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Metagenome Analysis: a Powerful Tool for Enzyme Bioprospecting.

Applied biochemistry and biotechnology

Madhavan A, Sindhu R, Parameswaran B, Sukumaran RK, Pandey A.
PMID: 28815469
Appl Biochem Biotechnol. 2017 Oct;183(2):636-651. doi: 10.1007/s12010-017-2568-3. Epub 2017 Aug 16.

Microorganisms are found throughout every corner of nature, and vast number of microorganisms is difficult to cultivate by classical microbiological techniques. The advent of metagenomics has revolutionized the field of microbial biotechnology. Metagenomics allow the recovery of genetic material...

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Madhavan A, Sindhu R, Parameswaran B, et al. Metagenome Analysis: a Powerful Tool for Enzyme Bioprospecting. Appl Biochem Biotechnol. 2017;183(2):636-651doi: 10.1007/s12010-017-2568-3.
Madhavan, A., Sindhu, R., Parameswaran, B., Sukumaran, R. K., & Pandey, A. (2017). Metagenome Analysis: a Powerful Tool for Enzyme Bioprospecting. Applied biochemistry and biotechnology, 183(2), 636-651. https://doi.org/10.1007/s12010-017-2568-3
Madhavan, Aravind, et al. "Metagenome Analysis: a Powerful Tool for Enzyme Bioprospecting." Applied biochemistry and biotechnology vol. 183,2 (2017): 636-651. doi: https://doi.org/10.1007/s12010-017-2568-3
Madhavan A, Sindhu R, Parameswaran B, Sukumaran RK, Pandey A. Metagenome Analysis: a Powerful Tool for Enzyme Bioprospecting. Appl Biochem Biotechnol. 2017 Oct;183(2):636-651. doi: 10.1007/s12010-017-2568-3. Epub 2017 Aug 16. PMID: 28815469.
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Validation of the performance of a comprehensive genotyping assay panel of single nucleotide polymorphisms in drug metabolism enzyme genes.

Human mutation

Welch RA, Lazaruk K, Haque KA, Hyland F, Xiao N, Wronka L, Burdett L, Chanock SJ, Ingber D, De La Vega FM, Yeager M.
PMID: 18327779
Hum Mutat. 2008 May;29(5):750-6. doi: 10.1002/humu.20703.

A class of genes, known as drug metabolism enzymes (DMEs) are responsible for the metabolism and transport of drugs and other xenobiotics. Variation in DME genes most likely accounts for a proportion of the variability in drug response in...

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Welch RA, Lazaruk K, Haque KA, et al. Validation of the performance of a comprehensive genotyping assay panel of single nucleotide polymorphisms in drug metabolism enzyme genes. Hum Mutat. 2008;29(5):750-6doi: 10.1002/humu.20703.
Welch, R. A., Lazaruk, K., Haque, K. A., Hyland, F., Xiao, N., Wronka, L., Burdett, L., Chanock, S. J., Ingber, D., De La Vega, F. M., & Yeager, M. (2008). Validation of the performance of a comprehensive genotyping assay panel of single nucleotide polymorphisms in drug metabolism enzyme genes. Human mutation, 29(5), 750-6. https://doi.org/10.1002/humu.20703
Welch, Robert A, et al. "Validation of the performance of a comprehensive genotyping assay panel of single nucleotide polymorphisms in drug metabolism enzyme genes." Human mutation vol. 29,5 (2008): 750-6. doi: https://doi.org/10.1002/humu.20703
Welch RA, Lazaruk K, Haque KA, Hyland F, Xiao N, Wronka L, Burdett L, Chanock SJ, Ingber D, De La Vega FM, Yeager M. Validation of the performance of a comprehensive genotyping assay panel of single nucleotide polymorphisms in drug metabolism enzyme genes. Hum Mutat. 2008 May;29(5):750-6. doi: 10.1002/humu.20703. PMID: 18327779.
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Puzzling over orphan enzymes.

