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The life cycle of cancer-associated fibroblasts within the tumour stroma and its importance in disease outcome.

British journal of cancer

D'Arcangelo E, Wu NC, Cadavid JL, McGuigan AP.
PMID: 31992854
Br J Cancer. 2020 Mar;122(7):931-942. doi: 10.1038/s41416-019-0705-1. Epub 2020 Jan 29.

The tumour microenvironment (TME) determines vital aspects of tumour development, such as tumour growth, metastases and response to therapy. Cancer-associated fibroblasts (CAFs) are abundant and extremely influential in this process and interact with cellular and matrix TME constituents such...

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D'Arcangelo E, Wu NC, Cadavid JL, et al. The life cycle of cancer-associated fibroblasts within the tumour stroma and its importance in disease outcome. Br J Cancer. 2020;122(7):931-942doi: 10.1038/s41416-019-0705-1.
D'Arcangelo, E., Wu, N. C., Cadavid, J. L., & McGuigan, A. P. (2020). The life cycle of cancer-associated fibroblasts within the tumour stroma and its importance in disease outcome. British journal of cancer, 122(7), 931-942. https://doi.org/10.1038/s41416-019-0705-1
D'Arcangelo, Elisa, et al. "The life cycle of cancer-associated fibroblasts within the tumour stroma and its importance in disease outcome." British journal of cancer vol. 122,7 (2020): 931-942. doi: https://doi.org/10.1038/s41416-019-0705-1
D'Arcangelo E, Wu NC, Cadavid JL, McGuigan AP. The life cycle of cancer-associated fibroblasts within the tumour stroma and its importance in disease outcome. Br J Cancer. 2020 Mar;122(7):931-942. doi: 10.1038/s41416-019-0705-1. Epub 2020 Jan 29. PMID: 31992854; PMCID: PMC7109057.
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Identification of pyroptosis-related subtypes, the development of a prognosis model, and characterization of tumor microenvironment infiltration in colorectal cancer.

Oncoimmunology

Song W, Ren J, Xiang R, Kong C, Fu T.
PMID: 34676149
Oncoimmunology. 2021 Oct 12;10(1):1987636. doi: 10.1080/2162402X.2021.1987636. eCollection 2021.

Pyroptosis is a newly discovered programmed cell death that is associated with tumor progression, prognosis, and treatment response. However, the potential roles of pyroptosis-related genes (PRGs) in the tumor microenvironment (TME) remain unclear. We described the alterations of PRGs...

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Song W, Ren J, Xiang R, et al. Identification of pyroptosis-related subtypes, the development of a prognosis model, and characterization of tumor microenvironment infiltration in colorectal cancer. Oncoimmunology. 2021;10(1):1987636doi: 10.1080/2162402X.2021.1987636.
Song, W., Ren, J., Xiang, R., Kong, C., & Fu, T. (2021). Identification of pyroptosis-related subtypes, the development of a prognosis model, and characterization of tumor microenvironment infiltration in colorectal cancer. Oncoimmunology, 10(1), 1987636. https://doi.org/10.1080/2162402X.2021.1987636
Song, Wei, et al. "Identification of pyroptosis-related subtypes, the development of a prognosis model, and characterization of tumor microenvironment infiltration in colorectal cancer." Oncoimmunology vol. 10,1 (2021): 1987636. doi: https://doi.org/10.1080/2162402X.2021.1987636
Song W, Ren J, Xiang R, Kong C, Fu T. Identification of pyroptosis-related subtypes, the development of a prognosis model, and characterization of tumor microenvironment infiltration in colorectal cancer. Oncoimmunology. 2021 Oct 12;10(1):1987636. doi: 10.1080/2162402X.2021.1987636. eCollection 2021. PMID: 34676149; PMCID: PMC8526024.
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Intratumor heterogeneity: origins, clinical significance and optimal strategies for cancer treatment.

Future oncology (London, England)

Mangano A, Lianos GD, Mangano A, Boni L, Dionigi G.
PMID: 25686113
Future Oncol. 2015;11(4):561-4. doi: 10.2217/fon.14.296.

