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Showing 1 to 12 of 108 entries
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Gene × environment interactions in type 2 diabetes.

Current diabetes reports

Franks PW.
PMID: 21887612
Curr Diab Rep. 2011 Dec;11(6):552-61. doi: 10.1007/s11892-011-0224-9.

People vary genetically in their susceptibility to the effects of environmental risk factors for many diseases. Genetic variation also underlies the extent to which people respond appropriately to clinical therapies. Defining the basis to the interactions between the genome...

[Fine mapping of complex disease susceptibility loci].

Yi chuan = Hereditas

Song Q, Zhang H, Ma Y, Zhou G.
PMID: 24846913
Yi Chuan. 2014 Jan;36(1):2-10. doi: 10.3724/sp.j.1005.2014.00002.

Genome-wide association studies (GWAS) using single nucleotide polymorphism (SNP) markers have identified more than 3800 susceptibility loci for more than 660 diseases or traits. However, the most significantly associated variants or causative variants in these loci and their biological...

Genetic conditions associated with a predisposition to kidney cancer.

Clinical advances in hematology & oncology : H&O

[No authors listed]
PMID: 28591096
Clin Adv Hematol Oncol. 2017 Apr;15(4):239-241.

No abstract available.

A miRNA-driven inference model to construct potential drug-disease associations for drug repositioning.

BioMed research international

Chen H, Zhang Z.
PMID: 25789319
Biomed Res Int. 2015;2015:406463. doi: 10.1155/2015/406463. Epub 2015 Feb 19.

Increasing evidence discovered that the inappropriate expression of microRNAs (miRNAs) will lead to many kinds of complex diseases and drugs can regulate the expression level of miRNAs. Therefore human diseases may be treated by targeting some specific miRNAs with...

DISEASES: text mining and data integration of disease-gene associations.

Methods (San Diego, Calif.)

Pletscher-Frankild S, Pallejà A, Tsafou K, Binder JX, Jensen LJ.
PMID: 25484339
Methods. 2015 Mar;74:83-9. doi: 10.1016/j.ymeth.2014.11.020. Epub 2014 Dec 05.

Text mining is a flexible technology that can be applied to numerous different tasks in biology and medicine. We present a system for extracting disease-gene associations from biomedical abstracts. The system consists of a highly efficient dictionary-based tagger for...

Major leads in the search for susceptibility genes for depression.

The pharmacogenomics journal

Mitchell PB, Schofield PR, Donald JA.
PMID: 14610522
Pharmacogenomics J. 2003;3(6):305-7. doi: 10.1038/sj.tpj.6500212.

No abstract available.

A strategy for finding susceptibility genes and polymorphisms for COPD.

Experimental lung research

Paré P.
PMID: 16395865
Exp Lung Res. 2005 Sep;31:76.

No abstract available.

Exploring genetic susceptibility to cancer in diverse populations.

Current opinion in genetics & development

Haiman CA, Stram DO.
PMID: 20359883
Curr Opin Genet Dev. 2010 Jun;20(3):330-5. doi: 10.1016/j.gde.2010.02.007. Epub 2010 Mar 30.

Incidence rates for many cancers differ markedly by race/ethnicity and furthering our understanding of the genetic and environmental causes of such disparities is a scientific and public health need. Genome-wide association studies (GWAS) are widely acknowledged to provide important...

[Atrophic age-related macular degeneration].

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft

von Strachwitz CN.
PMID: 23783997
Ophthalmologe. 2013 Jun;110(6):555-65; quiz 566-7. doi: 10.1007/s00347-012-2757-y.

Atrophic age-related macular degeneration (AMD) is a degenerative disorder of the central retina that greatly increases with age. This complex disease is mainly based on a genetic background but environmental factors are most likely responsible for modulating the individual...

De novo mutation in schizophrenia.

Schizophrenia bulletin

Rees E, Kirov G, O'Donovan MC, Owen MJ.
PMID: 22451492
Schizophr Bull. 2012 May;38(3):377-81. doi: 10.1093/schbul/sbs047. Epub 2012 Mar 26.

Several studies in the last 5 years have shown that newly arising (de novo) mutations contribute to the genetics of schizophrenia (SZ). This will replenish genetic variants removed by natural selection and could, in part, explain why SZ prevalence...

Systematic prioritization and integrative analysis of copy number variations in schizophrenia reveal key schizophrenia susceptibility genes.

Schizophrenia bulletin

Luo X, Huang L, Han L, Luo Z, Hu F, Tieu R, Gan L.
PMID: 24664977
Schizophr Bull. 2014 Nov;40(6):1285-99. doi: 10.1093/schbul/sbu045. Epub 2014 Mar 24.

Schizophrenia is a common mental disorder with high heritability and strong genetic heterogeneity. Common disease-common variants hypothesis predicts that schizophrenia is attributable in part to common genetic variants. However, recent studies have clearly demonstrated that copy number variations (CNVs)...

[Genetic susceptibility to type 1 diabetes].

Nihon rinsho. Japanese journal of clinical medicine

Babaya N, Ikegami H.
PMID: 22768543
Nihon Rinsho. 2012 May;70:337-41.

No abstract available.

Showing 1 to 12 of 108 entries