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Recent approaches to medicinal chemistry and therapeutic potential of dipeptidyl peptidase-4 (DPP-4) inhibitors.

European journal of medicinal chemistry

Patel BD, Ghate MD.
PMID: 24531198
Eur J Med Chem. 2014 Mar 03;74:574-605. doi: 10.1016/j.ejmech.2013.12.038. Epub 2014 Jan 11.

Dipeptidyl peptidase-4 (DPP-4) is one of the widely explored novel targets for Type 2 diabetes mellitus (T2DM) currently. Research has been focused on the strategy to preserve the endogenous glucagon like peptide (GLP)-1 activity by inhibiting the DPP-4 action....

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