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Bender NK, Kraynak MA, Chiquette E, et al. Effects of Marine Fish Oils on the Anticoagulation Status of Patients Receiving Chronic Warfarin Therapy. J Thromb Thrombolysis. 1998;5(3):257-261doi: 10.1023/A:1008852127668.
Bender, N. K., Kraynak, M. A., Chiquette, E., Linn, W. D., Clark, G. M., & Bussey, H. I. (1998). Effects of Marine Fish Oils on the Anticoagulation Status of Patients Receiving Chronic Warfarin Therapy. Journal of thrombosis and thrombolysis, 5(3), 257-261. https://doi.org/10.1023/A:1008852127668
Bender, et al. "Effects of Marine Fish Oils on the Anticoagulation Status of Patients Receiving Chronic Warfarin Therapy." Journal of thrombosis and thrombolysis vol. 5,3 (1998): 257-261. doi: https://doi.org/10.1023/A:1008852127668
Bender NK, Kraynak MA, Chiquette E, Linn WD, Clark GM, Bussey HI. Effects of Marine Fish Oils on the Anticoagulation Status of Patients Receiving Chronic Warfarin Therapy. J Thromb Thrombolysis. 1998 Jul;5(3):257-261. doi: 10.1023/A:1008852127668. PMID: 10767122.
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J Thromb Thrombolysis. 1998 Jul;5(3):257-261. doi: 10.1023/A:1008852127668.

Effects of Marine Fish Oils on the Anticoagulation Status of Patients Receiving Chronic Warfarin Therapy.

Journal of thrombosis and thrombolysis

Bender, Kraynak, Chiquette, Linn, Clark, Bussey

Affiliations

  1. The University of Texas Health Sciences Center, Division of Pharmacotherapy, San Antonio, Texas, USA.

PMID: 10767122 DOI: 10.1023/A:1008852127668

Abstract

The purpose of this placebo-controlled, randomized, double-blinded, parallel study was to determine the existence and magnitude of effect of various doses of fish oil supplements on International Normalized Ratio (INR) determinations in patients receiving chronic warfarin therapy. Patients from anticoagulation clinics from both the Brady Green Community Health Center and Audie L. Murphy Veterans Administration in San Antonio, Texas were enrolled in the study. The enrolled subjects included 5 males and 11 females, all of whom were receiving chronic warfarin therapy for indications requiring oral anticoagulation. All enrolled patients underwent a 4-week placebo monitoring period in which INRs were determined on a weekly basis. If the INRs were found to be stable, patients were randomized to receive a 4-week treatment period of either placebo capsules (n = 6), 3 grams of fish oil daily (n = 5), or 6 grams of fish oil daily (n = 5). Patients were followed on a twice-weekly basis for INR determinations and adverse reactions. Five patients were discontinued from the study due to noncompliance (2) and unstable INRs (3). There was no statistically significant difference in INRs between the placebo lead-in and treatment period within each group (P = 0.82). There was also no difference in INRs found between groups (P= 0.41). One bruising episode was reported, yet no major bleeding episodes were observed during the study. Fish oil supplementation in doses of 3-6 grams per day does not seem to create a statistically significant effect on the anticoagulation status of patients receiving chronic warfarin therapy.

References

  1. N Engl J Med. 1989 Apr 20;320(16):1037-43 - PubMed
  2. Am J Med. 1988 Jan;84(1):45-52 - PubMed
  3. Circulation. 1994 Nov;90(5):2248-57 - PubMed
  4. Acta Med Scand. 1976;200(1-2):69-73 - PubMed
  5. Atherosclerosis. 1988 Mar;70(1-2):73-80 - PubMed
  6. Am J Hematol. 1987 Feb;24(2):143-9 - PubMed
  7. Thromb Res. 1986 Sep 15;43(6):643-55 - PubMed
  8. Circulation. 1992 Mar;85(3):950-6 - PubMed
  9. Arch Intern Med. 1993 Jul 12;153(13):1595-601 - PubMed
  10. Atherosclerosis. 1984 Jan;50(1):3-10 - PubMed
  11. Chest. 1992 Oct;102(4 Suppl):374S-384S - PubMed
  12. Am J Prev Med. 1992 May-Jun;8(3):186-92 - PubMed
  13. N Engl J Med. 1988 Sep 22;319(12):733-40 - PubMed
  14. Thromb Res. 1989 Mar 1;53(5):467-74 - PubMed
  15. N Engl J Med. 1986 Apr 10;314(15):937-42 - PubMed
  16. Chest. 1995 Oct;108(4 Suppl):302S-304S - PubMed
  17. Arch Intern Med. 1992 Feb;152(2):278-82 - PubMed

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