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Herzog WR, Gurbel PA, Vogel RA, et al. Effects of a Novel Leumedin NPC 15669 on Myocardial Stunning and Preconditioned Infarction Size in Swine. J Thromb Thrombolysis. 1995;1(2):163-170doi: 10.1007/BF01062574.
Herzog, W. R., Gurbel, P. A., Vogel, R. A., Schlossberg, M. L., Schneider, A. I., & Serebruany, V. L. (1995). Effects of a Novel Leumedin NPC 15669 on Myocardial Stunning and Preconditioned Infarction Size in Swine. Journal of thrombosis and thrombolysis, 1(2), 163-170. https://doi.org/10.1007/BF01062574
Herzog, et al. "Effects of a Novel Leumedin NPC 15669 on Myocardial Stunning and Preconditioned Infarction Size in Swine." Journal of thrombosis and thrombolysis vol. 1,2 (1995): 163-170. doi: https://doi.org/10.1007/BF01062574
Herzog WR, Gurbel PA, Vogel RA, Schlossberg ML, Schneider AI, Serebruany VL. Effects of a Novel Leumedin NPC 15669 on Myocardial Stunning and Preconditioned Infarction Size in Swine. J Thromb Thrombolysis. 1995;1(2):163-170. doi: 10.1007/BF01062574. PMID: 10603526.
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J Thromb Thrombolysis. 1995;1(2):163-170. doi: 10.1007/BF01062574.

Effects of a Novel Leumedin NPC 15669 on Myocardial Stunning and Preconditioned Infarction Size in Swine.

Journal of thrombosis and thrombolysis

Herzog, Gurbel, Vogel, Schlossberg, Schneider, Serebruany

Affiliations

  1. Department of Medicine, Division of Cardiology, University of Maryland Medical Center, Baltimore, MD.

PMID: 10603526 DOI: 10.1007/BF01062574

Abstract

Background: NPC is a member of the leumedins and is an inhibitor of leukocyte adhesion to endothelium via blockage of integrin binding. NPC 15669 also may have antiplatelet effects. We tested the efficacy of the novel leukocyte recruitment inhibitor NPC 15669 on myocardial stunning (MS) and preconditioned myocardial infarction (MI). Methods and Results: In an open-chested swine model, NPC 15669 (10 rng NPC/kg loading dose followed by constant infusion at 6 mg/kg/hr) was administered in six animals. Myocardial thickening (MT) was determined by epicardial ultrasound. The left anterior descending artery was occluded for 8 minutes followed by 90 minutes of reperfusion, during which myocardial MT was recorded at regular intervals. We have found that treatment with NPC 15669 increases myocardial contractility and significantly decreases MS time compared to controls (26.7 +/- 4.0 minutes vs. 50.0 +/- 4.3 minutes, p =.0026). In NPC 15669-treated animals we observed a reduction of MI size (23.4 +/- 6.7% of tissue at risk became necrotic compared to 53.0 +/- 6.6% in controls, p =.0102). Conclusions: Our data suggest that NPC 15669 significantly reduces myocardial injury in both the stunning and infarction models.

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