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Ursin R, Bjorvatn B, Sommerfelt L, et al. Studies on sleep/wake effects of serotonin reuptake inhibitors and receptor subtype involvement. J Sleep Res. 1992;1(3):157-162doi: 10.1111/j.1365-2869.1992.tb00031.x.
Ursin, R., Bjorvatn, B., Sommerfelt, L., Neckelmann, D., & Bjørkum, A. A. (1992). Studies on sleep/wake effects of serotonin reuptake inhibitors and receptor subtype involvement. Journal of sleep research, 1(3), 157-162. https://doi.org/10.1111/j.1365-2869.1992.tb00031.x
Ursin, et al. "Studies on sleep/wake effects of serotonin reuptake inhibitors and receptor subtype involvement." Journal of sleep research vol. 1,3 (1992): 157-162. doi: https://doi.org/10.1111/j.1365-2869.1992.tb00031.x
Ursin R, Bjorvatn B, Sommerfelt L, Neckelmann D, Bjørkum AA. Studies on sleep/wake effects of serotonin reuptake inhibitors and receptor subtype involvement. J Sleep Res. 1992 Sep;1(3):157-162. doi: 10.1111/j.1365-2869.1992.tb00031.x. PMID: 10607045.
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J Sleep Res. 1992 Sep;1(3):157-162. doi: 10.1111/j.1365-2869.1992.tb00031.x.

Studies on sleep/wake effects of serotonin reuptake inhibitors and receptor subtype involvement.

Journal of sleep research

Ursin, Bjorvatn, Sommerfelt, Neckelmann, Bjørkum

Affiliations

  1. Department of Physiology, University of Bergen, Bergen, Norway.

PMID: 10607045 DOI: 10.1111/j.1365-2869.1992.tb00031.x

Abstract

Studies with the serotonin uptake inhibitors zimeldine and alaproclate show biphasic effects on the sleep/wake axis in rats and cats. Zimeldine induced an initial waking response succeeded by a small SWS-2 increase in rats. The waking increase was not blocked by the 5-HT2 antagonist ritanserin nor by the putative 5-HT1A antagonist (-)-alprenolol. In cats, zimeldine induced initial behavioural changes which were succeeded by a large SWS-2 increase. Alaproclate gave similar initial responses as zimeldine in both species, and was succeeded by a moderate sleep increase in cats but not in rats. The complex sleep/wake effects following the serotonin uptake inhibitors may result from simultaneous induction of incompatible serotonergic effects.

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