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Grote L, Heitmann J, Penzel T, et al. Arterial hypertension and sleep apnoea: effect of the angiotensin-converting enzyme (ACE) inhibitor cilazapril on continuously measured blood pressure during sleep and wakefulness. J Sleep Res. 1995;4:112-116doi: 10.1111/j.1365-2869.1995.tb00199.x.
Grote, L., Heitmann, J., Penzel, T., Cassel, W., Ploch, T., Peter, J. H., & Von Wichert P. (1995). Arterial hypertension and sleep apnoea: effect of the angiotensin-converting enzyme (ACE) inhibitor cilazapril on continuously measured blood pressure during sleep and wakefulness. Journal of sleep research, 4112-116. https://doi.org/10.1111/j.1365-2869.1995.tb00199.x
Grote, et al. "Arterial hypertension and sleep apnoea: effect of the angiotensin-converting enzyme (ACE) inhibitor cilazapril on continuously measured blood pressure during sleep and wakefulness." Journal of sleep research vol. 4 (1995): 112-116. doi: https://doi.org/10.1111/j.1365-2869.1995.tb00199.x
Grote L, Heitmann J, Penzel T, Cassel W, Ploch T, Peter JH, Von Wichert P. Arterial hypertension and sleep apnoea: effect of the angiotensin-converting enzyme (ACE) inhibitor cilazapril on continuously measured blood pressure during sleep and wakefulness. J Sleep Res. 1995 Jun;4:112-116. doi: 10.1111/j.1365-2869.1995.tb00199.x. PMID: 10607186.
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J Sleep Res. 1995 Jun;4:112-116. doi: 10.1111/j.1365-2869.1995.tb00199.x.

Arterial hypertension and sleep apnoea: effect of the angiotensin-converting enzyme (ACE) inhibitor cilazapril on continuously measured blood pressure during sleep and wakefulness.

Journal of sleep research

Grote, Heitmann, Penzel, Cassel, Ploch, Peter, Von Wichert P

Affiliations

  1. Medizinische Poliklinik, Schlafmedizinisches Labor, Philipps-Universität Marburg, Germany.

PMID: 10607186 DOI: 10.1111/j.1365-2869.1995.tb00199.x

Abstract

Male patients with arterial hypertension and obstructive sleep-related breathing disorders (mean age 50 y, Body Mass Index (BMI) 32.4 kg m-2, Respiratory Disturbance Index (RDI) 47.2 and systolic/diastolic blood pressure (SBD/DBD) 162/103 mmHg) were examined before and after 8 days of treatment with the long-acting angiotensin-converting-enzyme (ACE) inhibitor cilazapril 2.5 mg vs. placebo in a double-blind design with parallel groups. Cardiorespiratory polysomnography was carried out at night; during daytime wakefulness patients submitted to examinations of physical and mental exertion. Cilazapril reduced the mean pressure during the entire examination period (day and night) by 9.55 (SD +/- 7.13) mmHg, compared to 4.57 (SD +/- 7.20) mmHg for placebo (P < 0.006), independently from systematic changes of heart rate (x = -3.3 and -3.5 bpm, respectively). During REM sleep, mean arterial pressure was significantly reduced by 8.63 (SD +/- 10.1) mmHg, compared to a reduction on placebo of 3.17 (SD 9.6) mmHg (P = 0.023). Under psychometric strain, the mean arterial pressure was reduced by 15.31 (SD +/- 8.7) mmHg with cilazapril; under placebo medication by 6.19 (SD +/- 7.3) mmHg (P < 0.0001). Heart rate was not significantly changed.

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