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Kovalszky, Schaff Z, Lapis K, et al. Marker Enzymes of Rat Chemical Hepatocarcinogenesis in Human Liver Tumors. Pathol Oncol Res. 1996;2(1):56-58doi: 10.1007/BF02893950.
Kovalszky, Schaff, Z., Lapis, K., & Jeney, A. (1996). Marker Enzymes of Rat Chemical Hepatocarcinogenesis in Human Liver Tumors. Pathology oncology research : POR, 2(1), 56-58. https://doi.org/10.1007/BF02893950
Kovalszky, Ilona, et al. "Marker Enzymes of Rat Chemical Hepatocarcinogenesis in Human Liver Tumors." Pathology oncology research : POR vol. 2,1 (1996): 56-58. doi: https://doi.org/10.1007/BF02893950
Kovalszky, Schaff Z, Lapis K, Jeney A. Marker Enzymes of Rat Chemical Hepatocarcinogenesis in Human Liver Tumors. Pathol Oncol Res. 1996;2(1):56-58. doi: 10.1007/BF02893950. PMID: 11173585.
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Pathol Oncol Res. 1996;2(1):56-58. doi: 10.1007/BF02893950.

Marker Enzymes of Rat Chemical Hepatocarcinogenesis in Human Liver Tumors.

Pathology oncology research : POR

Ilona Kovalszky, Zsuzsa Schaff, Károly Lapis, András Jeney

Affiliations

  1. Semmelweis University of Medicine, 1st Institute of Pathology and Experimental Cancer Research, Budapest, Hungary.

PMID: 11173585 DOI: 10.1007/BF02893950

Abstract

Reduced glucose-6-phosphatase, increased GGT activity and reduction of cytochrome P-450 content are considered to be markers of chemical hepatocarcinogenesis in rats. The significance of these changes were studied in certain human liver lesions; adenoma, focal nodular hyperplasia and hepatocellular carcinoma all developed in non-cirrhotic livers. Enzymes showed normal values in 4 out of 5 adenomas, in 2/13 FNH and in 4/18 HCC samples. The decreased cP-450 content in HCC proved to be the most consistent alteration (12/18). Only 3 HCC samples possessed changes off all enzymes. These data suggest that at least those enzymes which are used as markers in rat chemical hepatocarcinogenesis have little or no biological significance in human liver tumors, primarily due to the intertumoral heterogeneity of enzyme activity. Such heterogeneity was observed in the peritumoral "normal" liver tissue, too.

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