Cellular and molecular life sciences : CMLS

Lespinet O, Labedan B.
PMID: 16465439
Cell Mol Life Sci. 2006 Mar;63(5):517-23. doi: 10.1007/s00018-005-5520-6.

Despite the current availability of several hundreds of thousands of amino acid sequences, more than 39% of the well-defined enzyme activities (EC numbers) are not associated with any sequence in major public databases. This wide gap separating knowledge of...

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Lespinet O, Labedan B. Puzzling over orphan enzymes. Cell Mol Life Sci. 2006;63(5):517-23doi: 10.1007/s00018-005-5520-6.
Lespinet, O., & Labedan, B. (2006). Puzzling over orphan enzymes. Cellular and molecular life sciences : CMLS, 63(5), 517-23. https://doi.org/10.1007/s00018-005-5520-6
Lespinet, O, and Labedan, B. "Puzzling over orphan enzymes." Cellular and molecular life sciences : CMLS vol. 63,5 (2006): 517-23. doi: https://doi.org/10.1007/s00018-005-5520-6
Lespinet O, Labedan B. Puzzling over orphan enzymes. Cell Mol Life Sci. 2006 Mar;63(5):517-23. doi: 10.1007/s00018-005-5520-6. PMID: 16465439.
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The importance of ensemble averaging in enzyme kinetics.

Accounts of chemical research

Masgrau L, Truhlar DG.
PMID: 25539028
Acc Chem Res. 2015 Feb 17;48(2):431-8. doi: 10.1021/ar500319e. Epub 2014 Dec 24.

CONSPECTUS: The active site of an enzyme is surrounded by a fluctuating environment of protein and solvent conformational states, and a realistic calculation of chemical reaction rates and kinetic isotope effects of enzyme-catalyzed reactions must take account of this...

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Masgrau L, Truhlar DG. The importance of ensemble averaging in enzyme kinetics. Acc Chem Res. 2014;48(2):431-8doi: 10.1021/ar500319e.
Masgrau, L., & Truhlar, D. G. (2015). The importance of ensemble averaging in enzyme kinetics. Accounts of chemical research, 48(2), 431-8. https://doi.org/10.1021/ar500319e
Masgrau, Laura, and Truhlar, Donald G. "The importance of ensemble averaging in enzyme kinetics." Accounts of chemical research vol. 48,2 (2015): 431-8. doi: https://doi.org/10.1021/ar500319e
Masgrau L, Truhlar DG. The importance of ensemble averaging in enzyme kinetics. Acc Chem Res. 2015 Feb 17;48(2):431-8. doi: 10.1021/ar500319e. Epub 2014 Dec 24. PMID: 25539028; PMCID: PMC4334256.
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Thematic minireview series on enzyme evolution in the post-genomic era.

The Journal of biological chemistry

Allewell NM.
PMID: 22069328
J Biol Chem. 2012 Jan 02;287(1):1-2. doi: 10.1074/jbc.R111.307322. Epub 2011 Nov 08.

The emergence of genomics; ongoing computational advances; and the development of large-scale sequence, structural, and functional databases have created important new interdisciplinary linkages between molecular evolution, molecular biology, and enzymology. The five minireviews in this series survey advances and...

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Allewell NM. Thematic minireview series on enzyme evolution in the post-genomic era. J Biol Chem. 2011;287(1):1-2doi: 10.1074/jbc.R111.307322.
Allewell, N. M. (2012). Thematic minireview series on enzyme evolution in the post-genomic era. The Journal of biological chemistry, 287(1), 1-2. https://doi.org/10.1074/jbc.R111.307322
Allewell, Norma M. "Thematic minireview series on enzyme evolution in the post-genomic era." The Journal of biological chemistry vol. 287,1 (2012): 1-2. doi: https://doi.org/10.1074/jbc.R111.307322
Allewell NM. Thematic minireview series on enzyme evolution in the post-genomic era. J Biol Chem. 2012 Jan 02;287(1):1-2. doi: 10.1074/jbc.R111.307322. Epub 2011 Nov 08. PMID: 22069328; PMCID: PMC3249060.
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