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Sharma SK, Chapman D, Temsah R, et al. Prevention of Vascular Apoptosis in Myocardial Infarction by Losartan. J Cardiovasc Pharmacol Ther. 1999;4(2):77-84doi: 10.1177/107424849900400202.
Sharma, S. K., Chapman, D., Temsah, R., Netticadan, T., Brasil, D. P., & Dhalla, N. S. (1999). Prevention of Vascular Apoptosis in Myocardial Infarction by Losartan. Journal of cardiovascular pharmacology and therapeutics, 4(2), 77-84. https://doi.org/10.1177/107424849900400202
Sharma, et al. "Prevention of Vascular Apoptosis in Myocardial Infarction by Losartan." Journal of cardiovascular pharmacology and therapeutics vol. 4,2 (1999): 77-84. doi: https://doi.org/10.1177/107424849900400202
Sharma SK, Chapman D, Temsah R, Netticadan T, Brasil DP, Dhalla NS. Prevention of Vascular Apoptosis in Myocardial Infarction by Losartan. J Cardiovasc Pharmacol Ther. 1999 Apr;4(2):77-84. doi: 10.1177/107424849900400202. PMID: 10684526.
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J Cardiovasc Pharmacol Ther. 1999 Apr;4(2):77-84. doi: 10.1177/107424849900400202.

Prevention of Vascular Apoptosis in Myocardial Infarction by Losartan.

Journal of cardiovascular pharmacology and therapeutics

Sharma, Chapman, Temsah, Netticadan, Brasil, Dhalla

Affiliations

  1. Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre, Winnipeg, Canada

PMID: 10684526 DOI: 10.1177/107424849900400202

Abstract

BACKGROUND: Previous studies have demonstrated the occurrence of apoptosis in cardiomyocytes in different types of cardiovascular diseases. This report provides the first evidence for the presence of vascular apoptosis in myocardial infarction induced in rats by occluding the coronary artery for 7 weeks. METHODS AND RESULTS: Apoptosis was characterized by DNA fragmentation, upregulation of caspase-3, downregulation of poly (ADP-ribose) polymerase (PARP), increased c-fos mRNA expression and caspase-3/PARP ratio in aortic vascular smooth muscle cells. The results show apoptotic changes in 10-25% of the aortic vascular cells after myocardial infarction; these alterations were prevented after treating the 3-week operated animals with an angiotensin II receptor antagonist, losartan (25 mg/kg/day; intraperitoneal) for 4 weeks. Cultured rat aortic smooth muscle cells exposed to 10 nmol/L angiotensin II for 48 hours also exhibited apoptotic changes, which were inhibited by 10 nmol/L losartan. CONCLUSIONS: These results suggest that vascular apoptosis occurs in myocardial infarction, and this may be due to an increase in the circulating levels of angiotensin II.

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