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Borth S, Hansel W, Rosner P, et al. Regioisomeric differentiation of 2,3- and 3,4-methylenedioxy ring-substituted phenylalkylamines by gas chromatography/tandem mass spectrometry. J Mass Spectrom. 2000;35(6):705-10doi: 10.1002/1096-9888(200006)35:6<705::AID-JMS997>3.0.CO;2-3.
Borth, S., Hansel, W., Rosner, P., & Junge, T. (2000). Regioisomeric differentiation of 2,3- and 3,4-methylenedioxy ring-substituted phenylalkylamines by gas chromatography/tandem mass spectrometry. Journal of mass spectrometry : JMS, 35(6), 705-10. https://doi.org/10.1002/1096-9888(200006)35:6<705::AID-JMS997>3.0.CO;2-3
Borth, et al. "Regioisomeric differentiation of 2,3- and 3,4-methylenedioxy ring-substituted phenylalkylamines by gas chromatography/tandem mass spectrometry." Journal of mass spectrometry : JMS vol. 35,6 (2000): 705-10. doi: https://doi.org/10.1002/1096-9888(200006)35:6<705::AID-JMS997>3.0.CO;2-3
Borth S, Hansel W, Rosner P, Junge T. Regioisomeric differentiation of 2,3- and 3,4-methylenedioxy ring-substituted phenylalkylamines by gas chromatography/tandem mass spectrometry. J Mass Spectrom. 2000 Jun;35(6):705-10. doi: 10.1002/1096-9888(200006)35:6<705::AID-JMS997>3.0.CO;2-3. PMID: 10862122.
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J Mass Spectrom. 2000 Jun;35(6):705-10. doi: 10.1002/1096-9888(200006)35:6<705::AID-JMS997>3.0.CO;2-3.

Regioisomeric differentiation of 2,3- and 3,4-methylenedioxy ring-substituted phenylalkylamines by gas chromatography/tandem mass spectrometry.

Journal of mass spectrometry : JMS

Borth, Hansel, Rosner, Junge

Affiliations

  1. Pharmazeutisches Institut, Christian Albrechts Universitat Kiel, Gutenbergstrasse 76, D-24118 Kiel, Germany.

PMID: 10862122 DOI: 10.1002/1096-9888(200006)35:6<705::AID-JMS997>3.0.CO;2-3

Abstract

Numerous abused drugs of the 3,4-methylenedioxymetamphetamine (MDMA; Ecstasy; N-methyl-1-(3,4-methylenedioxyphenyl)-2-propaneamine) type and various alkyl chain- and aromatic ring-substituted isomers give very similar electron ionization (EI) mass spectra. This seriously affects the analysis of especially ring regioisomeric drug variants. Using collision-induced dissociation (CID) (argon) under EI and chemical ionization, the mass spectra of 18 2,3- and 3, 4-methylenedioxy ring-substituted phenylethylamines were recorded. These techniques permitted an unequivocal differentiation of all studied ring regioisomeric methylenedioxyphenylethylamines. CID mass spectrometry therefore appear to be a reliable tool to establish the kind of ring substitution pattern in regioisomeric methylenedioxyphenalkylamines. Copyright 2000 John Wiley & Sons, Ltd.

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