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Showing 1 to 12 of 30 entries
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The familial nature of MS.

Neurology

Sadovnick AD.
PMID: 6681553
Neurology. 1983 Jan;33(1):117. doi: 10.1212/wnl.33.1.117.

No abstract available.

The familial nature of multiple sclerosis: empiric recurrence risks for first, second-, and third-degree relatives of patients.

Neurology

Sadovnick AD, Macleod PM.
PMID: 7196517
Neurology. 1981 Aug;31(8):1039-41. doi: 10.1212/wnl.31.8.1039.

Although the risks are low, relatives of multiple sclerosis (MS) patients have a greater risk of developing the disease than the general population. Since this is true of second- and third-degree relatives as well as first-degree relatives, the increased...

Current concepts in multiple sclerosis: Part I.

South Dakota journal of medicine

Hanson LJ, Cafruny WA.
PMID: 12422797
S D J Med. 2002 Oct;55(10):433-6.

Multiple sclerosis (MS) is a complex and challenging autoimmune disease of the central nervous system, affecting approximately 0.1% of the US population. Evidence to date suggests that viral infection triggers autoimmune attack against nerve cells in genetically-susceptible individuals. Neurologic...

The genetics of multiple sclerosis.

Journal of neurovirology

Compston A.
PMID: 10871776
J Neurovirol. 2000 May;6:S5-9.

Epidemiological studies implicate an interplay between genetic and environmental factors in the aetiology of multiple sclerosis. The classical genetic observations suggest that multiple sclerosis is a complex trait in which susceptibility is determined by several genes acting independently or...

An insight about genomic susceptibility & multiple sclerosis.

The Indian journal of medical research

Verma R, Singh N.
PMID: 29067970
Indian J Med Res. 2017 Jun;145(6):713-714. doi: 10.4103/ijmr.IJMR_725_17.

No abstract available.

NR1H3 p.Arg415Gln Is Not Associated to Multiple Sclerosis Risk.

Neuron

[No authors listed]
PMID: 27764667
Neuron. 2016 Oct 19;92(2):333-335. doi: 10.1016/j.neuron.2016.09.052.

A recent study by Wang et al. (2016a) claims that the low-frequency variant NR1H3 p.Arg415Gln is sufficient to cause multiple sclerosis in certain individuals and determines a patient's likelihood of primary progressive disease. We sought to replicate this finding...

The epidemiology of multiple sclerosis.

Acta neurologica Scandinavica. Supplementum

Martyn CN, Gale CR.
PMID: 9174634
Acta Neurol Scand Suppl. 1997;169:3-7. doi: 10.1111/j.1600-0404.1997.tb08143.x.

No abstract available.

The role of epidemiology in MS research: Past successes, current challenges and future potential.

Multiple sclerosis (Houndmills, Basingstoke, England)

Simpson S, Taylor BV, van der Mei I.
PMID: 25767125
Mult Scler. 2015 Jul;21(8):969-77. doi: 10.1177/1352458515574896. Epub 2015 Mar 12.

Multiple sclerosis (MS) is a multifaceted condition, with a range of environmental, behavioural and genetic factors implicated in its aetiology and clinical course. Successes in advancing our appreciation of the roles of Epstein-Barr virus, vitamin D/UV and the HLA-DRB1...

Genome-wide association studies: will we ever predict susceptibility to multiple sclerosis through genetics?.

Expert review of neurotherapeutics

Dobson R, Ramagopalan SV, Giovannoni G.
PMID: 23448211
Expert Rev Neurother. 2013 Mar;13(3):235-7. doi: 10.1586/ern.13.13.

No abstract available.

Multiple sclerosis genetics.

Multiple sclerosis (Houndmills, Basingstoke, England)

Canto E, Oksenberg JR.
PMID: 29307290
Mult Scler. 2018 Jan;24(1):75-79. doi: 10.1177/1352458517737371.

A broad scientific consensus has emerged linking multiple sclerosis (MS) risk to multiple independent and interacting DNA variants that are relatively frequent in the population and act in concert with environmental exposures. The multifactorial, polygenic model of heritability provided...

How do we measure the epigenome(s)?.

Multiple sclerosis (Houndmills, Basingstoke, England)

Klein HU, De Jager PL.
PMID: 29722595
Mult Scler. 2018 Apr;24(4):446-448. doi: 10.1177/1352458517750772.

No abstract available.

Evaluating the role of genetic variation in the epigenome in health and disease.

Multiple sclerosis (Houndmills, Basingstoke, England)

Roostaei T, De Jager PL.
PMID: 29790436
Mult Scler. 2018 May;24(6):707-709. doi: 10.1177/1352458517751651.

No abstract available.

Showing 1 to 12 of 30 entries