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Cysteinome: The first comprehensive database for proteins with targetable cysteine and their covalent inhibitors.

Biochemical and biophysical research communications

Wu S, Luo Howard H, Wang H, Zhao W, Hu Q, Yang Y.
PMID: 27553277
Biochem Biophys Res Commun. 2016 Sep 23;478(3):1268-73. doi: 10.1016/j.bbrc.2016.08.109. Epub 2016 Aug 20.

The covalent modification of intrinsically nucleophilic cysteine in proteins is crucial for diverse biochemical events. Bioinformatics approaches may prove useful in the design and discovery of covalent molecules targeting the cysteine in proteins to tune their functions and activities....

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