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Biteau N, Bringaud F, Gibson W, et al. Characterization of Trypanozoon isolates using a repeated coding sequence and microsatellite markers. Mol Biochem Parasitol. 2000;105(2):187-202
Biteau, N., Bringaud, F., Gibson, W., Truc, P., & Baltz, T. (2000). Characterization of Trypanozoon isolates using a repeated coding sequence and microsatellite markers. Molecular and biochemical parasitology, 105(2), 187-202.
Biteau, et al. "Characterization of Trypanozoon isolates using a repeated coding sequence and microsatellite markers." Molecular and biochemical parasitology vol. 105,2 (2000): 187-202.
Biteau N, Bringaud F, Gibson W, Truc P, Baltz T. Characterization of Trypanozoon isolates using a repeated coding sequence and microsatellite markers. Mol Biochem Parasitol. 2000 Feb 05;105(2):187-202. PMID: 10745102.
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Mol Biochem Parasitol. 2000 Feb 05;105(2):187-202.

Characterization of Trypanozoon isolates using a repeated coding sequence and microsatellite markers.

Molecular and biochemical parasitology

Biteau, Bringaud, Gibson, Truc, Baltz

Affiliations

  1. Laboratoire de Parasitologie Moléculaire, Université Victor Segalen de Bordeaux II, UPRESA-5016 CNRS, 146 Rue Léo Saignat, 33076, Bordeaux, France

PMID: 10745102

Abstract

Genetic variation of microsatellite loci is a widely used method for linkage analysis, individual identification or inter-population studies. Here we analyse a repeated DNA coding sequence and eleven new microsatellites identified within the Trypanosoma (Trypanozoon) brucei genome. Ninety-seven isolates belonging to the five species and subspecies Trypanosoma evansi, T. equiperdum, T. brucei brucei, T. b. rhodesiense and T. b. gambiense were compared regarding the genetic patterns of these markers. The results reveal a great heterogeneity of the genotypes related to the repeated coding sequence and five microsatellites, some of which show a high degree of polymorphism. This allows us to define group-specific genotypes or alleles; in particular, we show that one specific pattern clearly segregates the human pathogen T. b. gambiense group 1.

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