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Overview of the BioCreative VI Precision Medicine Track: mining protein interactions and mutations for precision medicine.

Database : the journal of biological databases and curation

Islamaj Dogan R, Kim S, Chatr-Aryamontri A, Wei CH, Comeau DC, Antunes R, Matos S, Chen Q, Elangovan A, Panyam NC, Verspoor K, Liu H, Wang Y, Liu Z, Altinel B, Hüsünbeyi ZM, Özgür A, Fergadis A, Wang CK, Dai HJ, Tran T, Kavuluru R, Luo L, Steppi A, Zhang J, Qu J, Lu Z.
PMID: 30689846
Database (Oxford). 2019 Jan 01;2019. doi: 10.1093/database/bay147.

The Precision Medicine Initiative is a multicenter effort aiming at formulating personalized treatments leveraging on individual patient data (clinical, genome sequence and functional genomic data) together with the information in large knowledge bases (KBs) that integrate genome annotation, disease...

Evolutionary dynamics of carcinogenesis and why targeted therapy does not work.

Nature reviews. Cancer

Gillies RJ, Verduzco D, Gatenby RA.
PMID: 22695393
Nat Rev Cancer. 2012 Jun 14;12(7):487-93. doi: 10.1038/nrc3298.

All malignant cancers, whether inherited or sporadic, are fundamentally governed by Darwinian dynamics. The process of carcinogenesis requires genetic instability and highly selective local microenvironments, the combination of which promotes somatic evolution. These microenvironmental forces, specifically hypoxia, acidosis and...

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