Experimental studies]. Aten Primaria. 1989;6(10):745-50
Salleras Sanmartí, L. (1989). Estudios experimentales. [Experimental studies]. Atencion primaria, 6(10), 745-50.
Salleras Sanmartí, L. "Estudios experimentales." [Experimental studies]. Atencion primaria vol. 6,10 (1989): 745-50.
Salleras Sanmartí L. Estudios experimentales. [Experimental studies]. Aten Primaria. 1989 Dec;6(10):745-50. Spanish. PMID: 2518902.
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Assessing clinical trials--between-observer variation.

British medical journal (Clinical research ed.)

Gore SM.
PMID: 6788259
Br Med J (Clin Res Ed). 1981 Jul 04;283(6283):40-3. doi: 10.1136/bmj.283.6283.40.

No abstract available.

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Gore SM. Assessing clinical trials--between-observer variation. Br Med J (Clin Res Ed). 1981;283(6283):40-3doi: 10.1136/bmj.283.6283.40.
Gore, S. M. (1981). Assessing clinical trials--between-observer variation. British medical journal (Clinical research ed.), 283(6283), 40-3. https://doi.org/10.1136/bmj.283.6283.40
Gore, S M. "Assessing clinical trials--between-observer variation." British medical journal (Clinical research ed.) vol. 283,6283 (1981): 40-3. doi: https://doi.org/10.1136/bmj.283.6283.40
Gore SM. Assessing clinical trials--between-observer variation. Br Med J (Clin Res Ed). 1981 Jul 04;283(6283):40-3. doi: 10.1136/bmj.283.6283.40. PMID: 6788259; PMCID: PMC1505973.
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Assessing, clinical trials-- protocol and monitoring.

British medical journal (Clinical research ed.)

Gore SM.
PMID: 6788334
Br Med J (Clin Res Ed). 1981 Aug 01;283(6287):369-71. doi: 10.1136/bmj.283.6287.369.

No abstract available.

Cite
Gore SM. Assessing, clinical trials-- protocol and monitoring. Br Med J (Clin Res Ed). 1981;283(6287):369-71doi: 10.1136/bmj.283.6287.369.
Gore, S. M. (1981). Assessing, clinical trials-- protocol and monitoring. British medical journal (Clinical research ed.), 283(6287), 369-71. https://doi.org/10.1136/bmj.283.6287.369
Gore, S M. "Assessing, clinical trials-- protocol and monitoring." British medical journal (Clinical research ed.) vol. 283,6287 (1981): 369-71. doi: https://doi.org/10.1136/bmj.283.6287.369
Gore SM. Assessing, clinical trials-- protocol and monitoring. Br Med J (Clin Res Ed). 1981 Aug 01;283(6287):369-71. doi: 10.1136/bmj.283.6287.369. PMID: 6788334; PMCID: PMC1506159.
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Showing 1 to 12 of 386 entries