No abstract available.

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Mangano A, Lianos GD, Mangano A, et al. Intratumor heterogeneity: origins, clinical significance and optimal strategies for cancer treatment. Future Oncol. 2015;11(4):561-4doi: 10.2217/fon.14.296.
Mangano, A., Lianos, G. D., Mangano, A., Boni, L., & Dionigi, G. (2015). Intratumor heterogeneity: origins, clinical significance and optimal strategies for cancer treatment. Future oncology (London, England), 11(4), 561-4. https://doi.org/10.2217/fon.14.296
Mangano, Alberto, et al. "Intratumor heterogeneity: origins, clinical significance and optimal strategies for cancer treatment." Future oncology (London, England) vol. 11,4 (2015): 561-4. doi: https://doi.org/10.2217/fon.14.296
Mangano A, Lianos GD, Mangano A, Boni L, Dionigi G. Intratumor heterogeneity: origins, clinical significance and optimal strategies for cancer treatment. Future Oncol. 2015;11(4):561-4. doi: 10.2217/fon.14.296. PMID: 25686113.
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The microsatellite instable subset of colorectal cancer is a particularly good candidate for checkpoint blockade immunotherapy.

Cancer discovery

Xiao Y, Freeman GJ.
PMID: 25583798
Cancer Discov. 2015 Jan;5(1):16-8. doi: 10.1158/2159-8290.CD-14-1397.

The microsatellite instable (MSI) subset of colorectal cancer exhibits an active Th1/CTL immune microenvironment, probably due to recognition of a high number of tumor neoantigens. However, the high expression of checkpoint molecules PD-1, PD-L1, CTLA-4, LAG-3, and IDO in...

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Xiao Y, Freeman GJ. The microsatellite instable subset of colorectal cancer is a particularly good candidate for checkpoint blockade immunotherapy. Cancer Discov. 2015;5(1):16-8doi: 10.1158/2159-8290.CD-14-1397.
Xiao, Y., & Freeman, G. J. (2015). The microsatellite instable subset of colorectal cancer is a particularly good candidate for checkpoint blockade immunotherapy. Cancer discovery, 5(1), 16-8. https://doi.org/10.1158/2159-8290.CD-14-1397
Xiao, Yanping, and Freeman, Gordon J. "The microsatellite instable subset of colorectal cancer is a particularly good candidate for checkpoint blockade immunotherapy." Cancer discovery vol. 5,1 (2015): 16-8. doi: https://doi.org/10.1158/2159-8290.CD-14-1397
Xiao Y, Freeman GJ. The microsatellite instable subset of colorectal cancer is a particularly good candidate for checkpoint blockade immunotherapy. Cancer Discov. 2015 Jan;5(1):16-8. doi: 10.1158/2159-8290.CD-14-1397. PMID: 25583798; PMCID: PMC4295637.
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Tumor Microenvironment in Gene Signatures: Critical Biology or Confounding Noise?.

Clinical cancer research : an official journal of the American Association for Cancer Research

Morris JS, Kopetz S.
PMID: 27334836
Clin Cancer Res. 2016 Aug 15;22(16):3989-91. doi: 10.1158/1078-0432.CCR-16-1044. Epub 2016 Jun 22.

The tumor microenvironment contributes important information in gene expression signatures but may be susceptible to sampling variance. Mesenchymal signatures in particular may be influenced by sampling of nonrepresentative regions with high stromal content. Appropriate pathology quality control is required...

