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Epigenetic Drug Discovery: Great Potential and Significant Challenges.

Assay and drug development technologies

Cummings R.
PMID: 26065555
Assay Drug Dev Technol. 2015 May;13(4):185. doi: 10.1089/adt.2015.29000.rcu.

No abstract available.

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Cummings R. Epigenetic Drug Discovery: Great Potential and Significant Challenges. Assay Drug Dev Technol. 2015;13(4):185doi: 10.1089/adt.2015.29000.rcu.
Cummings, R. (2015). Epigenetic Drug Discovery: Great Potential and Significant Challenges. Assay and drug development technologies, 13(4), 185. https://doi.org/10.1089/adt.2015.29000.rcu
Cummings, Rich. "Epigenetic Drug Discovery: Great Potential and Significant Challenges." Assay and drug development technologies vol. 13,4 (2015): 185. doi: https://doi.org/10.1089/adt.2015.29000.rcu
Cummings R. Epigenetic Drug Discovery: Great Potential and Significant Challenges. Assay Drug Dev Technol. 2015 May;13(4):185. doi: 10.1089/adt.2015.29000.rcu. PMID: 26065555.
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Epigenetic modifier drugs trigger widespread transcription of endogenous retroviruses.

Nature genetics

Mager DL, Lorincz MC.
PMID: 28656984
Nat Genet. 2017 Jun 28;49(7):974-975. doi: 10.1038/ng.3902.

A study in this issue demonstrates that epigenome-modifying drugs used in cancer chemotherapy induce transcription from thousands of previously unannotated transcription start sites, most of which are derived from ancient endogenous retroviruses (ERVs). This work, coupled with previous related...

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Mager DL, Lorincz MC. Epigenetic modifier drugs trigger widespread transcription of endogenous retroviruses. Nat Genet. 2017;49(7):974-975doi: 10.1038/ng.3902.
Mager, D. L., & Lorincz, M. C. (2017). Epigenetic modifier drugs trigger widespread transcription of endogenous retroviruses. Nature genetics, 49(7), 974-975. https://doi.org/10.1038/ng.3902
Mager, Dixie L, and Lorincz, Matthew C. "Epigenetic modifier drugs trigger widespread transcription of endogenous retroviruses." Nature genetics vol. 49,7 (2017): 974-975. doi: https://doi.org/10.1038/ng.3902
Mager DL, Lorincz MC. Epigenetic modifier drugs trigger widespread transcription of endogenous retroviruses. Nat Genet. 2017 Jun 28;49(7):974-975. doi: 10.1038/ng.3902. PMID: 28656984.
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A composite framework for the statistical analysis of epidemiological DNA methylation data with the Infinium Human Methylation 450K BeadChip.

IEEE journal of biomedical and health informatics

Valavanis I, Sifakis EG, Georgiadis P, Kyrtopoulos S, Chatziioannou AA.
PMID: 24808224
IEEE J Biomed Health Inform. 2014 May;18(3):817-23. doi: 10.1109/JBHI.2014.2298351.

High-throughput DNA methylation profiling exploits microarray technologies thus providing a wealth of data, which however solicits rigorous, generic, and analytical pipelines for an efficient systems level analysis and interpretation. In this study, we utilize the Illumina's Infinium Human Methylation...

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Valavanis I, Sifakis EG, Georgiadis P, et al. A composite framework for the statistical analysis of epidemiological DNA methylation data with the Infinium Human Methylation 450K BeadChip. IEEE J Biomed Health Inform. 2014;18(3):817-23doi: 10.1109/JBHI.2014.2298351.
Valavanis, I., Sifakis, E. G., Georgiadis, P., Kyrtopoulos, S., & Chatziioannou, A. A. (2014). A composite framework for the statistical analysis of epidemiological DNA methylation data with the Infinium Human Methylation 450K BeadChip. IEEE journal of biomedical and health informatics, 18(3), 817-23. https://doi.org/10.1109/JBHI.2014.2298351
Valavanis, Ioannis, et al. "A composite framework for the statistical analysis of epidemiological DNA methylation data with the Infinium Human Methylation 450K BeadChip." IEEE journal of biomedical and health informatics vol. 18,3 (2014): 817-23. doi: https://doi.org/10.1109/JBHI.2014.2298351
Valavanis I, Sifakis EG, Georgiadis P, Kyrtopoulos S, Chatziioannou AA. A composite framework for the statistical analysis of epidemiological DNA methylation data with the Infinium Human Methylation 450K BeadChip. IEEE J Biomed Health Inform. 2014 May;18(3):817-23. doi: 10.1109/JBHI.2014.2298351. PMID: 24808224.
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Single nucleotide polymorphisms on DNA methylation microarrays: precautions against confounding.

