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Paterson I, Florence GJ, Gerlach K, et al. Total Synthesis of the Antimicrotubule Agent (+)-Discodermolide Using Boron-Mediated Aldol Reactions of Chiral Ketones. Angew Chem Int Ed Engl. 2000;39(2):377-380doi: 10.1002/(sici)1521-3773(20000117)39:2<377::aid-anie377>3.0.co;2-e.
Paterson, I., Florence, G. J., Gerlach, K., & Scott, J. P. (2000). Total Synthesis of the Antimicrotubule Agent (+)-Discodermolide Using Boron-Mediated Aldol Reactions of Chiral Ketones. Angewandte Chemie (International ed. in English), 39(2), 377-380. https://doi.org/10.1002/(sici)1521-3773(20000117)39:2<377::aid-anie377>3.0.co;2-e
Paterson, et al. "Total Synthesis of the Antimicrotubule Agent (+)-Discodermolide Using Boron-Mediated Aldol Reactions of Chiral Ketones." Angewandte Chemie (International ed. in English) vol. 39,2 (2000): 377-380. doi: https://doi.org/10.1002/(sici)1521-3773(20000117)39:2<377::aid-anie377>3.0.co;2-e
Paterson I, Florence GJ, Gerlach K, Scott JP. Total Synthesis of the Antimicrotubule Agent (+)-Discodermolide Using Boron-Mediated Aldol Reactions of Chiral Ketones. Angew Chem Int Ed Engl. 2000 Jan;39(2):377-380. doi: 10.1002/(sici)1521-3773(20000117)39:2<377::aid-anie377>3.0.co;2-e. PMID: 10649416.
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Angew Chem Int Ed Engl. 2000 Jan;39(2):377-380. doi: 10.1002/(sici)1521-3773(20000117)39:2<377::aid-anie377>3.0.co;2-e.

Total Synthesis of the Antimicrotubule Agent (+)-Discodermolide Using Boron-Mediated Aldol Reactions of Chiral Ketones.

Angewandte Chemie (International ed. in English)

Paterson, Florence, Gerlach, Scott

Affiliations

  1. University Chemical Laboratory Lensfield Road, Cambridge CB2 1EW (UK).

PMID: 10649416 DOI: 10.1002/(sici)1521-3773(20000117)39:2<377::aid-anie377>3.0.co;2-e

Abstract

With a similar mechanism of action to taxol, the title compound 1 is a particularly promising candidate for development in cancer chemotherapy. This efficient synthesis, based on stereocontrolled aldol reactions, should help to overcome the scarce natural supply of 1 from the rare sponge source.

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