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Morris JS, Kopetz S. Tumor Microenvironment in Gene Signatures: Critical Biology or Confounding Noise?. Clin Cancer Res. 2016;22(16):3989-91doi: 10.1158/1078-0432.CCR-16-1044.
Morris, J. S., & Kopetz, S. (2016). Tumor Microenvironment in Gene Signatures: Critical Biology or Confounding Noise?. Clinical cancer research : an official journal of the American Association for Cancer Research, 22(16), 3989-91. https://doi.org/10.1158/1078-0432.CCR-16-1044
Morris, Jeffrey S, and Kopetz, Scott. "Tumor Microenvironment in Gene Signatures: Critical Biology or Confounding Noise?." Clinical cancer research : an official journal of the American Association for Cancer Research vol. 22,16 (2016): 3989-91. doi: https://doi.org/10.1158/1078-0432.CCR-16-1044
Morris JS, Kopetz S. Tumor Microenvironment in Gene Signatures: Critical Biology or Confounding Noise?. Clin Cancer Res. 2016 Aug 15;22(16):3989-91. doi: 10.1158/1078-0432.CCR-16-1044. Epub 2016 Jun 22. PMID: 27334836; PMCID: PMC4987158.
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Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy.

Cancer discovery

Fendt SM, Frezza C, Erez A.
PMID: 33139243
Cancer Discov. 2020 Dec;10(12):1797-1807. doi: 10.1158/2159-8290.CD-20-0844. Epub 2020 Nov 02.

Cancer cells continuously rewire their metabolism to fulfill their need for rapid growth and survival while subject to changes in environmental cues. Thus, a vital component of a cancer cell lies in its metabolic adaptability. The constant demand for...

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Fendt SM, Frezza C, Erez A. Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy. Cancer Discov. 2020;10(12):1797-1807doi: 10.1158/2159-8290.CD-20-0844.
Fendt, S. M., Frezza, C., & Erez, A. (2020). Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy. Cancer discovery, 10(12), 1797-1807. https://doi.org/10.1158/2159-8290.CD-20-0844
Fendt, Sarah-Maria, et al. "Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy." Cancer discovery vol. 10,12 (2020): 1797-1807. doi: https://doi.org/10.1158/2159-8290.CD-20-0844
Fendt SM, Frezza C, Erez A. Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy. Cancer Discov. 2020 Dec;10(12):1797-1807. doi: 10.1158/2159-8290.CD-20-0844. Epub 2020 Nov 02. PMID: 33139243; PMCID: PMC7710573.
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Epigenetic modulation of the tumor microenvironment in head and neck cancer: Challenges and opportunities.

Critical reviews in oncology/hematology

Dos Santos ES, Wagner VP, Cabral Ramos J, Lambert DW, Castilho RM, Paes Leme AF, Chen TS.
PMID: 34146679
Crit Rev Oncol Hematol. 2021 Aug;164:103397. doi: 10.1016/j.critrevonc.2021.103397. Epub 2021 Jun 17.

Head and neck cancer is globally challenging due to the resistance to therapy and aggressive behavior leading to high rates of mortality. Recent findings show that the tumor microenvironment plays a role in the maintenance and progression of many...

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Dos Santos ES, Wagner VP, Cabral Ramos J, et al. Epigenetic modulation of the tumor microenvironment in head and neck cancer: Challenges and opportunities. Crit Rev Oncol Hematol. 2021;164:103397doi: 10.1016/j.critrevonc.2021.103397.
Dos Santos, E. S., Wagner, V. P., Cabral Ramos, J., Lambert, D. W., Castilho, R. M., Paes Leme, A. F., & Chen, T. S. (2021). Epigenetic modulation of the tumor microenvironment in head and neck cancer: Challenges and opportunities. Critical reviews in oncology/hematology, 164103397. https://doi.org/10.1016/j.critrevonc.2021.103397
Dos Santos, Erison Santana, et al. "Epigenetic modulation of the tumor microenvironment in head and neck cancer: Challenges and opportunities." Critical reviews in oncology/hematology vol. 164 (2021): 103397. doi: https://doi.org/10.1016/j.critrevonc.2021.103397
Dos Santos ES, Wagner VP, Cabral Ramos J, Lambert DW, Castilho RM, Paes Leme AF, Chen TS. Epigenetic modulation of the tumor microenvironment in head and neck cancer: Challenges and opportunities. Crit Rev Oncol Hematol. 2021 Aug;164:103397. doi: 10.1016/j.critrevonc.2021.103397. Epub 2021 Jun 17. PMID: 34146679.
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Cancer: a mirrored room between tumor bulk and tumor microenvironment.

