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Obes Surg. 1993 May;3(2):175-177. doi: 10.1381/096089293765559548.

Wernicke-Korsakoff Encephalopathy Following Biliopancreatic Diversion.

Obesity surgery

Primavera, Brusa, Novello, Schenone, Gianetta, Marinari, Cuneo, Scopinaro

Affiliations

  1. Department of Neurology, University of Genoa, Genoa, 16132 Italy.

PMID: 10757916 DOI: 10.1381/096089293765559548

Abstract

Wernicke-Korsakoff disease with sensory-motor neuropathy was diagnosed in three out of a series of 1,663 patients (0.18%), with onset 2, 3 and 5 months after biliopancreatic diversion. Precipitating factors were vomiting, minimal food intake, anorexia, rapid weight loss, and glucose-containing intravenous feeding. Recovery was partial in two and complete in one of the patients. In the early postop, prophylactic thiamine should be given to the patients with excessively limited eating capacity. Larger doses of thiamine should be instituted parenterally either in the case of suspected Wernicke-Korsakoff encephalopathy or before starting feeding for protein malnutrition.

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