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Leach AR, Hann MM. The in silico world of virtual libraries. Drug Discov Today. 2000;5(8):326-336doi: 10.1016/s1359-6446(00)01516-6.
Leach, A. R., & Hann, M. M. (2000). The in silico world of virtual libraries. Drug discovery today, 5(8), 326-336. https://doi.org/10.1016/s1359-6446(00)01516-6
Leach, and Hann. "The in silico world of virtual libraries." Drug discovery today vol. 5,8 (2000): 326-336. doi: https://doi.org/10.1016/s1359-6446(00)01516-6
Leach AR, Hann MM. The in silico world of virtual libraries. Drug Discov Today. 2000 Aug;5(8):326-336. doi: 10.1016/s1359-6446(00)01516-6. PMID: 10893546.
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Drug Discov Today. 2000 Aug;5(8):326-336. doi: 10.1016/s1359-6446(00)01516-6.

The in silico world of virtual libraries.

Drug discovery today

Leach, Hann

Affiliations

  1. Computational Chemistry and Informatics Unit, Medicines Research Centre, GlaxoWellcome Research and Development, Gunnels Wood Road, Stevenage, Hertfordshire, UK SG1 2NY.

PMID: 10893546 DOI: 10.1016/s1359-6446(00)01516-6

Abstract

Combinatorial chemistry has provided medicinal chemists with an unprecedented ability to synthesize large numbers of molecules. However, early experience was that this did not result in any increase in the number of real candidates for lead optimization. Attention has increasingly focussed on the use of computational techniques for the design of combinatorial libraries. This review will describe some of the issues that have been considered in this area and discuss some of the possible developments in the near future.

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