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The microsatellite instable subset of colorectal cancer is a particularly good candidate for checkpoint blockade immunotherapy.

Cancer discovery

Xiao Y, Freeman GJ.
PMID: 25583798
Cancer Discov. 2015 Jan;5(1):16-8. doi: 10.1158/2159-8290.CD-14-1397.

The microsatellite instable (MSI) subset of colorectal cancer exhibits an active Th1/CTL immune microenvironment, probably due to recognition of a high number of tumor neoantigens. However, the high expression of checkpoint molecules PD-1, PD-L1, CTLA-4, LAG-3, and IDO in...

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