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Szende B, Tyihák E, Szókán G, et al. Possible Role of Formaldehyde in the Apoptotic and Mitotic Effect of 1-Methyl-Ascorbigen. Pathol Oncol Res. 1995;1(1):38-42doi: 10.1007/BF02893582.
Szende, B., Tyihák, E., Szókán, G., & Kátay, G. (1995). Possible Role of Formaldehyde in the Apoptotic and Mitotic Effect of 1-Methyl-Ascorbigen. Pathology oncology research : POR, 1(1), 38-42. https://doi.org/10.1007/BF02893582
Szende, Béla, et al. "Possible Role of Formaldehyde in the Apoptotic and Mitotic Effect of 1-Methyl-Ascorbigen." Pathology oncology research : POR vol. 1,1 (1995): 38-42. doi: https://doi.org/10.1007/BF02893582
Szende B, Tyihák E, Szókán G, Kátay G. Possible Role of Formaldehyde in the Apoptotic and Mitotic Effect of 1-Methyl-Ascorbigen. Pathol Oncol Res. 1995;1(1):38-42. doi: 10.1007/BF02893582. PMID: 11173566.
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Pathol Oncol Res. 1995;1(1):38-42. doi: 10.1007/BF02893582.

Possible Role of Formaldehyde in the Apoptotic and Mitotic Effect of 1-Methyl-Ascorbigen.

Pathology oncology research : POR

Béla Szende, Ernô Tyihák, Gyula Szókán, György Kátay

Affiliations

  1. Semmelweis University of Medicine, 1st Institute of Pathology and Experimental Cancer Research, Budapest, Hungary.

PMID: 11173566 DOI: 10.1007/BF02893582

Abstract

PC-3 human prostate carcinoma cells were treated with 100 mg/ml 1-methyl-ascorbigen (Me-Asc). This treatment resulted in a significant decrease in tumor cell number in parallel with an increase in apoptotic cells. The formaldehyde (HCHO) level in the culture medium was also increased. Dimedone (Di), a known capture molecule forming formal-demethone with HCHO, applied simultaneously with Me-Asc in 10 mg/ml doses diminished the apoptosis-inducing effect of Me-Asc. The possible role of in situ generated HCHO in the induction of apoptosis is discussed.

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