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Quantitative Structure-Activity Relationship for High Affinity 5-HT1A Receptor Ligands Based on Norm Indexes.

The journal of physical chemistry. B

Jia Q, Cui X, Li L, Wang Q, Liu Y, Xia S, Ma P.
PMID: 26605982
J Phys Chem B. 2015 Dec 24;119(51):15561-7. doi: 10.1021/acs.jpcb.5b08980. Epub 2015 Dec 10.

Arylpiperazine derivatives are promising 5-hydroxytryptamine (5-HT) receptor ligands which can inhibit serotonin reuptake effectively. In this work, some norm index descriptors were proposed and further utilized to develop a model for predicting 5-HT1A receptor affinity (pKi) of 88 arylpiperazine...

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