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Serum alanine aminotransferase as a biomarker of treatment response in nonalcoholic steatohepatitis.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Loomba R.
PMID: 24703861
Clin Gastroenterol Hepatol. 2014 Oct;12(10):1731-2. doi: 10.1016/j.cgh.2014.03.026. Epub 2014 Apr 01.

No abstract available.

NASH: the tribulations of conducting NASH trials.

Nature reviews. Gastroenterology & hepatology

Neuschwander-Tetri BA.
PMID: 24709815
Nat Rev Gastroenterol Hepatol. 2014 May;11(5):274-6. doi: 10.1038/nrgastro.2014.51. Epub 2014 Apr 08.

Designing clinical trials for the treatment of NASH is challenging. The pathogenesis of this disease is poorly understood and is probably multifactorial. A trial of a phosphodiesterase-4 inhibitor produced negative results, despite promising preclinical data. Examining why this trial...

The discovery, complex crystal structure, and recognition mechanism of a novel natural PDE4 inhibitor from Selaginella pulvinata.

Biochemical pharmacology

Huang Y, Liu X, Wu D, Tang G, Lai Z, Zheng X, Yin S, Luo HB.
PMID: 28159622
Biochem Pharmacol. 2017 Apr 15;130:51-59. doi: 10.1016/j.bcp.2017.01.016. Epub 2017 Jan 31.

Phosphodiesterase-4 (PDE4) is an important drug target for treatment of inflammation-related diseases. Till now, natural PDE4 inhibitors are rare and their co-crystal structures with PDE4 are hardly available. In the present study, selaginpulvilins K and L (1 and 2),...

Showing 1 to 3 of 3 entries