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Heinonen TM, Schrott H, McKenney JM, et al. Atorvastatin, a New HMG-CoA Reductase Inhibitor as Monotherapy and Combined With Colestipol. J Cardiovasc Pharmacol Ther. 1996;1(2):117-122doi: 10.1177/107424849600100205.
Heinonen, T. M., Schrott, H., McKenney, J. M., Sniderman, A. D., Broyles, F. E., Zavoral, J. H., Kivel, F., & Black, D. M. (1996). Atorvastatin, a New HMG-CoA Reductase Inhibitor as Monotherapy and Combined With Colestipol. Journal of cardiovascular pharmacology and therapeutics, 1(2), 117-122. https://doi.org/10.1177/107424849600100205
Heinonen, et al. "Atorvastatin, a New HMG-CoA Reductase Inhibitor as Monotherapy and Combined With Colestipol." Journal of cardiovascular pharmacology and therapeutics vol. 1,2 (1996): 117-122. doi: https://doi.org/10.1177/107424849600100205
Heinonen TM, Schrott H, McKenney JM, Sniderman AD, Broyles FE, Zavoral JH, Kivel F, Black DM. Atorvastatin, a New HMG-CoA Reductase Inhibitor as Monotherapy and Combined With Colestipol. J Cardiovasc Pharmacol Ther. 1996 Apr;1(2):117-122. doi: 10.1177/107424849600100205. PMID: 10684408.
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J Cardiovasc Pharmacol Ther. 1996 Apr;1(2):117-122. doi: 10.1177/107424849600100205.

Atorvastatin, a New HMG-CoA Reductase Inhibitor as Monotherapy and Combined With Colestipol.

Journal of cardiovascular pharmacology and therapeutics

Heinonen, Schrott, McKenney, Sniderman, Broyles, Zavoral, Kivel, Black

Affiliations

  1. Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan, USA

PMID: 10684408 DOI: 10.1177/107424849600100205

Abstract

BACKGROUND: Atorvastatin, a new HMG-CoA reductase inhibitor in clinical development has demonstrated an acceptable safety profile and marked cholesterol and triglyceride reduction at doses ranging from 10-80 mg/day. Since bile acid sequestering resins are often used in combination with HMGRIs to enhance cholesterol reduction, this trial was conducted to explore the use of atorvastatin alone and combined with colestipol in patients with primary hyperlipidemia. METHODS AND RESULTS: One hundred six patients with low-density lipoprotein (LDL) cholesterol >4.1 mM/L (160 mg/dL) and plasma triglycerides <3.9 mM/L (350 mg/dL) were randomized to treatment consisting of 20 g/day colestipol, 10 mg/day atorvastatin, or 10 mg/day atorvastatin plus 20 g/day colestipol for 12 weeks. Percent change from baseline in lipid variables were measured. The atorvastatin group showed a significant reduction in LDL cholesterol of 35% after 12 weeks. Combination therapy provided an additional 10% reduction in LDL cholesterol over that observed for atorvastatin alone. Twenty-one percent of all patients in the atorvastatin monotherapy group experienced associated adverse events compared with 60% in the combination therapy group. Ninety percent of atorvastatin monotherapy patients were compliant at every visit compared with 75% receiving combination therapy. CONCLUSIONS: Although the combination of atorvastatin plus colestipol was more effective in lowering LDL cholesterol than atorvastatin alone, atorvastatin 10 mg/day monotherapy provided a better safety profile and improved patient compliance, which may result in improved long-term cholesterol control.

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