Journal of experimental & clinical cancer research : CR

Hernández-Camarero P, López-Ruiz E, Marchal JA, Perán M.
PMID: 34183054
J Exp Clin Cancer Res. 2021 Jun 28;40(1):217. doi: 10.1186/s13046-021-02022-5.

It has been well documented that the tumor microenvironment (TME) plays a key role in the promotion of drug resistance, the support of tumor progression, invasiveness, metastasis, and even the maintenance of a cancer stem-like phenotype. Here, we reviewed...

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Hernández-Camarero P, López-Ruiz E, Marchal JA, et al. Cancer: a mirrored room between tumor bulk and tumor microenvironment. J Exp Clin Cancer Res. 2021;40(1):217doi: 10.1186/s13046-021-02022-5.
Hernández-Camarero, P., López-Ruiz, E., Marchal, J. A., & Perán, M. (2021). Cancer: a mirrored room between tumor bulk and tumor microenvironment. Journal of experimental & clinical cancer research : CR, 40(1), 217. https://doi.org/10.1186/s13046-021-02022-5
Hernández-Camarero, Pablo, et al. "Cancer: a mirrored room between tumor bulk and tumor microenvironment." Journal of experimental & clinical cancer research : CR vol. 40,1 (2021): 217. doi: https://doi.org/10.1186/s13046-021-02022-5
Hernández-Camarero P, López-Ruiz E, Marchal JA, Perán M. Cancer: a mirrored room between tumor bulk and tumor microenvironment. J Exp Clin Cancer Res. 2021 Jun 28;40(1):217. doi: 10.1186/s13046-021-02022-5. PMID: 34183054; PMCID: PMC8240272.
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The tumor microenvironment and cancer.

BioMed research international

Chen Z, Meng Z, Jia L, Cui R.
PMID: 25587537
Biomed Res Int. 2014;2014:573947. doi: 10.1155/2014/573947. Epub 2014 Dec 22.

No abstract available.

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Chen Z, Meng Z, Jia L, et al. The tumor microenvironment and cancer. Biomed Res Int. 2014;2014:573947doi: 10.1155/2014/573947.
Chen, Z., Meng, Z., Jia, L., & Cui, R. (2014). The tumor microenvironment and cancer. BioMed research international, 2014573947. https://doi.org/10.1155/2014/573947
Chen, Zhen, et al. "The tumor microenvironment and cancer." BioMed research international vol. 2014 (2014): 573947. doi: https://doi.org/10.1155/2014/573947
Chen Z, Meng Z, Jia L, Cui R. The tumor microenvironment and cancer. Biomed Res Int. 2014;2014:573947. doi: 10.1155/2014/573947. Epub 2014 Dec 22. PMID: 25587537; PMCID: PMC4284971.
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Nanomotors Sense Local Physicochemical Heterogeneities in Tumor Microenvironments*.

Angewandte Chemie (International ed. in English)

Dasgupta D, Pally D, Saini DK, Bhat R, Ghosh A.
PMID: 32918839
Angew Chem Int Ed Engl. 2020 Dec 21;59(52):23690-23696. doi: 10.1002/anie.202008681. Epub 2020 Oct 25.

The invasion of cancer is brought about by continuous interaction of malignant cells with their surrounding tissue microenvironment. Investigating the remodeling of local extracellular matrix (ECM) by invading cells can thus provide fundamental insights into the dynamics of cancer...

