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Seitz O, Bergmann F, Heindl D. A Convergent Strategy for the Modification of Peptide Nucleic Acids: Novel Mismatch-Specific PNA-Hybridization Probes. Angew Chem Int Ed Engl. 1999;38(15):2203-2206doi: 10.1002/(sici)1521-3773(19990802)38:15<2203::aid-anie2203>3.0.co;2-2.
Seitz, O., Bergmann, F., & Heindl, D. (1999). A Convergent Strategy for the Modification of Peptide Nucleic Acids: Novel Mismatch-Specific PNA-Hybridization Probes. Angewandte Chemie (International ed. in English), 38(15), 2203-2206. https://doi.org/10.1002/(sici)1521-3773(19990802)38:15<2203::aid-anie2203>3.0.co;2-2
Seitz, et al. "A Convergent Strategy for the Modification of Peptide Nucleic Acids: Novel Mismatch-Specific PNA-Hybridization Probes." Angewandte Chemie (International ed. in English) vol. 38,15 (1999): 2203-2206. doi: https://doi.org/10.1002/(sici)1521-3773(19990802)38:15<2203::aid-anie2203>3.0.co;2-2
Seitz O, Bergmann F, Heindl D. A Convergent Strategy for the Modification of Peptide Nucleic Acids: Novel Mismatch-Specific PNA-Hybridization Probes. Angew Chem Int Ed Engl. 1999 Aug;38(15):2203-2206. doi: 10.1002/(sici)1521-3773(19990802)38:15<2203::aid-anie2203>3.0.co;2-2. PMID: 10425482.
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Angew Chem Int Ed Engl. 1999 Aug;38(15):2203-2206. doi: 10.1002/(sici)1521-3773(19990802)38:15<2203::aid-anie2203>3.0.co;2-2.

A Convergent Strategy for the Modification of Peptide Nucleic Acids: Novel Mismatch-Specific PNA-Hybridization Probes.

Angewandte Chemie (International ed. in English)

Seitz, Bergmann, Heindl

Affiliations

  1. Institut für Organische Chemie der Universität, Richard-Willstätter-Allee 2, D-76128 Karlsruhe (Germany).

PMID: 10425482 DOI: 10.1002/(sici)1521-3773(19990802)38:15<2203::aid-anie2203>3.0.co;2-2

Abstract

Coupling of nonnatural nucleobases to the orthogonally protected backbone 1 on the solid phase provided access to novel peptide nucleic acid (PNA) conjugates 2, which are difficult to synthesize by standard routes. Hybridization probes containing the thiazolorange dye might allow DNA sequence analysis in real time. B-CH(2)CO=modified nucleobase, fluorescent dye, etc; Boc, Fmoc=protecting groups.

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