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Kidane A, McPherson T, Shim HS, et al. Surface modification of polyethylene terephthalate using PEO-polybutadiene-PEO triblock copolymers. Colloids Surf B Biointerfaces. 2000;18(3):347-353doi: 10.1016/s0927-7765(99)00160-5.
Kidane, A., McPherson, T., Shim, H. S., & Park, K. (2000). Surface modification of polyethylene terephthalate using PEO-polybutadiene-PEO triblock copolymers. Colloids and surfaces. B, Biointerfaces, 18(3), 347-353. https://doi.org/10.1016/s0927-7765(99)00160-5
Kidane, et al. "Surface modification of polyethylene terephthalate using PEO-polybutadiene-PEO triblock copolymers." Colloids and surfaces. B, Biointerfaces vol. 18,3 (2000): 347-353. doi: https://doi.org/10.1016/s0927-7765(99)00160-5
Kidane A, McPherson T, Shim HS, Park K. Surface modification of polyethylene terephthalate using PEO-polybutadiene-PEO triblock copolymers. Colloids Surf B Biointerfaces. 2000 Oct 01;18(3):347-353. doi: 10.1016/s0927-7765(99)00160-5. PMID: 10915956.
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Colloids Surf B Biointerfaces. 2000 Oct 01;18(3):347-353. doi: 10.1016/s0927-7765(99)00160-5.

Surface modification of polyethylene terephthalate using PEO-polybutadiene-PEO triblock copolymers.

Colloids and surfaces. B, Biointerfaces

Kidane, McPherson, Shim, Park

Affiliations

  1. Purdue University, School of Pharmacy, Departments of Pharmaceutics and Biomedical Engineering, 47907-1336, West Lafayette, IN, USA

PMID: 10915956 DOI: 10.1016/s0927-7765(99)00160-5

Abstract

The initial step of thrombus formation on blood-contacting biomaterials is known to be adsorption of blood proteins followed by platelet adhesion. It is generally accepted that surface modification of the biomaterials with poly(ethylene oxide) (PEO) substantially reduces protein adsorption and cell adhesion. Dacron(R) (polyethylene terephthalate) fabric, which is one of the biomaterials commonly used in blood-contacting devices, was grafted with PEO. A simple two-step procedure for covalent grafting of PEO onto the surface of Dacron(R) fabric was used. The surface was first treated with PEO-polybutadiene-PEO (PEO-PB-PEO) triblock copolymer, to introduce a layer of double bonds onto the surface. The Dacron(R) surface was then exposed to a solution of Pluronic(R) F108 (PF108), a commercially available PEO-poly(propylene oxide)-PEO (PEO-PPO-PEO) triblock copolymer. The surface with two adsorbed layers of PEO-PB-PEO and PF108 was gamma-irradiated in the presence of PF108 in the bulk solution for a total radiation dose of 0.8 Mrad. The bulk concentrations of PEO-PB-PEO and PF108 were varied to maximize the efficiency of PEO grafting. Fibrinogen adsorption on PEO-grafted surfaces was reduced more than 90%, compared with that on control surfaces, irrespective of the bulk concentrations of polymers used for grafting. Platelet adhesion was also reduced substantially by PEO grafting. Only a few round platelets were able to adhere to the PEO-grafted surface, while the control surface was fully covered with aggregates of activated platelets. PEO grafting on polyethylene terephthalate using PEO-PB-PEO and PEO-PPO-PEO block copolymers is a simple approach that can be used for various other biomaterials.

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