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Trends Endocrinol Metab. 1999 Sep;10(7):262-267. doi: 10.1016/s1043-2760(99)00168-x.

The PTB Domain: The Name Doesn't Say It All.

Trends in endocrinology and metabolism: TEM

Margolis

Affiliations

  1. Howard Hughes Medical Institute, Departments of Internal Medicine and Biological Chemistry, University of Michigan Medical School, 4570 MSRB II, Box 0650, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0650, USA.

PMID: 10461172 DOI: 10.1016/s1043-2760(99)00168-x

Abstract

The phosphotyrosine-binding domain is a recently described protein-protein interaction domain which, despite its name, is involved in both phosphotyrosine-dependent and -independent interactions. Proteins with this domain are involved in diverse cellular functions, ranging from receptor signaling to protein targeting.

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