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Showing 1 to 4 of 4 entries
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Regulation of LRRK2: insights from structural and biochemical analysis.

Biological chemistry

Gilsbach BK, Eckert M, Gloeckner CJ.
PMID: 29894291
Biol Chem. 2018 Jun 27;399(7):637-642. doi: 10.1515/hsz-2018-0132.

Leucine-rich repeat kinase 2 (LRRK2) is a multi-domain protein and its mutations can lead to Parkinson's disease. Recent studies on LRRK2 and homologue proteins have advanced our mechanistic understanding of LRRK2 regulation. Here, we summarize the available data on...

Exosomes in Parkinson's Disease.

Neuroscience bulletin

Wu X, Zheng T, Zhang B.
PMID: 28025780
Neurosci Bull. 2017 Jun;33(3):331-338. doi: 10.1007/s12264-016-0092-z. Epub 2016 Dec 26.

Exosomes, nano-sized extracellular vesicles secreted by most cell types, are found in all kinds of biological fluids and tissues, including the central nervous system (CNS). The proposed functions of these vesicles include roles in cell-cell signaling, removal of cellular...

Apathy in Parkinson's Disease.

International review of neurobiology

Pagonabarraga J, Kulisevsky J.
PMID: 28802937
Int Rev Neurobiol. 2017;133:657-678. doi: 10.1016/bs.irn.2017.05.025. Epub 2017 Jul 10.

The normal maintenance of human motivation depends on the integrity of subcortical structures that link the medial and lateral prefrontal cortex with the limbic system. Apathy is highly prevalent in Parkinson's disease and causes major impact on the quality...

How close are we to revealing the etiology of Parkinson's disease?.

Expert review of neurotherapeutics

Jellinger KA.
PMID: 26294223
Expert Rev Neurother. 2015 Oct;15(10):1105-7. doi: 10.1586/14737175.2015.1079486. Epub 2015 Aug 17.

No abstract available.

Showing 1 to 4 of 4 entries