Epigenomics

Barrow TM, Byun HM.
PMID: 25531251
Epigenomics. 2014;6(6):577-9. doi: 10.2217/epi.14.55.

No abstract available.

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Barrow TM, Byun HM. Single nucleotide polymorphisms on DNA methylation microarrays: precautions against confounding. Epigenomics. 2014;6(6):577-9doi: 10.2217/epi.14.55.
Barrow, T. M., & Byun, H. M. (2014). Single nucleotide polymorphisms on DNA methylation microarrays: precautions against confounding. Epigenomics, 6(6), 577-9. https://doi.org/10.2217/epi.14.55
Barrow, Timothy M, and Byun, Hyang-Min. "Single nucleotide polymorphisms on DNA methylation microarrays: precautions against confounding." Epigenomics vol. 6,6 (2014): 577-9. doi: https://doi.org/10.2217/epi.14.55
Barrow TM, Byun HM. Single nucleotide polymorphisms on DNA methylation microarrays: precautions against confounding. Epigenomics. 2014;6(6):577-9. doi: 10.2217/epi.14.55. PMID: 25531251.
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Facio-scapulo-humeral muscular dystrophy and its connection with facio-scapuloperoneal muscular dystrophy 4q35-linked: some historical remarks.

Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology

[No authors listed]
PMID: 25873785
Acta Myol. 2014 Dec;33(3):152-3.

No abstract available.

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Facio-scapulo-humeral muscular dystrophy and its connection with facio-scapuloperoneal muscular dystrophy 4q35-linked: some historical remarks. Acta Myol. 2014;33(3):152-3
(2014). Facio-scapulo-humeral muscular dystrophy and its connection with facio-scapuloperoneal muscular dystrophy 4q35-linked: some historical remarks. Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology, 33(3), 152-3.
"Facio-scapulo-humeral muscular dystrophy and its connection with facio-scapuloperoneal muscular dystrophy 4q35-linked: some historical remarks." Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology vol. 33,3 (2014): 152-3.
Facio-scapulo-humeral muscular dystrophy and its connection with facio-scapuloperoneal muscular dystrophy 4q35-linked: some historical remarks. Acta Myol. 2014 Dec;33(3):152-3. PMID: 25873785; PMCID: PMC4369846.
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Back to the past in schizophrenia genomics.

Nature neuroscience

Sharp AJ, Akbarian S.
PMID: 26713739
Nat Neurosci. 2016 Jan;19(1):1-2. doi: 10.1038/nn.4203.

No abstract available.

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Sharp AJ, Akbarian S. Back to the past in schizophrenia genomics. Nat Neurosci. 2016;19(1):1-2doi: 10.1038/nn.4203.
Sharp, A. J., & Akbarian, S. (2016). Back to the past in schizophrenia genomics. Nature neuroscience, 19(1), 1-2. https://doi.org/10.1038/nn.4203
Sharp, Andrew J, and Akbarian, Schahram. "Back to the past in schizophrenia genomics." Nature neuroscience vol. 19,1 (2016): 1-2. doi: https://doi.org/10.1038/nn.4203
Sharp AJ, Akbarian S. Back to the past in schizophrenia genomics. Nat Neurosci. 2016 Jan;19(1):1-2. doi: 10.1038/nn.4203. PMID: 26713739.
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Epigenetics and noncommunicable diseases.

Epigenomics

Sharp GC, Relton CL.
PMID: 28523931
Epigenomics. 2017 Jun;9(6):789-791. doi: 10.2217/epi-2017-0045. Epub 2017 May 19.

No abstract available.

