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Showing 1 to 12 of 646 entries
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Methylation analysis by microarray.

Methods in molecular biology (Clifton, N.J.)

Deatherage DE, Potter D, Yan PS, Huang TH, Lin S.
PMID: 19488875
Methods Mol Biol. 2009;556:117-39. doi: 10.1007/978-1-60327-192-9_9.

Differential methylation hybridization (DMH) is a high-throughput DNA methylation screening tool that utilizes methylation-sensitive restriction enzymes to profile methylated fragments by hybridizing them to a CpG island microarray. This array contains probes spanning all the 27,800 islands annotated in...

Increasing the specificity and function of DNA microarrays by processing arrays at different stringencies.

Analytical and bioanalytical chemistry

Dufva M, Petersen J, Poulsen L.
PMID: 19495730
Anal Bioanal Chem. 2009 Oct;395(3):669-77. doi: 10.1007/s00216-009-2848-z. Epub 2009 Jun 03.

DNA microarrays have for a decade been the only platform for genome-wide analysis and have provided a wealth of information about living organisms. DNA microarrays are processed today under one condition only, which puts large demands on assay development...

Numerical studies of electrokinetic control of DNA concentration in a closed-end microchannel.

Electrophoresis

Daghighi Y, Li D.
PMID: 20191548
Electrophoresis. 2010 Mar;31(5):868-78. doi: 10.1002/elps.200900447.

A major challenge in lab-on-a-chip devices is how to concentrate sample molecules from a dilute solution, which is critical to the effectiveness and the detection limit of on-chip bio-chemical reactions. A numerical study of sample concentration control by electrokinetic...

Well-less capillary array electrophoresis chip using hydrophilic sample bridges.

Analytical chemistry

Kim YH, Yang I, Park SR.
PMID: 17927141
Anal Chem. 2007 Dec 01;79(23):9205-10. doi: 10.1021/ac071115p. Epub 2007 Oct 10.

An innovative sample introduction method that facilitates extreme simplification of the layout of a capillary array electrophoresis (CAE) chip is described. Multiple samples were directly injected onto CAE channels from sample loaders using hydrophilic sample bridges, thus obviating auxiliary...

Bringing DNA-guided medicine to the Hispanic population.

Puerto Rico health sciences journal

Ruanõ G.
PMID: 19715119
P R Health Sci J. 2009 Sep;28(3):266-7.

No abstract available.

Selection effects and database screening in forensic science.

Forensic science international

Sjerps M, Meester R.
PMID: 19747786
Forensic Sci Int. 2009 Nov 20;192(1):56-61. doi: 10.1016/j.forsciint.2009.07.022. Epub 2009 Sep 10.

We argue that it is, in principle, not difficult to deal with selection effects in forensic science. If a suspect is selected through a process that is related to the forensic evidence, then the strength of the evidence will...

High-throughput single nucleotide polymorphism genotyping using nanofluidic Dynamic Arrays.

BMC genomics

Wang J, Lin M, Crenshaw A, Hutchinson A, Hicks B, Yeager M, Berndt S, Huang WY, Hayes RB, Chanock SJ, Jones RC, Ramakrishnan R.
PMID: 19943955
BMC Genomics. 2009 Nov 28;10:561. doi: 10.1186/1471-2164-10-561.

BACKGROUND: Single nucleotide polymorphisms (SNPs) have emerged as the genetic marker of choice for mapping disease loci and candidate gene association studies, because of their high density and relatively even distribution in the human genomes. There is a need...

[How a long linear molecule can be straightened on a support].

Biofizika

Namiot VA.
PMID: 19334628
Biofizika. 2009 Jan-Feb;54(1):13-5.

A relatively simple means is proposed for fastening a macromolecule such as DNA in a straight line on a dielectric support (which is essential for "fast reading" of sequences by physical methods). A randomly coiled molecule in solution can...

X-ray crystallography and the elucidation of the structure of DNA.

AJR. American journal of roentgenology

McGregor HC, Gunderman RB.
PMID: 21606255
AJR Am J Roentgenol. 2011 Jun;196(6):W689-92. doi: 10.2214/AJR.10.5479.

OBJECTIVE: Since their discovery by Roentgen in 1895, x-rays have contributed to some of the most important advances in science. X-ray crystallography is an imaging technique that uses x-ray diffraction to evaluate the molecular structure of a crystalline solid....

Consequences of local inter-strand dehybridization for large-amplitude bending fluctuations of double-stranded DNA.

The Journal of chemical physics

Sivak DA, Geissler PL.
PMID: 22299918
J Chem Phys. 2012 Jan 28;136(4):045102. doi: 10.1063/1.3679654.

The wormlike chain model of DNA bending accurately reproduces single-molecule force-extension profiles of long (kilobase) chains. These bending statistics over large scales do not, however, establish a unique microscopic model for elasticity at the 1-10 basepair (bp) scale, which...

Socially desirable responses in relation to grade level.

Child development

CRUSE DB.
PMID: 14024065
Child Dev. 1963 Sep;34:777-89. doi: 10.1111/j.1467-8624.1963.tb05966.x.

No abstract available.

I-motif-programmed functionalization of DNA nanocircles.

Journal of the American Chemical Society

Li T, Famulok M.
PMID: 23312021
J Am Chem Soc. 2013 Jan 30;135(4):1593-9. doi: 10.1021/ja3118224. Epub 2013 Jan 22.

The folding of various intra- and intermolecular i-motif DNAs is systematically studied to expand the toolbox for the control of mechanical operations in DNA nanoarchitectures. We analyzed i-motif DNAs with two C-tracts under acidic conditions by gel electrophoresis, circular...

Showing 1 to 12 of 646 entries