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Dubin A. Antiarrhythmic drug therapy in the neonate. Prog Pediatr Cardiol. 2000;11(1):55-63doi: 10.1016/s1058-9813(00)00036-9.
Dubin, A. (2000). Antiarrhythmic drug therapy in the neonate. Progress in pediatric cardiology, 11(1), 55-63. https://doi.org/10.1016/s1058-9813(00)00036-9
Dubin. "Antiarrhythmic drug therapy in the neonate." Progress in pediatric cardiology vol. 11,1 (2000): 55-63. doi: https://doi.org/10.1016/s1058-9813(00)00036-9
Dubin A. Antiarrhythmic drug therapy in the neonate. Prog Pediatr Cardiol. 2000 May 01;11(1):55-63. doi: 10.1016/s1058-9813(00)00036-9. PMID: 10822190.
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Prog Pediatr Cardiol. 2000 May 01;11(1):55-63. doi: 10.1016/s1058-9813(00)00036-9.

Antiarrhythmic drug therapy in the neonate.

Progress in pediatric cardiology

Dubin

Affiliations

  1. Division of Pediatric Cardiology, Stanford University, 750 Welch Rd., Suite 305, Palo Alto, CA, USA

PMID: 10822190 DOI: 10.1016/s1058-9813(00)00036-9

Abstract

The neonate presents a challenge for the practitioner considering antiarrhythmic therapy: pharmacokinetics are different than in older children or adults; and the arrhythmia substrate may also differ, with respect to issues of ion channel and autonomic nervous system development. This paper reviews the need for antiarrhythmic drug therapy in the neonate, developmental aspects of pharmacokinetics, autonomic regulation and cellular electrophysiology and the antiarrhythmics available today with an emphasis on newer drug therapy.

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