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Sharp GC, Relton CL. Epigenetics and noncommunicable diseases. Epigenomics. 2017;9(6):789-791doi: 10.2217/epi-2017-0045.
Sharp, G. C., & Relton, C. L. (2017). Epigenetics and noncommunicable diseases. Epigenomics, 9(6), 789-791. https://doi.org/10.2217/epi-2017-0045
Sharp, Gemma C, and Relton, Caroline L. "Epigenetics and noncommunicable diseases." Epigenomics vol. 9,6 (2017): 789-791. doi: https://doi.org/10.2217/epi-2017-0045
Sharp GC, Relton CL. Epigenetics and noncommunicable diseases. Epigenomics. 2017 Jun;9(6):789-791. doi: 10.2217/epi-2017-0045. Epub 2017 May 19. PMID: 28523931.
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Meeting Report of the Fifth International Cancer Epigenetics Conference in Beijing, China, October 2016.

Epigenomics

Gao D, Herman JG, Cui H, Jen J, Fuks F, Brock MV, Ushijima T, Croce C, Akiyama Y, Guo M.
PMID: 28530839
Epigenomics. 2017 Jul;9(7):937-941. doi: 10.2217/epi-2017-0030. Epub 2017 May 22.

Fifth International Cancer Epigenetics Conference, Beijing, China, 21-23 October 2016 This meeting reported many new findings in the field of cancer epigenetics, including basic science, translational and clinical studies. In this report, we summarize some of the main advancements...

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Gao D, Herman JG, Cui H, et al. Meeting Report of the Fifth International Cancer Epigenetics Conference in Beijing, China, October 2016. Epigenomics. 2017;9(7):937-941doi: 10.2217/epi-2017-0030.
Gao, D., Herman, J. G., Cui, H., Jen, J., Fuks, F., Brock, M. V., Ushijima, T., Croce, C., Akiyama, Y., & Guo, M. (2017). Meeting Report of the Fifth International Cancer Epigenetics Conference in Beijing, China, October 2016. Epigenomics, 9(7), 937-941. https://doi.org/10.2217/epi-2017-0030
Gao, Dan, et al. "Meeting Report of the Fifth International Cancer Epigenetics Conference in Beijing, China, October 2016." Epigenomics vol. 9,7 (2017): 937-941. doi: https://doi.org/10.2217/epi-2017-0030
Gao D, Herman JG, Cui H, Jen J, Fuks F, Brock MV, Ushijima T, Croce C, Akiyama Y, Guo M. Meeting Report of the Fifth International Cancer Epigenetics Conference in Beijing, China, October 2016. Epigenomics. 2017 Jul;9(7):937-941. doi: 10.2217/epi-2017-0030. Epub 2017 May 22. PMID: 28530839.
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Imagining roles for epigenetics in health promotion research.

Journal of behavioral medicine

McBride CM, Koehly LM.
PMID: 27412775
J Behav Med. 2017 Apr;40(2):229-238. doi: 10.1007/s10865-016-9764-4. Epub 2016 Jul 13.

Discoveries from the Human Genome Project have invigorated discussions of epigenetic effects-modifiable chemical processes that influence DNA's ability to give instructions to turn gene expression on or off-on health outcomes. We suggest three domains in which new understandings of...

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McBride CM, Koehly LM. Imagining roles for epigenetics in health promotion research. J Behav Med. 2016;40(2):229-238doi: 10.1007/s10865-016-9764-4.
McBride, C. M., & Koehly, L. M. (2017). Imagining roles for epigenetics in health promotion research. Journal of behavioral medicine, 40(2), 229-238. https://doi.org/10.1007/s10865-016-9764-4
McBride, Colleen M, and Koehly, Laura M. "Imagining roles for epigenetics in health promotion research." Journal of behavioral medicine vol. 40,2 (2017): 229-238. doi: https://doi.org/10.1007/s10865-016-9764-4
McBride CM, Koehly LM. Imagining roles for epigenetics in health promotion research. J Behav Med. 2017 Apr;40(2):229-238. doi: 10.1007/s10865-016-9764-4. Epub 2016 Jul 13. PMID: 27412775; PMCID: PMC5332486.
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Mantle cell lymphoma: report of the 2010 Mantle Cell Lymphoma Consortium Workshop.

Leukemia & lymphoma

Williams ME, Connors JM, Dreyling MH, Gascoyne RD, Kahl BS, Leonard JP, Press OW, Wilson WH.
PMID: 21133727
Leuk Lymphoma. 2011 Jan;52(1):24-33. doi: 10.3109/10428194.2010.532893. Epub 2010 Dec 06.

Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma typically characterized by cyclin D1 overexpression as result of the t(11;14) translocation. MCL is biologically and clinically heterogeneous and frequently involves extranodal dissemination. Although MCL is incurable with current...

