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Hall ML, Wolfson AJ. Journal club as a supplement to the undergraduate biochemistry laboratory. Biochem Educ. 2000;28(2):71-73
Hall, M. L., & Wolfson, A. J. (2000). Journal club as a supplement to the undergraduate biochemistry laboratory. Biochemical education, 28(2), 71-73.
Hall, and Wolfson. "Journal club as a supplement to the undergraduate biochemistry laboratory." Biochemical education vol. 28,2 (2000): 71-73.
Hall ML, Wolfson AJ. Journal club as a supplement to the undergraduate biochemistry laboratory. Biochem Educ. 2000 Mar 01;28(2):71-73. PMID: 10722934.
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Biochem Educ. 2000 Mar 01;28(2):71-73.

Journal club as a supplement to the undergraduate biochemistry laboratory.

Biochemical education

Hall, Wolfson

Affiliations

  1. Department of Chemistry, Wellesley College, Wellesley, USA

PMID: 10722934

Abstract

After purification of lysozyme, our biochemistry students write a research proposal that outlines a strategy for studying this enzyme after alteration by site-directed mutagenesis. Despite a literature search that yielded a wealth of background information, students were often overwhelmed by the assignment because they were not familiar with advanced techniques of protein analysis. We therefore developed a series of journal clubs in which teams of students present methods and data found in papers dealing with lysozyme. The five topics for journal clubs include; substrate binding and mechanism; spectroscopic techniques; stability analysis; two-dimensional NMR; and X-ray crystallography. After the adoption of the group talks, the quality of the research proposals improved immensely and students found the assignment to be an educationally rewarding exercise.

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