Display options
Cite
Anson CE, Bibb MJ, Booker-Milburn KI, et al. Genetic Engineering of Streptomyces coelicolor A3(2) for the Enantioselective Reduction of Unnatural beta-Keto-Ester Substrates. Angew Chem Int Ed Engl. 2000;39(1):224-227
Anson, C. E., Bibb, M. J., Booker-Milburn, K. I., Clissold, C., Haley, P. J., Hopwood, D. A., Ichinose, K., Revill, W. P., Stephenson, G. R., & Surti, C. M. (2000). Genetic Engineering of Streptomyces coelicolor A3(2) for the Enantioselective Reduction of Unnatural beta-Keto-Ester Substrates. Angewandte Chemie (International ed. in English), 39(1), 224-227.
Anson, et al. "Genetic Engineering of Streptomyces coelicolor A3(2) for the Enantioselective Reduction of Unnatural beta-Keto-Ester Substrates." Angewandte Chemie (International ed. in English) vol. 39,1 (2000): 224-227.
Anson CE, Bibb MJ, Booker-Milburn KI, Clissold C, Haley PJ, Hopwood DA, Ichinose K, Revill WP, Stephenson GR, Surti CM. Genetic Engineering of Streptomyces coelicolor A3(2) for the Enantioselective Reduction of Unnatural beta-Keto-Ester Substrates. Angew Chem Int Ed Engl. 2000 Jan;39(1):224-227. PMID: 10649383.
Copy Download .nbib Format: NLM
Share it on

Angew Chem Int Ed Engl. 2000 Jan;39(1):224-227.

Genetic Engineering of Streptomyces coelicolor A3(2) for the Enantioselective Reduction of Unnatural beta-Keto-Ester Substrates.

Angewandte Chemie (International ed. in English)

Anson, Bibb, Booker-Milburn, Clissold, Haley, Hopwood, Ichinose, Revill, Stephenson, Surti

Affiliations

  1. School of Chemical Sciences University of East Anglia Norwich NR4 7TJ (UK).

PMID: 10649383

Abstract

Potential "reagents" for the enantioselective reduction, and other biotransformations, of beta-keto-esters result from the genetic engineering of Streptomyces coelicolor A3(2). For example, incubation of the N-acetylcysteamine thioester 1 with the recombinant strain CH999/pIJ5675 followed by treatment with MeOH/HCl gave the lactone 2 as essentially a single enantiomer.

Publication Types