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Comparability of mixed IC₅₀ data - a statistical analysis.

PloS one

Kalliokoski T, Kramer C, Vulpetti A, Gedeck P.
PMID: 23613770
PLoS One. 2013 Apr 16;8(4):e61007. doi: 10.1371/journal.pone.0061007. Print 2013.

The biochemical half maximal inhibitory concentration (IC50) is the most commonly used metric for on-target activity in lead optimization. It is used to guide lead optimization, build large-scale chemogenomics analysis, off-target activity and toxicity models based on public data....

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Kalliokoski T, Kramer C, Vulpetti A, et al. Comparability of mixed IC₅₀ data - a statistical analysis. PLoS One. 2013;8(4):e61007doi: 10.1371/journal.pone.0061007.
Kalliokoski, T., Kramer, C., Vulpetti, A., & Gedeck, P. (2013). Comparability of mixed IC₅₀ data - a statistical analysis. PloS one, 8(4), e61007. https://doi.org/10.1371/journal.pone.0061007
Kalliokoski, Tuomo, et al. "Comparability of mixed IC₅₀ data - a statistical analysis." PloS one vol. 8,4 (2013): e61007. doi: https://doi.org/10.1371/journal.pone.0061007
Kalliokoski T, Kramer C, Vulpetti A, Gedeck P. Comparability of mixed IC₅₀ data - a statistical analysis. PLoS One. 2013 Apr 16;8(4):e61007. doi: 10.1371/journal.pone.0061007. Print 2013. PMID: 23613770; PMCID: PMC3628986.
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ICECAP: an integrated, general-purpose, automation-assisted IC50/EC50 assay platform.

Journal of laboratory automation

Li M, Chou J, King KW, Jing J, Wei D, Yang L.
PMID: 25524493
J Lab Autom. 2015 Feb;20(1):32-45. doi: 10.1177/2211068214562449. Epub 2014 Dec 18.

BACKGROUND: IC50 and EC50 values are commonly used to evaluate drug potency. Mass spectrometry (MS)-centric bioanalytical and biomarker labs are now conducting IC50/EC50 assays, which, if done manually, are tedious and error-prone. Existing bioanalytical sample preparation automation systems cannot...

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Li M, Chou J, King KW, et al. ICECAP: an integrated, general-purpose, automation-assisted IC50/EC50 assay platform. J Lab Autom. 2014;20(1):32-45doi: 10.1177/2211068214562449.
Li, M., Chou, J., King, K. W., Jing, J., Wei, D., & Yang, L. (2015). ICECAP: an integrated, general-purpose, automation-assisted IC50/EC50 assay platform. Journal of laboratory automation, 20(1), 32-45. https://doi.org/10.1177/2211068214562449
Li, Ming, et al. "ICECAP: an integrated, general-purpose, automation-assisted IC50/EC50 assay platform." Journal of laboratory automation vol. 20,1 (2015): 32-45. doi: https://doi.org/10.1177/2211068214562449
Li M, Chou J, King KW, Jing J, Wei D, Yang L. ICECAP: an integrated, general-purpose, automation-assisted IC50/EC50 assay platform. J Lab Autom. 2015 Feb;20(1):32-45. doi: 10.1177/2211068214562449. Epub 2014 Dec 18. PMID: 25524493.
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Methods of estimation of IC50 and SC50 parameters for indirect response models from single dose data.

Journal of pharmaceutical sciences

Wyska E, Mager DE, Krzyzanski W.
PMID: 12820148
J Pharm Sci. 2003 Jul;92(7):1438-54. doi: 10.1002/jps.10407.

The basic indirect response models are described by several pharmacodynamic parameters of which IC(50) (drug concentration eliciting 50% of the maximum inhibition) and SC(50) (drug concentration eliciting 50% of the maximum stimulation) are not readily derived from the response...

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Wyska E, Mager DE, Krzyzanski W. Methods of estimation of IC50 and SC50 parameters for indirect response models from single dose data. J Pharm Sci. 2003;92(7):1438-54doi: 10.1002/jps.10407.
Wyska, E., Mager, D. E., & Krzyzanski, W. (2003). Methods of estimation of IC50 and SC50 parameters for indirect response models from single dose data. Journal of pharmaceutical sciences, 92(7), 1438-54. https://doi.org/10.1002/jps.10407
Wyska, Elzbieta, et al. "Methods of estimation of IC50 and SC50 parameters for indirect response models from single dose data." Journal of pharmaceutical sciences vol. 92,7 (2003): 1438-54. doi: https://doi.org/10.1002/jps.10407
Wyska E, Mager DE, Krzyzanski W. Methods of estimation of IC50 and SC50 parameters for indirect response models from single dose data. J Pharm Sci. 2003 Jul;92(7):1438-54. doi: 10.1002/jps.10407. PMID: 12820148.
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Showing 1 to 3 of 3 entries