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Dasgupta D, Pally D, Saini DK, et al. Nanomotors Sense Local Physicochemical Heterogeneities in Tumor Microenvironments*. Angew Chem Int Ed Engl. 2020;59(52):23690-23696doi: 10.1002/anie.202008681.
Dasgupta, D., Pally, D., Saini, D. K., Bhat, R., & Ghosh, A. (2020). Nanomotors Sense Local Physicochemical Heterogeneities in Tumor Microenvironments*. Angewandte Chemie (International ed. in English), 59(52), 23690-23696. https://doi.org/10.1002/anie.202008681
Dasgupta, Debayan, et al. "Nanomotors Sense Local Physicochemical Heterogeneities in Tumor Microenvironments*." Angewandte Chemie (International ed. in English) vol. 59,52 (2020): 23690-23696. doi: https://doi.org/10.1002/anie.202008681
Dasgupta D, Pally D, Saini DK, Bhat R, Ghosh A. Nanomotors Sense Local Physicochemical Heterogeneities in Tumor Microenvironments*. Angew Chem Int Ed Engl. 2020 Dec 21;59(52):23690-23696. doi: 10.1002/anie.202008681. Epub 2020 Oct 25. PMID: 32918839; PMCID: PMC7756332.
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Lessons From 30 Years of Teaching About the Microenvironment of Tumors.

Cancer journal (Sudbury, Mass.)

Jain RK, Fukumura D, Duda DG.
PMID: 26049690
Cancer J. 2015 May-Jun;21(3):137. doi: 10.1097/PPO.0000000000000119.

No abstract available.

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Jain RK, Fukumura D, Duda DG. Lessons From 30 Years of Teaching About the Microenvironment of Tumors. Cancer J. 2015;21(3):137doi: 10.1097/PPO.0000000000000119.
Jain, R. K., Fukumura, D., & Duda, D. G. (2015). Lessons From 30 Years of Teaching About the Microenvironment of Tumors. Cancer journal (Sudbury, Mass.), 21(3), 137. https://doi.org/10.1097/PPO.0000000000000119
Jain, Rakesh K, et al. "Lessons From 30 Years of Teaching About the Microenvironment of Tumors." Cancer journal (Sudbury, Mass.) vol. 21,3 (2015): 137. doi: https://doi.org/10.1097/PPO.0000000000000119
Jain RK, Fukumura D, Duda DG. Lessons From 30 Years of Teaching About the Microenvironment of Tumors. Cancer J. 2015 May-Jun;21(3):137. doi: 10.1097/PPO.0000000000000119. PMID: 26049690; PMCID: PMC4792516.
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Immune landscape of inflammatory breast cancer suggests vulnerability to immune checkpoint inhibitors.

Oncoimmunology

Bertucci F, Boudin L, Finetti P, Van Berckelaer C, Van Dam P, Dirix L, Viens P, Gonçalves A, Ueno NT, Van Laere S, Birnbaum D, Mamessier E.
PMID: 34104544
Oncoimmunology. 2021 May 23;10(1):1929724. doi: 10.1080/2162402X.2021.1929724.

No abstract available.

Cite
Bertucci F, Boudin L, Finetti P, et al. Immune landscape of inflammatory breast cancer suggests vulnerability to immune checkpoint inhibitors. Oncoimmunology. 2021;10(1):1929724doi: 10.1080/2162402X.2021.1929724.
Bertucci, F., Boudin, L., Finetti, P., Van Berckelaer, C., Van Dam, P., Dirix, L., Viens, P., Gonçalves, A., Ueno, N. T., Van Laere, S., Birnbaum, D., & Mamessier, E. (2021). Immune landscape of inflammatory breast cancer suggests vulnerability to immune checkpoint inhibitors. Oncoimmunology, 10(1), 1929724. https://doi.org/10.1080/2162402X.2021.1929724
Bertucci, François, et al. "Immune landscape of inflammatory breast cancer suggests vulnerability to immune checkpoint inhibitors." Oncoimmunology vol. 10,1 (2021): 1929724. doi: https://doi.org/10.1080/2162402X.2021.1929724
Bertucci F, Boudin L, Finetti P, Van Berckelaer C, Van Dam P, Dirix L, Viens P, Gonçalves A, Ueno NT, Van Laere S, Birnbaum D, Mamessier E. Immune landscape of inflammatory breast cancer suggests vulnerability to immune checkpoint inhibitors. Oncoimmunology. 2021 May 23;10(1):1929724. doi: 10.1080/2162402X.2021.1929724. PMID: 34104544; PMCID: PMC8158040.
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Showing 1 to 12 of 12 entries