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Showing 1 to 12 of 12 entries
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The clinical value of FDA class C drugs approved from 1981 to 1988.

Clinical pharmacology and therapeutics

Yasuda SU, Woosley RL.
PMID: 1458766
Clin Pharmacol Ther. 1992 Dec;52(6):577-82. doi: 10.1038/clpt.1992.194.

No abstract available.

[Classification and pharmacotherapeutic coding of drugs].

Pharmaceutisch weekblad

de Ru H.
PMID: 4654264
Pharm Weekbl. 1972 Dec 01;107(48):745-62.

No abstract available.

Soft drug design: general principles and recent applications.

Medicinal research reviews

Bodor N, Buchwald P.
PMID: 10608921
Med Res Rev. 2000 Jan;20(1):58-101. doi: 10.1002/(sici)1098-1128(200001)20:1<58::aid-med3>3.0.co;2-x.

Soft drug design represents a new approach aimed to design safer drugs with an increased therapeutic index by integrating metabolism considerations into the drug design process. Soft drugs are new therapeutic agents that undergo predictable metabolism to inactive metabolites...

[The new classification of drugs: the ATC-code now introduced].

Ugeskrift for laeger

[No authors listed]
PMID: 7233607
Ugeskr Laeger. 1981 Apr 13;143(16):1037-9.

No abstract available.

Convolutional Neural Networks for ATC Classification.

Current pharmaceutical design

Lumini A, Nanni L.
PMID: 30417778
Curr Pharm Des. 2018;24(34):4007-4012. doi: 10.2174/1381612824666181112113438.

BACKGROUND: Anatomical Therapeutic Chemical (ATC) classification of unknown compound has raised high significance for both drug development and basic research. The ATC system is a multi-label classification system proposed by the World Health Organization (WHO), which categorizes drugs into...

Data science-driven analyses of drugs inducing hypertension as an adverse effect.

Molecular diversity

Sharma R.
PMID: 32415493
Mol Divers. 2021 May;25(2):801-810. doi: 10.1007/s11030-020-10059-5. Epub 2020 May 15.

The utilization of approved medication is a requisite to combat certain diseases for health; however, the undesirable adverse effects (AEs) due to medication are generally unavoidable. Hypertension is one of such AEs resulting from approved medication in which blood...

[Classification of drugs by biochemical mechanism of action].

Voprosy meditsinskoi khimii

Kulinskiĭ LS, Kolesnichenko LS.
PMID: 9634721
Vopr Med Khim. 1998 Mar-Apr;44(2):179-84.

Biochemical drugs classification is proposed. Drugs are divided into 6 classes, according to their action on: 1) signal-transduction systems, 2) other components of plasmatic membranes, 3) intracellularly, 4) gene therapy, 5) extracellularly, 6) invasive agents. Concrete biochemical mechanisms of...

Influence of HPLC retention data and molecular modeling descriptors on prediction of pharmacological classification of drugs using principal component analysis method.

Combinatorial chemistry & high throughput screening

Koba M, Bober L, Judycka-Proma U, Baczek T.
PMID: 20615199
Comb Chem High Throughput Screen. 2010 Nov;13(9):765-76. doi: 10.2174/138620710792927411.

The usage of principal component analysis (PCA) method in prediction of pharmacological classification of the drugs based on high-performance liquid chromatography (HPLC) retention data and on non-empirical structural parameters was studied. A group of 36 drugs of established pharmacological...

Synthetic approaches to the 2006 new drugs.

Mini reviews in medicinal chemistry

Liu KK, Sakya SM, Li J.
PMID: 18220978
Mini Rev Med Chem. 2007 Dec;7(12):1255-69. doi: 10.2174/138955707782795629.

New drugs are introduced to the market every year and each individual drug represents a privileged structure for its biological target. In addition, these new chemical entities (NCEs) not only provide insights into molecular recognition, but also serve as...

Metabolic profiling using HPLC allows classification of drugs according to their mechanisms of action in HL-1 cardiomyocytes.

Toxicology and applied pharmacology

Strigun A, Wahrheit J, Beckers S, Heinzle E, Noor F.
PMID: 21320520
Toxicol Appl Pharmacol. 2011 Apr 15;252(2):183-91. doi: 10.1016/j.taap.2011.02.008. Epub 2011 Feb 12.

Along with hepatotoxicity, cardiotoxic side effects remain one of the major reasons for drug withdrawals and boxed warnings. Prediction methods for cardiotoxicity are insufficient. High content screening comprising of not only electrophysiological characterization but also cellular molecular alterations are...

Most prescribed pharmaceuticals.

Modern healthcare

[No authors listed]
PMID: 24044238
Mod Healthc. 2013 Jul 15;43(28):34.

No abstract available.

Seven therapeutic categories account for most drug cost increases.

Managed care (Langhorne, Pa.)

[No authors listed]
PMID: 22259880
Manag Care. 2011 Dec;20(12):69.

No abstract available.

Showing 1 to 12 of 12 entries