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Williams ME, Connors JM, Dreyling MH, et al. Mantle cell lymphoma: report of the 2010 Mantle Cell Lymphoma Consortium Workshop. Leuk Lymphoma. 2010;52(1):24-33doi: 10.3109/10428194.2010.532893.
Williams, M. E., Connors, J. M., Dreyling, M. H., Gascoyne, R. D., Kahl, B. S., Leonard, J. P., Press, O. W., & Wilson, W. H. (2011). Mantle cell lymphoma: report of the 2010 Mantle Cell Lymphoma Consortium Workshop. Leukemia & lymphoma, 52(1), 24-33. https://doi.org/10.3109/10428194.2010.532893
Williams, Michael E, et al. "Mantle cell lymphoma: report of the 2010 Mantle Cell Lymphoma Consortium Workshop." Leukemia & lymphoma vol. 52,1 (2011): 24-33. doi: https://doi.org/10.3109/10428194.2010.532893
Williams ME, Connors JM, Dreyling MH, Gascoyne RD, Kahl BS, Leonard JP, Press OW, Wilson WH. Mantle cell lymphoma: report of the 2010 Mantle Cell Lymphoma Consortium Workshop. Leuk Lymphoma. 2011 Jan;52(1):24-33. doi: 10.3109/10428194.2010.532893. Epub 2010 Dec 06. PMID: 21133727; PMCID: PMC7357185.
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["Atypical" method for understanding dementia. How can studying epigenetics contribute?].

Rinsho shinkeigaku = Clinical neurology

Iwata A.
PMID: 22277421
Rinsho Shinkeigaku. 2011 Nov;51(11):928-9. doi: 10.5692/clinicalneurol.51.928.

The pathological hallmark of neurodegeneration is presence of intra- and extra neuronal inclusion bodies such as Lewy bodies in Parkinson's disease, senile plaques and neurofibrillary tangles in Alzheimer's disease. These are consisted of aggregated conformationally abnormal proteins. The precise...

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Iwata A. ["Atypical" method for understanding dementia. How can studying epigenetics contribute?]. Rinsho Shinkeigaku. 2011;51(11):928-9doi: 10.5692/clinicalneurol.51.928.
Iwata, A. (2011). ["Atypical" method for understanding dementia. How can studying epigenetics contribute?]. Rinsho shinkeigaku = Clinical neurology, 51(11), 928-9. https://doi.org/10.5692/clinicalneurol.51.928
Iwata, Atsushi. "["Atypical" method for understanding dementia. How can studying epigenetics contribute?]." Rinsho shinkeigaku = Clinical neurology vol. 51,11 (2011): 928-9. doi: https://doi.org/10.5692/clinicalneurol.51.928
Iwata A. ["Atypical" method for understanding dementia. How can studying epigenetics contribute?]. Rinsho Shinkeigaku. 2011 Nov;51(11):928-9. doi: 10.5692/clinicalneurol.51.928. Japanese. PMID: 22277421.
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Epigenetics Europe conference. Munich, Germany, 8-9 September 2011.

Epigenomics

Jeltsch A.
PMID: 22126289
Epigenomics. 2011 Dec;3(6):693-5. doi: 10.2217/epi.11.95.

At the Epigenetics Europe conference in Munich, Germany, held on 8-9 September 2011, 19 speakers from different European countries were presenting novel data and concepts on molecular epigenetics. The talks were mainly focused on questions of the generation, maintenance,...

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Jeltsch A. Epigenetics Europe conference. Munich, Germany, 8-9 September 2011. Epigenomics. 2011;3(6):693-5doi: 10.2217/epi.11.95.
Jeltsch, A. (2011). Epigenetics Europe conference. Munich, Germany, 8-9 September 2011. Epigenomics, 3(6), 693-5. https://doi.org/10.2217/epi.11.95
Jeltsch, Albert. "Epigenetics Europe conference. Munich, Germany, 8-9 September 2011." Epigenomics vol. 3,6 (2011): 693-5. doi: https://doi.org/10.2217/epi.11.95
Jeltsch A. Epigenetics Europe conference. Munich, Germany, 8-9 September 2011. Epigenomics. 2011 Dec;3(6):693-5. doi: 10.2217/epi.11.95. PMID: 22126289.
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Showing 1 to 12 of 161 entries