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White HD, Yusuf S. Issues Regarding the Use of Heparin Following Streptokinase Therapy. J Thromb Thrombolysis. 1995;2(1):5-10doi: 10.1007/BF01063155.
White, H. D., & Yusuf, S. (1995). Issues Regarding the Use of Heparin Following Streptokinase Therapy. Journal of thrombosis and thrombolysis, 2(1), 5-10. https://doi.org/10.1007/BF01063155
White, and Yusuf. "Issues Regarding the Use of Heparin Following Streptokinase Therapy." Journal of thrombosis and thrombolysis vol. 2,1 (1995): 5-10. doi: https://doi.org/10.1007/BF01063155
White HD, Yusuf S. Issues Regarding the Use of Heparin Following Streptokinase Therapy. J Thromb Thrombolysis. 1995;2(1):5-10. doi: 10.1007/BF01063155. PMID: 10639209.
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J Thromb Thrombolysis. 1995;2(1):5-10. doi: 10.1007/BF01063155.

Issues Regarding the Use of Heparin Following Streptokinase Therapy.

Journal of thrombosis and thrombolysis

White, Yusuf

Affiliations

  1. Coronary Care and Cardiovascular Research, Green Lane Hospital, Auckland, New Zealand.

PMID: 10639209 DOI: 10.1007/BF01063155

Abstract

The success of thrombolytic therapy is dependent upon the balance of fibrinolytic activity and procoagulant activity. Streptokinase produces fibrin degradation products that have anticoagulant effects and may potentially protect against reocclusion. However, streptokinase also activates platelets and thrombin, and the prothrombotic effects may be more marked than after administration of recombinant tissue plasminogen activator (rt-PA). Administration of high-dose, delayed subcutaneous heparin after streptokinase and aspirin has been shown to have some benefits and some risks. The benefits and risks of adding intravenous heparin to aspirin and streptokinase have not been clearly defined.

References

  1. N Engl J Med. 1986 Oct 9;315(15):913-9 - PubMed
  2. J Am Coll Cardiol. 1987 Sep;10(3):527-9 - PubMed
  3. Lancet. 1990 Jul 14;336(8707):65-71 - PubMed
  4. Lancet. 1991 Apr 20;337(8747):945-6 - PubMed
  5. J Am Coll Cardiol. 1994 Nov 15;24(6):1445-52 - PubMed
  6. Circulation. 1976 Apr;53(4):691-5 - PubMed
  7. J Biol Chem. 1982 Mar 10;257(5):2162-9 - PubMed
  8. Thromb Haemost. 1988 Dec 22;60(3):457-62 - PubMed
  9. Am J Cardiol. 1987 Feb 1;59(4):241-4 - PubMed
  10. Thromb Haemost. 1988 Jun 16;59(3):541-2 - PubMed
  11. N Engl J Med. 1989 Feb 9;320(6):352-7 - PubMed
  12. Thromb Res. 1989 Sep 1;55(5):635-43 - PubMed
  13. Blood. 1989 Jan;73(1):185-90 - PubMed
  14. Lancet. 1990 Jul 14;336(8707):71-5 - PubMed
  15. Blood. 1989 Sep;74(4):1181-95 - PubMed
  16. J Clin Invest. 1991 Mar;87(3):1082-90 - PubMed
  17. Lancet. 1990 Oct 6;336(8719):827-30 - PubMed
  18. Am J Cardiol. 1991 Jan 25;67(3):3A-11A - PubMed
  19. Br Heart J. 1985 Apr;53(4):363-73 - PubMed
  20. Circulation. 1990 Oct;82(4):1476-84 - PubMed
  21. Chest. 1992 Apr;101(4 Suppl):131S-139S - PubMed
  22. Lancet. 1986 Feb 22;1(8478):397-402 - PubMed
  23. Lancet. 1986 May 31;1(8492):1278-9 - PubMed
  24. J Clin Invest. 1991 May;87(5):1787-93 - PubMed
  25. N Engl J Med. 1990 Nov 22;323(21):1433-7 - PubMed
  26. J Clin Invest. 1990 Aug;86(2):385-91 - PubMed
  27. Thromb Res. 1984 Sep 1;35(5):527-37 - PubMed
  28. J Am Coll Cardiol. 1992 Sep;20(3):513-9 - PubMed
  29. Br Heart J. 1992 Feb;67(2):122-8 - PubMed
  30. Circulation. 1991 Mar;83(3):937-44 - PubMed
  31. Circulation. 1989 Dec;80(6):1718-25 - PubMed
  32. J Am Coll Cardiol. 1992 Jul;20(1):31-5 - PubMed
  33. Lancet. 1989 Jul 22;2(8656):182-6 - PubMed
  34. J Clin Pathol. 1968 Mar;21(2):147-53 - PubMed
  35. Circulation. 1989 May;79(5):980-9 - PubMed
  36. Nature. 1977 Feb 17;265(5595):625-6 - PubMed
  37. Circulation. 1988 Jan;77(1):142-50 - PubMed
  38. Am J Cardiol. 1990 Dec 15;66(20):1412-7 - PubMed
  39. Lancet. 1992 Mar 28;339(8796):753-70 - PubMed
  40. Eur Heart J. 1985 Jul;6(7):556-85 - PubMed
  41. Blood. 1988 Aug;72(2):616-20 - PubMed
  42. Circ Res. 1994 Oct;75(4):701-10 - PubMed
  43. J Biol Chem. 1986 Mar 25;261(9):3980-6 - PubMed
  44. Circulation. 1986 Sep;74(3):583-7 - PubMed
  45. N Engl J Med. 1988 Oct 27;319(17):1105-11 - PubMed
  46. N Engl J Med. 1993 Sep 2;329(10 ):673-82 - PubMed
  47. Br Heart J. 1990 Aug;64(2):118-20 - PubMed
  48. Am J Cardiol. 1990 Jul 1;66(1):28-30 - PubMed
  49. Am Heart J. 1989 Feb;117(2):275-81 - PubMed
  50. J Am Coll Cardiol. 1983 May;1(5):1247-53 - PubMed

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